A Prospective Review on Phyto-pharmacological Aspects of Vitex negundo Linn

Abstract

Background: Vitex negundo Linn. commonly known as five leave chase tree is an ethnobotanically important drug in traditional system of medicine. The plant is widely distributed in India, China and other Asian and American countries. Objective: The review aims at presenting comprehensive information with respect to ethnopharmacological rele-vance and recent findings on phytochemical and biological activities of Vitex negundo. Method: Literature was collected from various sources such as pubmed, scopus, science direct, and others. Results: Extracts and secondary metabolites of this plant, particularly those from roots and leaves, possess useful pharmacological activities such as anti-inflammatory, antitumor, antioxidant, antimicrobial, galactagogue, antigas-tric, antiflatulant, antiparasitic, analgesic, hepatoprotective and antihypertensive, some of which have been vali-dated scientifically. All parts of plant especially leave and roots contain a large number of bioactive phytoconstitu-ents including flavonoids, iridoids, lignans, volatile oil, terpenes, coumarins, phenolic and steroidal compounds which impart it multiple medicinal properties. Vitexin, isovitexin, viridifol, caffeic acid, chlorogenic acid and iso-chlorogenic acid are the main components. Conclusion: The review emphasises the medicinal importance of Vitex negundo and its bioactive constituents in traditional system of medicine.

Vitex doniana L. Growing in Southwestern Nigeria: Leaf Essential Oil Composition and Antimicrobial Activity

“…The genus Vitex (Lamiaceae) is made up of 233 recognized species, 1 dominated by trees and shrubs, found in tropical and sub-tropical regions. 2,3 Common species used in ethnobotanical medicine include V. agnus-castus L., 4 V. negundo L., 5 V. rotundifolia L., 6 and V. trifolia L. 7 Vitex doniana Sweet (black plum) is a deciduous flowering tree growing up to 20 m height in the forests of coastal tropical west Africa. It is recognized with long-stalked leaves rounded at the apex with a glabrous leaflet and edible fruits.…”

Antibacterial and fungicidal activities of ethanol extracts of 38 species of plants

“…The notable inhibiting activity of extract of this plant was due to its high content of phenols and flavonoids (Prashith & Raghavendra, 2014). Extracts and secondary metabolites of V. negundo, especially from the roots and leaves, have useful pharmacological properties: anti-inflammatory, anti-tumour, antioxidant and antimicrobial (Tan et al, 2017;Khan et al, 2019). Use of V. negundo may be promising for treatment of skin infections caused by Staphylococcus aureus (Triveni & Gaddad, 2016).…”

“…Emergence of resistance to antibiotics in bacteria is a global problem (Lopes et al, 2018;Zhang et al, 2019). Antibiotic-resistance is now one of the most serious threats to the health of people (Steinberg et al, 2017;Tumen et al, 2018;Khan et al, 2019). Our civilization is approaching the period when antibiotics will be unable to control the courses of common infections, and small traumas could once more lead to people dying (Islam et al, 2019).…”

A Systematic Comparative Study of Morinda Tinctoria and Vitex Negundo for their Anti-Ulcerogenic Potential

“…Nirgundi, Sambhalu, or monk's paper are all names for Vitex negundo L. It grows in wet locations, often along river banks, in India up to a height of 1500 gigameters as well as in the Mediterranean and Central Asian regions. It is thought to offer several medicinal properties, as well as antiulcer properties (Ullah et al, 2012;Vangoori et al, 2013;Gill et al, 2018;Chandra & Meel, 2020;Júnior et al, 2020;Devi, 2021;Jongjai et al, 2021;Khan et al, 2021;Neha et al, 2021;Gouthami et al, 2022;Mehta et al, 2022;Tasfiyati et al, 2022;Vannur et al, 2022;Wang et al, 2022).…”