A preliminary evaluation of effects of high doses of Jujube and Saffron on biochemical and hematological parameters in rats

Abstract

We investigated effects of high doses of Jujube fruits and Saffron petals on biochemical and hematological biomarkers in rats. During 14 days treatment of herbs, mortality was not observed. No difference reported in FBS, lipid profile, total protein, albumin, total bilirubin and hematological parameters of rats after treatments. BUN, cratinine, urate and liver enzymes levels in both extracts increased. These changes were more noticeable in Saffron compared with Jujube. This study can suggest that administration of high doses of Jujube (up 5000 mg/kg) and Saffron (up 2000 mg/kg) are nearly safe, also did not exert hepato and nephrotoxicity in rats.

Fabrication and characterization of jujube extract‐loaded electrospun polyvinyl alcohol nanofiber for strawberry preservation

“…( 2014 ) and Koley et al ( 2016 ) reported the estimated flavonoid content of Apple kul (Zizyphus Mauritiana) and Indian Zizyphus as (13.19 ± 1.31 mg CEQ/100 g) and (13.09 ± 3.93 mg CEQ/100 g), respectively, which was similar to our study values (Afroz et al., 2014 ; Koley et al., 2016 ). It was reported that total phenolic content of jujube (2.5 g/L) was 220 ± 2.76 GAE/g DW (Safizadeh et al., 2017 ). Hudina et al ( 2014 ) found that extract of Chinese jujube contained two phenolic acids (chlorogenic acid and caffeic) and three flavonoids (catechin, epicatechin, and rutin) (Hudina et al, 2014 ).…”

“…1 Whatman filter paper. Eventually, the samples lyophilized by freeze dryer (Dena, model: FD‐50F series, Iran) at −80℃ for 24 h (Safizadeh et al., 2017 ). For determination of antioxidant activity and total phenol and flavonoid contents, 5, 10, 15, and 20 g/ml concentrations were used.…”

Alteration in hematological profile of pregnant crossbred cattle of Assam after feeding some medicinal leaves/herbs and polyherbal preparation (Restobal) during their transition period.

“…Sivajoth et al (2018) [27] reported significant elevation in the total leukocyte count and lymphocyte count compared with the buffaloes in group I on 5th day of therapy. Safizadeh (2017) [23] investigated the effects of high doses of Jujube fruits and Saffron petals on hematological biomarkers in rats. No difference reported in hematological parameters of rats after treatments and the study suggested that administration of high doses of Jujube do not exert any toxic effect.…”