A potential side effect of oral topical steroids: Central serous chorioretinopathy

George, Saranya; Balan, Anita

doi:10.4103/ijdr.ijdr_694_16

Cited by 12 publications

(8 citation statements)

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“…To the best of our knowledge, one other published case of CSR accompanying the administration of oral topical corticosteroid exists in the literature, wherein George and Balan reported that a patient using 0.1% triamcinolone acetonide, a less potent medication, showed significant improvement in ocular symptoms following discontinuation of the oral gel 2 months later [16].…”

Section: Discussionmentioning

confidence: 99%

“…Although the pathogenesis remains unknown, risk factors associated with CSR include type A personality [2], Cushing disease [3, 4], pregnancy [5], and exposure to exogenous corticosteroid use [6]. Previous cases of CSR have been reported following the use of systemic [7], epidural [8], intranasal [9], peri-ocular [10], intra-articular [11], and topical dermal corticosteroids [12–15], along with one case of 0.1% oral topical triamcinolone acetonide gel [16].…”

Section: Introductionmentioning

confidence: 99%

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Central serous retinopathy associated with topical oral corticosteroid use: a case report

et al. 2019

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Background Oral topical corticosteroid gels are widely used in dental medicine. Case studies of central serous retinopathy have been reported following administration of corticosteroids, but none so far coinciding with the use of topical fluocinonide gel. This case report further contributes to the database of potential risks of corticosteroid use. Case presentation A 40-year-old South Asian woman presented with decreased vision, pigment epithelial detachments, and serous retinal detachments in both eyes 1 month after starting treatment with topical fluocinonide 0.05%, a topical oral corticosteroid gel. Her condition resolved 6 months after discontinuing the use of the steroid. Conclusions To the best of our knowledge, this is the first case of idiopathic central serous retinopathy associated with the use of oral fluocinonide gel. Discontinuing the use of the steroid may result in resolution of the serous retinal detachment and improvement of visual symptoms. Patients and their doctors who prescribe this medication should be aware of this association.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Central serous retinopathy associated with topical oral corticosteroid use: a case report

et al. 2019

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“…The notable side effects of corticosteroids are oral candidiasis, hypogeusia, drug hypersensitivity, secondary adrenal insufficiency, hypothalamic-pituitary-adrenal axis inhibition and central serous chorioretinopathy. [8] Therefore, there is a need for better topical agents for the treatment of oral ulcers, which could prove rational and more efficacious in treating oral ulcers with minimal or no side effects, when compared to corticosteroids. As oral administration of vitamins is accompanied by positive oral mucosal health, great therapeutic index and minimal side effects, [9] Vitamin B9 or folic acid has shown to play a fairly positive role as far as gingival and oral mucosal health is concerned.…”

Section: Introductionmentioning

confidence: 99%

Comparative study for safety and efficacy of a novel folic acid formulation gel with 0.1% triamcinolone acetonide paste in experimentally induced oral ulcer

Rashid¹,

Rahman

Khan

2021

IJPP

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Objectives: The objective of the present study was to evaluate the efficacy and safety of 0.1% novel folic acid gel in blunt dental instrument-induced oral ulcer in animal models (both rats and rabbits). Materials and Methods: The study was conducted in the Experimental Laboratory, Department of Pharmacology, Jawaharlal Nehru Medical College, Aligarh Muslim University. Animals were randomly divided into three interventional groups, namely Group 1 (folic acid gel), Group 2 (triamcinolone oromucosal paste) and Group 3 (control). We created a linear oral ulcer of 5 mm with the blunt dental instrument in both rats and rabbits. Each group consists of 10 animals (6 rats + 4 rabbits). Group 1 received test drug 0.1% novel folic acid gel formulated by us, Group 2 was positive control and received standard local drug 0.1% Kenacort triamcinolone oromucosal paste and Group 3 served as a negative control group where no treatment was given. Results: No untoward reaction was observed on the irritancy test. Kruskal–Wallis test applied for comparison of results. After 1 week of post-ulcer induction, there was a marked improvement in healing of oral ulcers in both Group 1 and Group 2, but more statistically significant healing was seen in Group 1 (folic acid gel). Both Groups 1 and 2 showed steady improvement in the healing of oral ulcers as compared to their pre-treated values and again were more marked in Group 1. Conclusion: Local folic acid gel supplementation was safe and had shown to augment oral ulcer healing in rats and rabbit’s animal models.

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“…Pathogens 2020, 9, 952 2 of 13 A major clinical challenge of OLP for clinicians is providing patients with successful management or treatment without negative side effects. Currently, one of the most common treatments for OLP is topical corticosteroids [6]. Topical therapy is commonly favored over systemic therapy as the former is easier and more cost-effective when compared to the latter.…”

Section: Introductionmentioning

confidence: 99%

Genomic Analysis of Oral Lichen Planus and Related Oral Microbiome Pathogens

et al. 2020

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Oral lichen planus (OLP) is a common chronic inflammatory disease affecting the oral mucosa. The pathogenesis of OLP is incompletely understood but is thought to be related to the immune system. As the oral cavity is a major reservoir and transmission gateway for bacteria, viruses, and fungi, the microbial composition of the oral cavity could play a role in the pathogenesis of OLP. However, limited by analytic technology and knowledge of the microbial community in the oral cavity, it is not yet clear which pathogens are associated with OLP. Next generation sequencing (NGS) is a powerful tool to identify pathogens for many infectious diseases. In this study, we compared the host cell gene expression profiles and the microbial profiles between OLP patients and matched healthy individuals. We identified the activation of the hepatocyte nuclear factor alpha (HNF4A) network in OLP patients and potential pathogens, including Corynebacterium matruchotii, Fusobacterium periodonticum, Streptococcus intermedius, Streptococcus oralis, and Prevotella denticola. Prevotella denticola is capable of activating the HNF4A gene network. Our findings shed light on the previously elusive association of OLP with various diseases like hepatitis, and indicate that OLP is a T-helper type 17 (Th17) mediated mucosal inflammatory process. The identified molecular pathways and microbes could be used to inform future investigations into OLP pathogenesis and to develop novel therapeutics for OLP treatment.

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A potential side effect of oral topical steroids: Central serous chorioretinopathy

Cited by 12 publications

References 0 publications

Central serous retinopathy associated with topical oral corticosteroid use: a case report

Central serous retinopathy associated with topical oral corticosteroid use: a case report

Comparative study for safety and efficacy of a novel folic acid formulation gel with 0.1% triamcinolone acetonide paste in experimentally induced oral ulcer

Genomic Analysis of Oral Lichen Planus and Related Oral Microbiome Pathogens

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