A plasmon-enhanced theranostic nanoplatform for synergistic chemo-phototherapy of hypoxic tumors in the NIR-II window

Chen, Mingming; Hao, Hai-Li; Zhao, Wei; Zhao, Xia; Chen, Hong‐Yuan; Xu, Jing‐Juan

doi:10.1039/d1sc01760h

Cited by 47 publications

(33 citation statements)

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“…The metal nanoparticles efficiently convert light energy into highly localized heat energy (photothermal therapy) via a phenomenon known as localized surface plasmon resonance (LSPR) to destroy cancer cells and minimize collateral damage to adjacent normal tissues ( He et al, 2021a ; Cai et al, 2021 ; Shan et al, 2021 ; Shanmugam et al, 2021 ; Zhu et al, 2022 ). Plasmonic gold NTA-mediated photothermal therapy has also been tested in combination with chemotherapy and immunotherapy to achieve synergistic tumor inhibition in the 4T1 tumor model ( Zhang et al, 2020 ; Chen et al, 2021 ). On the other hand, plasmonic NTA also possesses the ability to utilize light energy to generate reactive oxygen species (photodynamic therapy) for the destruction of tumors ( He et al, 2021b ; Chen et al, 2021 ; Shanmugam et al, 2021 ).…”

Section: Discussionmentioning

confidence: 99%

“…Plasmonic gold NTA-mediated photothermal therapy has also been tested in combination with chemotherapy and immunotherapy to achieve synergistic tumor inhibition in the 4T1 tumor model ( Zhang et al, 2020 ; Chen et al, 2021 ). On the other hand, plasmonic NTA also possesses the ability to utilize light energy to generate reactive oxygen species (photodynamic therapy) for the destruction of tumors ( He et al, 2021b ; Chen et al, 2021 ; Shanmugam et al, 2021 ). In addition, plasmonic NTA enables real-time visualization of the tumor and precise tracking of NTA in the tumors via photoacoustic imaging to facilitate image-guided treatment ( He et al, 2021a ; Shan et al, 2021 ; Shanmugam et al, 2021 ; Zhu et al, 2022 ).…”

Section: Discussionmentioning

confidence: 99%

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Emerging Nanotheranostics for 5-Fluorouracil in Cancer Therapy: A Systematic Review on Efficacy, Safety, and Diagnostic Capability

et al. 2022

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The conventional concept of using nanocarriers to deliver chemotherapeutic drugs has advanced to accommodate additional diagnostic capability. Nanotheranostic agents (NTA), combining both treatment and diagnostic tools, are an ideal example of engineering-health integration for cancer management. Owing to the diverse materials used to construct NTAs, their safety, effectiveness, and diagnostic accuracy could vary substantially. This systematic review consolidated current NTAs incorporating 5-fluorouracil and elucidated their toxicity, anticancer efficacy, and imaging capability. Medline and Embase databases were searched up to March 18, 2022. The search, selection, and extraction were performed by the preferred reporting items for systematic reviews and meta-analysis (PRISMA) guidelines to ensure completeness and reproducibility. Original research papers involving 5-fluorouracil in the preparation of nanoparticles which reported their efficacy, toxicity, and diagnostic capability in animal cancer models were recruited. The quality of included studies was assessed using the Collaborative Approach to Meta-Analysis and Review of Animal Data from Experimental Studies (CAMARADES) checklist. Nine studies were eligible for the systematic review. There was no significant toxicity reported based on animal weight and organ histology. Complete tumor remission was observed in several animal models using chemo-thermal ablation with NTAs, proving the enhancement of 5-fluorouracil efficacy. In terms of imaging performance, the time to achieve maximum tumor image intensity correlates with the presence of targeting ligand on NTAs. The NTAs, which are composed of tumor-targeting ligands, hold promises for further development. Based on the input of current NTA research on cancer, this review proposed a checklist of parameters to recommend researchers for their future NTA testing, especially in animal cancer studies.Systematic Review Registration: website, identifier registration number.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Emerging Nanotheranostics for 5-Fluorouracil in Cancer Therapy: A Systematic Review on Efficacy, Safety, and Diagnostic Capability

et al. 2022

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“…Despite the significant achievements in chemotherapy, it is still facing apparent and nonnegligible challenges, such as non-specific distribution, rapid metabolic clearance of drugs as well as the possible development of multidrug resistance (MDR) [2,3]. Nowadays, new therapeutic methods such as photodynamic therapy (PDT), photothermal therapy (PTT), immunotherapy, gene therapy and chemodynamic therapy (CDT) have drawn great attention, with success to a certain extent [4,5]. However, the therapeutic outcomes of monotherapy alone are generally unsatisfactory because of the complexity, diversity, metastasis, recurrence and resistance of cancers [2,6,7].…”

