A population based study of Helicobacter pylori infection in a European country: the San Marino Study. Relations with gastrointestinal diseases.

Gasbarrini, Giovanni; Pretolani, S.; Bonvicini, F.; Gatto, Maria Rosaria; Tonelli, E.; Mégraud, Françis; Mayo, Kathryn; Ghironzi, Giancarlo; Giulianelli, G.; Grassi, Mario

doi:10.1136/gut.36.6.838

Cited by 91 publications

(61 citation statements)

References 33 publications

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“…Our result showed that the prevalence of anti-H pylori antibody was significantly higher in males compared to females. Although, similar results reported from other countries [34,35] . Our results were inconsistent with other finding recently, reported in Iranian children from Tehran city, so that higher prevalence of H pylori were found in females compared to males [8] .…”

Section: Discussionsupporting

confidence: 79%

Specific serum immunoglobulin G to H pylori and CagA in healthy children and adults (south-east of Iran)

Jafarzadeh¹,

Rezayati²,

Nemati³

2007

WJG

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AIM:To evaluate the serologic IgG response to H pylori and CagA across age groups and in healthy children and adults. METHODS:Totally, 386 children aged 1-15 years and 200 adults aged 20-60 years, were enrolled to study. The serum samples of participant were tested for presence of anti-H pylori and anti-CagA IgG by using ELISA method. RESULTS:The seroprevalence of H pylori in adults was significantly higher than that observed in children (67.5% vs 46.6%; P < 0.000003). In children, the seropositivity rate in males (51.9%) was significantly (P < 0.05) higher than that observed in females (41.7%). The prevalence of serum anti-CagA antibody was 72.8% and 67.4% in infected children and adults, respectively. The mean titer of serum anti-CagA antibodies was significantly higher among children in comparison to adults (64.1 Uarb/mL vs 30.7; P < 0.03). In infected children and adults the prevalence of serum anti-CagA antibody was higher in males compared to females (78.4% vs 66.3%; P = 0.07 and 75.6% vs 54.71%; P < 0.04, respectively). The age-specific prevalence of anti-H pylori and anti-CagA antibody (in infected subjects) was 37.6% and 59.57% at age 1-5 years, 46.9% and 75% at age 6-10 years, 54.9% and 79.45% at age 11-15, 59.01% and 83.33% at age 20-30 years, 66.6% and 60.52% at age 31-40 years, 73.46% and 63.88% at age 41-50 years and 75.75% and 60% at age 51-60 years with mean titer of anti-CagA antibody of 75.94, 63.32, 57.11, 52.06, 23.62, 21.52 and 21.80 Uarb/mL, respectively. There was significant difference between mean serum anti-CagA antibody in age subgroups (P < 0.001). CONCLUSION:These results showed that anti-H pylori and anti-CagA antibodies were common in the children and adults. The H pylori -specific antibodies influenced by age and sex of subjects. Moreover, it seems that males are more susceptible to infection with CagA + strains compared to females. The seroprevalence of anti-CagA antibody was increased with age, up to 30 years and then decreased. It was also found that the magnitude of the IgG response to CagA decreased with advanced age.

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Section: Discussionsupporting

confidence: 79%

Specific serum immunoglobulin G to H pylori and CagA in healthy children and adults (south-east of Iran)

Jafarzadeh¹,

Rezayati²,

Nemati³

2007

WJG

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“…In our study we found no difference in H. pylori prevalence between the sexes. Regarding the influence of the lifestyle on the prevalence of H. pylori infection our data supports the hypothesis that there is no significant association between H. pylori and alcohol use or smoking which was shown in multiple studies [20][21][22][23]. Markers of low socioeconomic status such as a low family income [24] and low educational level [25][26][27][28], had all a higher likelihood of carrying H. pylori infection.…”

Section: Discussionsupporting

confidence: 75%

“…However in our study, 31.6% of GU patients and 62.5% of DU patients were H. pylori positive. This decrease in the prevalence of PUD related to H. pylori was reported in several studies in Australia and the United States of America [20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35][36][37]. Several factors may have influenced the decreased rate of PUD associated with H. pylori such as the use NSAIDs.…”

