A Physiological Toxicokinetic Model for Exogenous and Endogenous Ethylene and Ethylene Oxide in Rat, Mouse, and Human: Formation of 2-Hydroxyethyl Adducts with Hemoglobin and DNA

Csanády, Gy.A.; Denk, B.; Pütz, Christian; Kreuzer, Paul E.; Kessler, Winfried; Baur, C.; Gargas, Michael L.; Filser, Johannes G.

doi:10.1006/taap.2000.8918

Cited by 58 publications

(52 citation statements)

References 85 publications

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“…Simulations did not agree well with data when published values for the blood:air partition coefficient (λ b:a ) were used, e.g. 0.15 (Steward et al, 1973) and 0.22 (Csanády et al, 2000) for λ b:a were used. Therefore, λ b:a was fitted to measurements with high initial concentration, resulting in λ b:a 0.092 ± 0.029.…”

Section: Pbpk Modelmentioning

confidence: 59%

“…Use of a previously published value for Cl (Csanády et al, 2000) gave good agreement between simulation and measurement.…”

Section: Pbpk Modelmentioning

confidence: 61%

“…Metabolic clearance (Cl), cardiac output (Q car ), lung volume and alveolar ventilation (A alv ) were assumed to scale linearly with body surface (Johanson and Filser, 1996), estimated from the volunteers height and weight (Mosteller, 1987). A mathematical description of the model and the physiological parameters used therein can be found elsewhere (Csanády et al, 2000).…”

Section: Discussionmentioning

confidence: 99%

“…The PBPK model used here is an adaptation of an earlier model (Csanády et al, 2000) that links the pharmacokinetics of ET and EO. Compartments related only to EO were omitted.…”

Section: Discussionmentioning

confidence: 99%

“…Knowledge of the pharmacokinetic parameters of ET in healthy human subjects is a prerequisite to useful applications in humans. Studies of the pharmacokinetics of ethylene in man have been published previously (Csanády et al, 2000). Often pharmacokinetic parameters are determined from gas uptake studies, which conventionally use a closed chamber technique (Filser, 1992) combined with gas chromatography.…”

Section: Introductionmentioning

confidence: 99%

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Pharmacokinetics of ethylene in man by on-line laser photoacoustic detection

Berkelmans

Moeskops

Bominaar

et al. 2003

Toxicology and Applied Pharmacology

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The pharmacokinetics of ethylene are determined using laser based photoacoustic detection and a closed chamber setup. Concentration-time data are analyzed using a two-compartment and a physiologically based pharmacokinetic (PBPK) model. Endogenous production was 92 ± 13 pmol· h −1 kg −1 for the two-compartment model and 75 ± 10 pmol·h −1 ·kg −1 for the PBPK model. These values agree with previous work at our department, but are significantly lower than published values based on gas chromatography. The blood:air partition coefficient in the PBPK model was determined by curve fitting, because simulations based on published values did not agree well with data. Curve fitting gave a value of 0.092 ± 0.029. The real-time nature and high sensitivity of photoacoustic detection make it a useful addition to gas chromatography in closed chamber studies.

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Section: Pbpk Modelmentioning

confidence: 59%

“…Use of a previously published value for Cl (Csanády et al, 2000) gave good agreement between simulation and measurement.…”

Section: Pbpk Modelmentioning

confidence: 61%

Section: Discussionmentioning

confidence: 99%

“…The PBPK model used here is an adaptation of an earlier model (Csanády et al, 2000) that links the pharmacokinetics of ET and EO. Compartments related only to EO were omitted.…”

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Pharmacokinetics of ethylene in man by on-line laser photoacoustic detection

Berkelmans

Moeskops

Bominaar

et al. 2003

Toxicology and Applied Pharmacology

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Aliphatic Hydrocarbons

Rushton,

Kocabas,

Barranco

2023

Patty's Toxicology

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The aliphatic hydrocarbons discussed in this chapter are open‐chain compounds that may be saturated or unsaturated. The saturated compounds, known as paraffin hydrocarbons or alkanes, include methane and its homologs having the empirical formula C n H 2 n +2 . The unsaturated compounds fall into a number of homologous series: ( 1 ) those containing one double bond (ethene and its homologs) and having the formula C n H 2n are known as olefins or alkenes; ( 2 ) those containing one triple bond (acetylene and its homologs) are called acetylenes or alkynes and have the formula C n H 2 n −2 ; ( 3 ) those having two double bonds (allene, 1,3‐butadiene, and 1,4‐pentadiene represent three types) are diolefins or alkadienes and also have the formula C n H 2 n −2 ; ( 4 ) those having a large number of double or triple bonds or both double and triple bonds are named in analogous fashion as alkatrienes , alkatetraenes , alkadiynes , alkenynes , and alkadienynes . Aliphatic hydrocarbons have the potential to act as asphyxiants and central nervous system (CNS) depressants. Serious toxic effects of aliphatic hydrocarbons include asphyxia and chemical pneumonitis for many of the compounds in this category. There is evidence in humans of axonal neuropathy for n ‐hexane and cancer for 1,3‐butadiene. The hepatic and renal systems can be impacted by target organ toxicity, some of which may not be relevant to human.

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Epoxy Compounds—Olefin Oxides (Ethylene Oxide, Propylene Oxide, and Miscellaneous Oxides)

Klapacz

Doskey

2023

Patty's Toxicology

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This chapter discusses the chemistry, uses, health information, and industrial hygiene handling procedures of epoxides, that is, substances containing strained, three‐membered rings with two adjacent carbons and one oxygen atom. This functionality underlies epoxides' high reactivity, physicochemical properties, and toxicity. The majority of the content is dedicated to ethylene oxide and propylene oxide, but other epoxides are also of industrial interest and are described here; their databases have evolved over the last couple of decades and this new understanding is highlighted here. These are 1,2‐butylene oxide, 2,3‐epoxybutane, butadiene diepoxide, vinylcyclohexene monoxide, vinylcyclohexene dioxide, and styrene oxide.

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A Physiological Toxicokinetic Model for Exogenous and Endogenous Ethylene and Ethylene Oxide in Rat, Mouse, and Human: Formation of 2-Hydroxyethyl Adducts with Hemoglobin and DNA

Cited by 58 publications

References 85 publications

Pharmacokinetics of ethylene in man by on-line laser photoacoustic detection

Pharmacokinetics of ethylene in man by on-line laser photoacoustic detection

Aliphatic Hydrocarbons

Epoxy Compounds—Olefin Oxides (Ethylene Oxide, Propylene Oxide, and Miscellaneous Oxides)

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