Section: Introductionmentioning

confidence: 99%

“…Among various multimodal therapies, chemo-phototherapy has been extensively investigated [8][9][10][11][12]. Phototherapy, mainly including PDT and PTT, is expected to possess many exclusive advantages, such as a noninvasive nature, high spatiotemporal controllability, diminutive side effects and negligible drug resistance [5,13,14]. On the other hand, PDT and PTT also face some bottleneck problems, including tumor hypoxia, insufficient light penetration depth and the heat resistance of the tumor cells [15].…”

Section: Introductionmentioning

confidence: 99%

NIR and Reduction Dual-Sensitive Polymeric Prodrug Nanoparticles for Bioimaging and Combined Chemo-Phototherapy

Xue

et al. 2022

Polymers

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The combination of chemotherapy, photothermal therapy (PTT) and photodynamic therapy (PDT) based on a single nanosystem is highly desirable for cancer treatment. In this study, we developed a versatile Pt(IV) prodrug-based nanodrug, PVPt@Cy NPs, to realize synchronous chemotherapy, PDT and PTT and integrate cancer treatment with bioimaging. To construct PVPt@Cy NPs, the amphiphilic Pt(IV)-based polymeric prodrug PVPt was synthesized by a facile one-pot coupling reaction, and then it was used to encapsulate an optotheranostic agent (HOCyOH, Cy) via hydrophobic interaction-induced self-assembly. These NPs would disaggregate under acidic, reductive conditions and NIR irradiation, which are accompanied by photothermal conversion and reactive oxygen species (ROS) generation. Moreover, the PVPt@Cy NPs exhibited an enhanced in vitro anticancer efficiency with 808-nm light irradiation. Furthermore, the PVPt@Cy NPs showed strong NIR fluorescence and photothermal imaging in H22 tumor-bearing mice, allowing the detection of the tumor site and monitoring of the drug biodistribution. Therefore, PVPt@Cy NPs displayed an enormous potential in combined chemo-phototherapy.

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“…11,12 According to the Arrhenius formula, temperature can increase the activity of enzymes. [13][14][15] As the temperature rises, the enzyme activity increases. Therefore, the construction of light-enhancing nanozymes has broad application prospects.In recent years, photothermal therapy has been used as a new type of non-invasive treatment, which uses lasers to irradiate nanomaterials to heat up and then kill bacteria.…”

Section: Introductionmentioning

confidence: 99%

“One body and two wings” novel nanozyme combined with photothermal therapy for Combat Drug-Resistant Bacteria

Huang

Wang

et al. 2022

J Biomater Appl

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Bacterial resistance caused by antibiotic therapy is a serious problem. Therefore, there is an urgent need to find alternative methods to overcome bacterial resistance. Herein, we synthesized a new type of iridium oxide (IrOx) as an alternative to antibiotics. Iridium oxide not only has good catalytic properties, but also has photothermal properties, and then realizes the “one body and two wings” strategy to enhance the antibacterial effect. Research results show that near-infrared light can enhance the peroxidase catalytic activity of IrOx and generate highly toxic hydroxyl radicals (·OH) by catalyzing hydrogen peroxide (H2O2). Hydroxyl radicals have a high redox potential, which can overcome the drug resistance of gram-positive and negative bacteria. Importantly, IrOx has no obvious cellular and in vivo toxicity. Accordingly, the novel photothermal nanozyme is expected to be applied to bacterial infectious diseases, such as wound healing, sepsis, and implant-related infections.

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A plasmon-enhanced theranostic nanoplatform for synergistic chemo-phototherapy of hypoxic tumors in the NIR-II window

Abstract: Development of simple and effective synergistic therapy by combination of different therapeutic modalities within one single nanostructure is of great importance for cancer treatment. In this study, by integrating the...

Cited by 47 publications

References 63 publications

Emerging Nanotheranostics for 5-Fluorouracil in Cancer Therapy: A Systematic Review on Efficacy, Safety, and Diagnostic Capability

Emerging Nanotheranostics for 5-Fluorouracil in Cancer Therapy: A Systematic Review on Efficacy, Safety, and Diagnostic Capability

NIR and Reduction Dual-Sensitive Polymeric Prodrug Nanoparticles for Bioimaging and Combined Chemo-Phototherapy

“One body and two wings” novel nanozyme combined with photothermal therapy for Combat Drug-Resistant Bacteria

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