A polymeric high-throughput pressure-driven micromixer using a nanoporous membrane

Jännig, Oliver; Nguyen, Nam‐Trung

doi:10.1007/s10404-010-0685-1

Cited by 37 publications

(21 citation statements)

References 18 publications

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“…The equations were formulated with reference to previously published articles 42,43 . The histogram matrix was retrieved using the ImageJ software, with the pixel intensity weight for the particular color intensity.…”

Section: Experimental Methodsmentioning

confidence: 99%

A “twisted” microfluidic mixer suitable for a wide range of flow rate applications

et al. 2016

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This paper proposes a new “twisted” 3D microfluidic mixer fabricated by a laser writing/microfabrication technique. Effective and efficient mixing using the twisted micromixers can be obtained by combining two general chaotic mixing mechanisms: splitting/recombining and chaotic advection. The lamination of mixer units provides the splitting and recombination mechanism when the quadrant of circles is arranged in a two-layered serial arrangement of mixing units. The overall 3D path of the microchannel introduces the advection. An experimental investigation using chemical solutions revealed that these novel 3D passive microfluidic mixers were stable and could be operated at a wide range of flow rates. This micromixer finds application in the manipulation of tiny volumes of liquids that are crucial in diagnostics. The mixing performance was evaluated by dye visualization, and using a pH test that determined the chemical reaction of the solutions. A comparison of the tornado-mixer with this twisted micromixer was made to evaluate the efficiency of mixing. The efficiency of mixing was calculated within the channel by acquiring intensities using ImageJ software. Results suggested that efficient mixing can be obtained when more than 3 units were consecutively placed. The geometry of the device, which has a length of 30 mm, enables the device to be integrated with micro total analysis systems and other lab-on-chip devices.

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Section: Experimental Methodsmentioning

confidence: 99%

A “twisted” microfluidic mixer suitable for a wide range of flow rate applications

et al. 2016

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“…262, 267 Voltage-induced vortices above a Nafion membrane fabricated in PMMA were found to enhance mixing. 268 Micromixers based on electrokinetic instability utilize a fluctuating electric field. A combined approach with a microfluidic T-junction with patterned regions and pulsed EOF showed increased mixing efficiency of rhodamine B.…”

Section: Functions In Lab-on-a-chip Systemsmentioning

confidence: 99%

Advances in Microfluidic Materials, Functions, Integration, and Applications

2013

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“…[2][3][4][5][6][7][8][9][10]. These devices offer significant advantages over their traditional counterparts, including reduced reagent and sample consumption, improved sensitivity, faster response time, lower power consumption, greater portability, lower fabrication and operating costs.…”

Section: Introductionmentioning

confidence: 97%

Numerical analysis of a rapid magnetic microfluidic mixer

et al. 2011

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This paper presents a detailed numerical investigation of the novel active microfluidic mixer proposed by Wen et al. (Electrophoresis 2009, 30, 4179-4186). This mixer uses an electromagnet driven by DC or AC power to induce transient interactive flows between a water-based ferrofluid and DI water. Experimental results clearly demonstrate the mixing mechanism. In the presence of the electromagnet's magnetic field, the magnetic nanoparticles create a body force vector that acts on the mixed fluid. Numerical simulations show that this magnetic body force causes the ferrofluid to expand significantly and uniformly toward miscible water. The magnetic force also produces many extremely fine finger structures along the direction of local magnetic field lines at the interface in both upstream and downstream regions of the microchannel when the external steady magnetic strength (DC power actuation) exceeds 30 Oe (critical magnetic Peclet number Pe(m),cr = 2870). This study is the first to analyze these pronounced finger patterns numerically, and the results are in good agreement with the experimental visualization of Wen et al. (Electrophoresis 2009, 30, 4179-4186). The large interfacial area that accompanies these fine finger structures and the dominant diffusion effects occurring around the circumferential regions of fingers significantly enhance the mixing performance. The mixing ratio can be as high as 95% within 2.0 s. at a distance of 3.0 mm from the mixing channel inlet when the applied peak magnetic field supplied by the DC power source exceeds 60 Oe. This study also presents a sample implementation of AC power actuation in a numerical simulation, an experimental benchmark, and a simulation of DC power actuation with the same peak magnetic strength. The simulated flow structures of the AC power actuation agree well with the experimental visualization, and are similar to those produced by DC power. The AC and DC power actuated flow fields exhibited no significant differences. This numerical study suggests approaches to maximize the performance of the proposed rapid magnetic microfluidic mixer, and confirms its exciting potential for use in lab-on-a-chip systems.

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A polymeric high-throughput pressure-driven micromixer using a nanoporous membrane

Cited by 37 publications

References 18 publications

A “twisted” microfluidic mixer suitable for a wide range of flow rate applications

A “twisted” microfluidic mixer suitable for a wide range of flow rate applications

Advances in Microfluidic Materials, Functions, Integration, and Applications

Numerical analysis of a rapid magnetic microfluidic mixer

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