A Practical Integrated Approach to Supramolecular Chemistry. I. Equilibria in Inclusion Phenomena.

Hernández-Benito, Jesús; González‐Mancebo, Samuel; Calle, Emilio; García-Santos, M. Pilar; Casado, Julio

doi:10.1021/ed076p419

Cited by 18 publications

(9 citation statements)

References 9 publications

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“…A UV-vis spectrophotometric investigation of the interaction between thymol and β-CD was performed. To determine the apparent formation constant (K F ) of the thymol-β-CD complex, experimental data were analyzed using the Benesi-Hildebrand method [40]. According to this approach, the dissociation constant of the complex can be calculated by Eq.…”

Section: Spectrophotometric Measurementsmentioning

confidence: 99%

Electrochemical and associated techniques for the study of the inclusion complexes of thymol and β-cyclodextrin and its interaction with DNA

Lozano

Ferreira

Silva

et al. 2017

J Solid State Electrochem

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Thymol, a potent agent for microbial, fungal, and bacterial disease, has low aqueous solubility and it is genotoxic, i.e., is capable of damaging deoxyribonucleic acid (DNA). This possible problem of DNA toxicity needs to be solved to allow the use of different doses of thymol. This study characterized the inclusion compound containing thymol and β-cyclodextrin (β-CD) by measuring the interaction between these two components and the ability of thymol to bind DNA in its free and β-CD complexed form. The encapsulation approach using β-CD is particularly useful when controlled target release is desired, and a compound is insoluble, unstable, or genotoxic. The interaction between thymol and DNA has been studied using electrochemical quartz crystal microbalance (EQCM), atomic force microscopy (AFM), and differential pulse voltammetry (DPV). The characterization of the inclusion complex of thymol and β-CD was analyzed by UV-vis spectrophotometry, cyclic voltammetry, and scanning electrochemical microscopy (SECM). Based on the free β-CD by spectrophotometry method, the association constant of thymol with the β-CD was estimated to be 2.8 × 10 4 L mol −1 . The AFM images revealed that in the presence of small concentrations of thymol, the dsDNA molecules appeared less knotted and bent on the mica surface, showing significant damage to DNA. The SECM and voltammetry results both demonstrated that the interaction of thymol-β-CD complex was smaller than the free compound showing that the encapsulation process may be an advantage leading to a reduction of toxic effects and increase of the bioavailability of the drug.

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Section: Spectrophotometric Measurementsmentioning

confidence: 99%

Electrochemical and associated techniques for the study of the inclusion complexes of thymol and β-cyclodextrin and its interaction with DNA

Lozano

Ferreira

Silva

et al. 2017

J Solid State Electrochem

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“…If [C] 0 and [S] 0 are the initial b-CD and substrate concentrations, respectively, the dissociation constant of the complex can be calculated according to the Benesi-Hildebrand method [36] (Eq. (3)): (Fig.…”

Section: In the Presence Of Ethanolmentioning

confidence: 99%

Electrochemical activation of β-lapachone in β-cyclodextrin inclusion complexes and reactivity of its reduced form towards oxygen in aqueous solutions

Abreu

Ferreira

Goulart

et al. 2007

Journal of Electroanalytical Chemistry

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“…In a previous paper (1) we proposed an experiment for detecting the inclusion of an azo-dye with α-cyclodextrin and measuring the equilibrium constant of the formation of the corresponding inclusion complex. In this article we study the kinetics of the formation of that inclusion complex of the guest molecule, mordant yellow 7 (MY7), 3-methyl-5-(4-sulfophenylazo)salicylic acid, disodium salt, in the host molecule, α-cyclodextrin.…”

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confidence: 99%

A Practical Integrated Approach to Supramolecular Chemistry. II. Kinetics of Inclusion Phenomena

et al. 1999

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A Practical Integrated Approach to Supramolecular Chemistry. I. Equilibria in Inclusion Phenomena.

Cited by 18 publications

References 9 publications

Electrochemical and associated techniques for the study of the inclusion complexes of thymol and β-cyclodextrin and its interaction with DNA

Electrochemical and associated techniques for the study of the inclusion complexes of thymol and β-cyclodextrin and its interaction with DNA

Electrochemical activation of β-lapachone in β-cyclodextrin inclusion complexes and reactivity of its reduced form towards oxygen in aqueous solutions

A Practical Integrated Approach to Supramolecular Chemistry. II. Kinetics of Inclusion Phenomena

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