A possible case of Garre’s sclerosing osteomyelitis from Medieval Tuscany (11th–12th centuries)

Giuffra, Valentina; Vitiello, Antonio; Giusiani, Sara; Caramella, Davide; Fornaciari, Gino

doi:10.1016/j.ijpp.2015.09.002

Cited by 4 publications

(3 citation statements)

References 17 publications

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“…However, the involvement of long bones, such as the femur and tibia, has also been reported in the literature [ 4 ]. This condition mainly affects children and young adults, with only a few cases of adults reported in the literature [ 2 , 3 , 5 - 7 ]. It commonly occurs before the age of 25 years due to the peak of periosteal osteoblastic activity [ 8 ], with a mean onset age of 16 years [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

“…After a thorough literature review, we only found five cases of Garré’s sclerosing osteomyelitis of the tibia in adult patients [ 2 , 3 , 5 - 7 ]. Only two of these were males [ 5 , 7 ], and no instances of Hispanics have been reported before. This study aims to report a rare case of sclerosing osteomyelitis of Garré affecting the left anterior tibia midshaft of a 25-year-old adult Hispanic male, whose diagnosis was made by clinical-radiological correlation and biopsy.…”

Section: Introductionmentioning

confidence: 99%

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Garré’s Sclerosing Osteomyelitis of the Tibia in a Hispanic Adult Male: A Case Report

Sanchez-Fernandez,

Claudio-Marcano,

Gonzalez-Ugarte

et al. 2024

Cureus

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Sclerosing osteomyelitis of Garré is a rare inflammatory pathology characterized by cortical thickening and loss of the medullary canal. Typically, this pathology affects the mandible. However, the involvement of long bones, such as the femur and tibia, is also possible. This condition predominantly affects children and young adults, especially females, and commonly emerges before age 25, with an average onset age of 16 years. The disease is characterized by an insidious onset, causing local pain, distention of the affected bone, and a moderately increased erythrocyte sedimentation rate. We aim to report a unique case involving a 25-year-old Hispanic male presenting with a one-year insidious onset of left anterior lower leg pain. The patient’s clinical course, laboratory findings, and imaging results are discussed. Despite a three-month trial of conservative management, symptomatic relief was elusive, prompting a left tibia core biopsy. Biopsy results revealed an inflammatory-reactive process with a xanthogranulomatous reaction. The continuation of conservative measures post-biopsy led to significant symptom resolution, highlighting the potential efficacy of histopathological examination. This case contributes to the limited literature on adult sclerosing osteomyelitis of Garré, particularly in long bones and among Hispanic individuals. Successful management through biopsy and conservative treatment provides valuable insights into therapeutic options for this rare condition.

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