A pharmacological analysis of processes underlying differential responding: a review and further experiments with scopolamine, amphetamine, lysergic acid diethylamide (LSD-25), chlordiazepoxide, physostigmine, and chlorpromazine

Frontali, Marina; Amorico, Luigi; Acetis, Luigi De; Bignami, Giorgio

doi:10.1016/s0091-6773(76)91764-8

Cited by 29 publications

(1 citation statement)

References 165 publications

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“…It is known that the administration of the anticholinesterase physostigmine (intraperitoneal or intracerebral) may influence learning in a variety of situations, including passive avoidance (PA). The effect depends on the dose: A significant reduction of acetylcholinesterase (AChE) activity through high doses impair learning, while a moderate reduction has no influence, and a small reduction may on the contrary facilitate acquisition, extinction, or retention processes (Banks & Russell, 1967;Bohdanecky & Jarvik, 1967;BureS, Bohdanecky, & Weiss, 1962;BureS, BureSova, Bohdanecky, & Weiss, 1964;Cox, 1974;Cox & Tye, 1973Frontali, Amorico, De Acetis, & Bignami, 1976;Glazer, 1972;Leaton & Kreindler, 1972;Micheau, Destrade, & Jaffard, 1985;Warburton & Brown, 1972;Weiner & Deutsch, 1968;Whitehouse, 1966).…”

Section: Introductionmentioning

confidence: 99%

Enhancement of passive avoidance learning through small doses of intra‐amygdaloid physostigmine in the young rat. Its relation to the development of acetylcholinesterase

Dumery

Derer

Blozovski

1988

Developmental Psychobiology

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Passive avoidance learning was studied in young rats 7-20 days old, in control conditions and after bilateral injections of physostigmine into the lateral amygdaloid nucleus. Acquisition in controls was possible from postnatal Day 8 on, progressed markedly after Day 11, and nearly reached maturity by Day 20. Physostigmine differentially altered acquisition depending on the dose: facilitation with low doses, no effect with moderate doses, and impairment with high doses. Enhanced learning through small doses of physostigmine was observed at all ages from Day 8 on, and was greater with 0.2 microgram than with 0.1 microgram. Maturation of the cholinergic innervation of the amygdaloid region was also studied between Days 9-20 using acetylcholine-esterase histochemistry. The results suggest that passive avoidance learning is dependent on amygdaloid cholinergic mechanisms early in life. In addition, very immature cholinergic systems, which are known to be uninfluenced by anticholinergic agents, react to anticholinesterases.

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