A pilot study for determination of anxiety related SLC6A4 promoter "S" and "L" alleles in healthy Turkish athletes

Çorak, Ahmet; Kapıcı, Sezgin; Sercan, Canan; Akkoç, Orkun; Ulucan, Korkut

doi:10.14715/cmb/2017.63.5.6

Cited by 17 publications

(8 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Also there is evidence that high lactate levels are associated with muscle hypertrophy, which in turn is associated with anaerobic metabolism (Bonen et al, 1998). Environmental factors, like training, nutrition have crucial effects on athletic performance (Corak et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

HETEROZYGOUS GENOTYPE OF MONOCARBOXYL TRANSFERASE 1 (rs1049434) POLYMORPHISM COMMONS IN A TURKISH ATHLETE COHORT

Zelka¹,

Kasikci²,

Doğan³

et al. 2019

JNBS

View full text Add to dashboard Cite

There are many parameters that have effects the success of athletes, like exercise, motivation, determination, nutrition, all of which have genetic backgrounds. To have the optimal approach, all of these conditions should complement each other. In this study, we aimed to analyze and compare the monocarboxyl transferase 1 (mCT1) rs1049434 polymorphism, which is important to determine the lactate levels, in long and short distance running athletes. A total of 30 athletes, 15 of which were power athletes and 15 were endurance, were enrolled for the study. DNA isolations were carried out by using commercially available DNA isolation Kit, and genotyping process was by real-time PCR. Of the 15 power athletes, 14 (93%) and 1 (7%) athletes had AT and TT genotypes, respectively. We detected no AA genotype in power athletes. In endurance cohort, 4 (27%), 8 (53%) and 3 (20%) athletes had AA, AT and TT genotypes, respectively. When we count the alleles, A allele was counted as 14 (47%) and 16 (53%) in power and endurance athletes. For T allele, 16 (53%) and 14 (47%) were counted in power and endurance cohorts. No statistically significant difference was found between groups in the terms of genotype and allele. In our cohort, AT genotype was higher in both groups, whereas both alleles were equal in our cohort. Our basic goal is to be able to channel the athlete correctly and carry it to maximum success in a shorter period of time considering the genetic predisposition.

show abstract

Section: Discussionmentioning

confidence: 99%

HETEROZYGOUS GENOTYPE OF MONOCARBOXYL TRANSFERASE 1 (rs1049434) POLYMORPHISM COMMONS IN A TURKISH ATHLETE COHORT

Zelka¹,

Kasikci²,

Doğan³

et al. 2019

JNBS

View full text Add to dashboard Cite

show abstract

“…Relevant studies in the literature have detected that the basic motoric properties such as speed, strength, flexibility and nerve muscle coordination that determine the ability of an individual are related to genetic factors (Kaynar and Bilici, 2017). Furthermore, an individual's athletic ability is determined by the interaction between athletic ability, differences of the unique genetic structure and the environmental factors such as physiological adaptation to training, food habits, and sleeping pattern (Ulucan et al, 2015).Even more, nearly 70% of the athletic performance variance is explained with genetic factors (Corak et al, 2017). Peroxisome proliferator activated receptor alpha (PPAR-a) polymorphism ( rs4253778) is also one of the genes that affect athletic performance (Rankinen et al, 2009).…”

Section: Introductionmentioning

confidence: 99%

Eli̇t Kayakli Koşucularda Ppar-A'nin (Rs4253778) Serum Li̇pi̇tleri̇ Üzeri̇ndeki̇ Etki̇si̇ni̇n İncelenmesi̇

Kaynar

Bilici

Sercan

et al. 2021

Spor Ve Performans Araştırmaları Dergisi

View full text Add to dashboard Cite

The purpose of this study was to examine the effects of PPAR-a (rs4253778) on serum lipids in elite crosscountry skiers. This study included 34 cross-country skiers (23 males and 11 females who participated in the Turkish skiing national team camp). Genotyping for the PPAR-a gene rs4253778 G/C polymorphism was performed by PCR on Tercyk multicanal amplificator and restriction enzyme digestion. Statistical analysis was done by using the SPSS 22.0 package program. Genotypic frequency of the PPAR-a polymorphism was detected in cross-country skiers. PPAR-a GG, GC and CC genotypes were detected as 67.64%, 23.52% and 8.82%, respectively in 34 cross-country skiers while PPAR-a GG, GC and CC genotypes were detected as 47.05%, 16.64%, and 2.94%, respectively in elite males. PPAR-a GG, GC and CC genotypes were detected as 20.58 %, 5.88%, and 5.88%, respectively in females. PPAR-a G and C allele were detected as 49 and 19, respectively in 34 elite endurance athletes. In the present study, the GG genotypes were detected at higher frequencies in elite athletes (67.64% respectively) than GC and CC (23.52% and 8.82%, respectively). The difference between the PPAR-a G/C gene polymorphism of Turkish elite cross-country skiers and serum total cholesterol, HDLcholesterol, LDL-cholesterol and TG levels was not statistically significant. Although there was not any statistically significant difference between the PPAR-a G/C gene polymorphism and lipid profiles of Turkish elite cross-country skiers, it is foreseen that PPAR-α genes have an important effect on endurance performance in sports requiring endurance such as cross-country skiing.

