A population‐based study of craniosynostosis in metropolitan Atlanta, 1989–2003

Abstract

Craniosynostosis is a birth defect characterized by premature fusion of one or more cranial sutures. We describe the birth prevalence of craniosynostosis and related risk factors among infants born to residents of metropolitan Atlanta during 1989-2003. Data from the Metropolitan Atlanta Congenital Defects Program (MACDP) were used to identify infants with craniosynostosis. Case records with a code for craniosynostosis were reviewed to substantiate the diagnosis of craniosynostosis and to classify infants as having isolated craniosynostosis (no other unrelated major defects), multiple defects (one or more additional major, unrelated defects), or a syndrome (recognized or strongly suspected single-gene condition or chromosome abnormality). Vital records data on births of Georgia residents were used to analyze craniosynostosis prevalence by year of birth, maternal race and age, parity, plurality, and infants' sex, birth weight, and gestational age. We identified 281 infants born with craniosynostosis in metropolitan Atlanta during 1989-2003: 84% with isolated craniosynostosis, 7% with multiple defects, and 9% with syndromes. The birth prevalence was 4.3 per 10,000 births, results consistent with findings from other population-based studies using similar case definitions. Apert syndrome was diagnosed in 40% of the syndromic cases, and sagittal synostosis was diagnosed in 39% of the cases of nonsyndromic craniosynostosis. Maternal age 35 years or older, multiple birth, male sex, and birth weight >4,000 g were risk factors for craniosynostosis.

p38 Inhibition ameliorates skin and skull abnormalities in Fgfr2 Beare-Stevenson mice

“…It can also be associated with midfacial hypoplasia as well as increased intracranial pressure. Craniosynostosis occurs in 1 in 2,500 newborns across all ethnicities and is present in more than 100 human skeletal syndromes (10)(11)(12)(13). The FGF receptor (FGFR) mutations that underlie the genetic basis of BSS are FGFR2 Y375C and S372C (human FGFR2 IIIc protein NP_000132.3) of the juxtamembrane domain (4,(14)(15)(16)(17)(18)(19).…”

Cranial Ultrasound as a First-Line Imaging Examination for Craniosynostosis

“…[1][2][3] Craniosynostosis can present as an isolated finding or in association with various syndromes. Although an isolated single cranial suture closure usually causes only cosmetic deformity, 1 poor gross motor function and learning difficulties resulting from even a single suture synostosis have been reported.…”

“…[1][2][3] Craniosynostosis can present as an isolated finding or in association with various syndromes. Although an isolated single cranial suture closure usually causes only cosmetic deformity, 1 poor gross motor function and learning difficulties resulting from even a single suture synostosis have been reported. [4][5][6][7] Multiple suture synostosis, usually syndromic, has been associated with several complications, such as increased intracranial pressure, headaches, and delayed neurodevelopment.…”

Anteriorna plagiocefalija – Prikaz primera in opis kirurške tehnike

“…Dvakrat pogosteje zbolevajo deklice. Enostranska kraniosinostoza koronarnega šiva je petkrat bolj pogosta od obojestranske, večkrat pa je prizadeta desna stran (2,3).…”

“…Pri zelo hudih oblikah anteriorne plagiocefalije lahko deformacija zajame tudi posterione segmente lobanje, kraniocervikalni prehod in celo prvo vratno vretence (2)(3)(4).…”