The application of FactSage software in phosphogypsum resource utilization is described. Thermodynamic analysis is not only useful for predicting the amount and type of products including gases and solids under various conditions, but also for investigating the thermodynamic properties of related reactions. Statistical data analysis is conducted using the equilib module, reaction module, and phase diagram module of FactSage. The optimal conditions and mechanisms to utilize phosphogypsum for its products CaS, CaO, and CaCO3 are summarized. This comprehensive review on thermodynamic analysis in phosphogypsum resource utilization for the mentioned products is valuable for academicians, scientists, and researchers.