Section: Discussionmentioning

confidence: 99%

Epidemiology of Helicobacter pylori Infection among Symptomatic Patients, Correlation with Endoscopic Findings and it’s Association with Type II Diabetes Mellitus

Abboud¹,

Khalek²

2017

J Gastrointest Dig Syst

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“…There are duodenal ulcer clusters in Scotland, Africa, Ethiopia, southern India, southern China, and eastern Australia. [2][3][4] Japan has a high incidence of gastric cancer, 5 with other clusters in northern China, 6 northern Italy, 7 southern Mexico, 8 and the Andean region. 9 Cancer is the first cause of mortality in the Venezuelan Andean states.…”

mentioning

confidence: 99%

Short report: socioeconomic and seasonal variations of Helicobacter pylori infection in patients in Venezuela.

Domínguez-Bello¹,

Beker²,

Guelrud³

et al. 2002

The American Journal of Tropical Medicine and Hygiene

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Abstract. Infection by Helicobacter pylori is recognized as a risk factor for gastric cancer and peptic ulcer disease. Venezuela has regions with different gastric cancer risks; the Andean region has the highest gastric cancer mortality in the country. We performed a cross-sectional study on 357 patients who underwent endoscopy attending 2 private (n ϭ 76) and one public hospital in Caracas, Venezuela (n ϭ 215), and one public hospital in the Andes (n ϭ 66) to determine H. pylori infection (by a rapid biopsy urease test and histology). The proportion of infected patients in Caracas was significantly higher in public hospitals (72%) than in private hospitals (46%; P ϭ 0.00001), and there was no significant variation the Andes and Caracas (P ϭ 0.7001). When analyzing the data from the public hospital in Caracas, we found that the frequency of infected patients was significantly higher during the rain (96%) than during the dry months (70%, P ϭ 0.00000001). Differences in prevalence of infection in symptomatic patients was not related to the risk of gastric cancer but to socioeconomic differences. Rain-dependent factors that may be exacerbating the clinical activity of nonulcer dyspepsia in people infected with H. pylori deserve further study.Although most infected people remain asymptomatic, infection by Helicobacter pylori is recognized as a risk factor for gastric cancer, chronic gastritis, and peptic ulcer disease. 1 The outcome of peptic ulceration or gastric adenocarcinoma shows geographical variations. There are duodenal ulcer clusters in Scotland, Africa, Ethiopia, southern India, southern China, and eastern Australia. 2-4 Japan has a high incidence of gastric cancer, 5 with other clusters in northern China, 6 northern Italy, 7 southern Mexico, 8 and the Andean region. 9 Cancer is the first cause of mortality in the Venezuelan Andean states. As many as 4.1% of registered deaths were caused by gastric malignant tumors, compared with 1.4% in the Central states. 10 Because H. pylori infection plays a role in the etiology of gastric cancer, we hypothesized that prevalence of H. pylori in symptomatic patients in the Andes may be higher than in Caracas, Venezuela.We studied 357 patients who were referred to endoscopy who attended one public hospital in the Andean city of San Cristóbal (66 patients) and 3 hospitals in Caracas. Caracas hospitals comprised a single public hospital (215 patients) and 2 private hospitals (76 patients). Patients (or the legal representative) voluntarily signed a consent of participation. Patients referred to endoscopy who had not received antibiotics, anti-inflammatory steroids, H2 antihistaminics, or proton pump inhibitors in 30 days before endoscopy, were enrolled in the study. Helicobacter pylori infection was determined in 2 antrum gastric specimens from each patient. One was introduced in a rapid urease test 11 and the other was fixed in formaldehyde for the histology study after staining with hematoxylin and eosin. Patients were considered infected if one or both tests were positi...

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A population based study of Helicobacter pylori infection in a European country: the San Marino Study. Relations with gastrointestinal diseases.

Cited by 91 publications

References 33 publications

Specific serum immunoglobulin G to H pylori and CagA in healthy children and adults (south-east of Iran)

Specific serum immunoglobulin G to H pylori and CagA in healthy children and adults (south-east of Iran)

Epidemiology of Helicobacter pylori Infection among Symptomatic Patients, Correlation with Endoscopic Findings and it’s Association with Type II Diabetes Mellitus

Short report: socioeconomic and seasonal variations of Helicobacter pylori infection in patients in Venezuela.

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