A porous reduced graphene oxide/chitosan-based nanocarrier as a delivery system of doxorubicin

Abstract

Nowadays, the concept of drug transmission is an important topic in the field of drug delivery research.

Polymer grafted magnetic graphene oxide as a potential nanocarrier for pH-responsive delivery of sparingly soluble quercetin against breast cancer cells

“…The electrodes were prepared by drop-casting method as reported previously. 35 Briefly, 1 mg of QSR, GO–PVP–Fe 3 O 4 and GO–PVP–Fe 3 O 4 –QSR were dispersed in 1 mL of DD water separately and sonicate for 1 hour to make a homogenous mixture. For the preparation of electrode, initially glassy carbon electrode (GCE) was polished with the alumina power, then 60 μL of each QSR, GO–PVP–Fe 3 O 4 and GO–PVP–Fe 3 O 4 –QSR were drop cast separately onto the surface of GCE and dried at 60 °C in the oven.…”

Green decoration of graphene oxide Nano sheets with gelatin and gum Arabic for targeted delivery of doxorubicin

“…However, due to the non-specific nature of anti-cancer drugs, they might attack those healthy cells as well, resulting in the failure of conventional chemotherapy. The lack of selectivity of common anti-cancer drugs lead to their most common side effects including; hair loss, vomiting, fatigue and the risk of developing various infections [2] . In addition, multi drug resistance is a main complication to effective chemotherapy, where cancer cells develop resistance against cytotoxic drugs during or shortly after commencement of therapy [3] .…”

“…Consequently, providing innovative drug delivery systems with novel drug carriers for the already available anti-cancer drugs, with effective drug loading, is quite essential for targeting drug release into the tumor environment [4] , [5] , [6] . Among the recent potential delivery carriers are; polymeric particles [7] , nanomaterials, microspheres [8] , dendrimers [9] , liposomes [10] , and carbon nanotubes [2] . Nanocarriers allow the adjustment of drug release rate, alter drug distribution in vivo, and enhance drug efficiency through encapsulation and absorption [ 2 , 11 ].…”

“…Among the recent potential delivery carriers are; polymeric particles [7] , nanomaterials, microspheres [8] , dendrimers [9] , liposomes [10] , and carbon nanotubes [2] . Nanocarriers allow the adjustment of drug release rate, alter drug distribution in vivo, and enhance drug efficiency through encapsulation and absorption [ 2 , 11 ].…”

“…DOX recognized adverse side effects; include cardiotoxicity, nephrotoxicity, alopecia, vomiting, leukopenia, and stomatitis [18] . Also, intravenous administration of DOX is quite difficult as a result of its low solubility in aqueous media [2] . DOX kills cells by preventing DNA replication and subsequent cell division [36] .…”