show abstract

“…Athletic performance is a combination of innate genetic factors as well as several environmental factors, including nutrition, psychological factors and extent of training ( 1 ). The current body of research on athletic performance places a heavy focuses on genetic variants that contribute notably to the improved performance of individuals, as well as means of increasing performance ( 2 , 3 ).…”

Section: Introductionmentioning

confidence: 99%

Distribution of α‑actinin‑3 rs1815739 and angiotensin‑1 converting enzyme InDel polymorphisms in Turkish bodybuilders

Polat

Doğan

et al. 2020

Biomed Rep

View full text Add to dashboard Cite

The determination of the genetic profiles of successful athletes and the effects of these genetic parameters on athletic performance is gaining increasing interest. The majority of studies assessing the genetics of athletes usually analyse the most well-known genetic variations in athletes associated with the different specialties. The aim of the present study was to analyse the ACE InDel and ACTN3 rs1815739 polymorphisms in Turkish bodybuilders. A total of 11 male bodybuilders were recruited and genotyped for these polymorphisms. The respective percentage of the ACE II, ID and DD genotypes were 18, 73 and 9. For the ACTN3 genotype, the respective frequencies were 55 and 45 for the RX and RR genotypes. No XX genotype was detected. The allelic counts were 12 (55%) for I and 10 (45%) for the D alleles of ACE ; and 12 (55%) and 10 (45%) for R and X alleles, respectively, for the ACTN3 genotype. Additionally, 5 athletes had ID + RX genotypes in terms of ACE InDel and ACTN3 rs1815739 polymorphisms, respectively. These results indicate the importance of endurance related alleles of ACE and ACTN3 in bodybuilders. The results of the present are in agreement with previous studies, highlighting a potential association between specific polymorphisms and the endurance-related nature of bodybuilders. Further studies with larger cohorts are required to understand the association between these polymorphisms and specific parameters performance in bodybuilders.

show abstract

A pilot study for determination of anxiety related SLC6A4 promoter "S" and "L" alleles in healthy Turkish athletes

Cited by 17 publications

References 21 publications

HETEROZYGOUS GENOTYPE OF MONOCARBOXYL TRANSFERASE 1 (rs1049434) POLYMORPHISM COMMONS IN A TURKISH ATHLETE COHORT

HETEROZYGOUS GENOTYPE OF MONOCARBOXYL TRANSFERASE 1 (rs1049434) POLYMORPHISM COMMONS IN A TURKISH ATHLETE COHORT

Eli̇t Kayakli Koşucularda Ppar-A'nin (Rs4253778) Serum Li̇pi̇tleri̇ Üzeri̇ndeki̇ Etki̇si̇ni̇n İncelenmesi̇

Distribution of α‑actinin‑3 rs1815739 and angiotensin‑1 converting enzyme InDel polymorphisms in Turkish bodybuilders

Contact Info

Product

Resources

About

A pilot study for determination of anxiety related SLC6A4 promoter "S" and "L" alleles in healthy Turkish athletes

Cited by 17 publications

References 21 publications

HETEROZYGOUS GENOTYPE OF MONOCARBOXYL TRANSFERASE 1 (rs1049434) POLYMORPHISM COMMONS IN A TURKISH ATHLETE COHORT

HETEROZYGOUS GENOTYPE OF MONOCARBOXYL TRANSFERASE 1 (rs1049434) POLYMORPHISM COMMONS IN A TURKISH ATHLETE COHORT

Eli̇t Kayakli Koşucularda Ppar-A'nin (Rs4253778) Serum Li̇pi̇tleri̇ Üzeri̇ndeki̇ Etki̇si̇ni̇n İncelenmesi̇

Distribution of &alpha;‑actinin‑3 rs1815739 and angiotensin‑1 converting enzyme InDel polymorphisms in Turkish bodybuilders

Contact Info

Product

Resources

About

Distribution of α‑actinin‑3 rs1815739 and angiotensin‑1 converting enzyme InDel polymorphisms in Turkish bodybuilders