A prospective study evaluating wound healing with sea cucumber gel compared with hydrogel in treatment of skin graft donor sites

Wen, Adzim Poh Yuen; Halim, Ahmad Sukari; Saad, Arman Zaharil Mat; Nor, Fatimah Mohd; Sulaiman, Wan Azman Wan

doi:10.1016/j.ctim.2018.10.006

Cited by 12 publications

(4 citation statements)

References 20 publications

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“…In the present study, we found that sea cucumber was more effective in reducing skin maceration in periwound skin of DFU than honey over four weeks. According to previous studies, effectiveness of wound healing of sea cucumber was reported in rats' burn wounds (Zohdi et al, 2011), DFU mice wounds intragastrically administered (Li et al, 2018), and human skin graft donor sites wound (Poh Yuen Wen et al, 2018). To these evidences, our study could add the new evidence for the clinical use in DFU wound care.…”

Section: Effectivenessmentioning

confidence: 63%

Effect of Sea Cucumber on Reducing Periwound Maceration and Inflammation-Related Indicators in Patients with Diabetic Foot Ulcers Indonesia

Haryanto

Arisandi

et al. 2022

INJEC

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Introduction: Maceration is one of the problems affecting the healing process of diabetic foot ulcers (DFUs). In complementary therapies, sea cucumber is known to have higher absorbency. However, there are few studies on the reducing of periwound maceration and inflammation-related indicators in DFU.Methods: This was an observational study at a wound care clinic in Indonesia. Thirty-one DFU patients received treatment with sea cucumber were enrolled in the study. As control samples, 35 DFU patients treated with honey were also included. All were new occurrence DFU and had maceration at the baseline. The maceration area and inflammation-relate indicators including TNF-, MMP-2, and MMP were measured on baseline and week 4.Results: There were no significant differences between two groups at the baseline. In the multiple linear regression model, sea cucumber significantly associated with the proportion of maceration reduction than honey at week 4 (β＝0.520, p=0.001). There were no significant differences between two groups in levels on TNF-α, MMP-2, and MMP at week 4.Conclusions: Our results demonstrated that sea cucumber might be appropriate for reducing DFU periwound maceration.

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Section: Effectivenessmentioning

confidence: 63%

Effect of Sea Cucumber on Reducing Periwound Maceration and Inflammation-Related Indicators in Patients with Diabetic Foot Ulcers Indonesia

Haryanto

Arisandi

et al. 2022

INJEC

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“…Gamat hydrogel also improved histological reorganization of regenerating tissue, modulated inflammatory response, fibroblast proliferation, collagen production, and reduced proinflammatory cytokines. 133 A study by Poh Yuen Wen et al 134 found no difference in rates of epithelialization between sea cucumber dressing and other hydrogel dressings. Because most of the studies on rats showed benefits without significant adverse effects, and the gamat hydrogel is sold commercially, 133,135 clinical trials can be done to assess its efficacy in humans.…”

Section: Animal Productsmentioning

confidence: 99%

Review of Traditional First Aid for Burn Injuries in the 21st Century

Hafizurrachman,

Menna,

Lesmana

2023

Ann Plast Surg

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Introduction This review aims to investigate data on traditional burn first aid materials used in different countries. Methods A systematic search was performed through 8 databases for studies on traditional burn first aid published in the 21st century. Data regarding study demographics, burn first aid, first aid materials, water irrigation, and source of knowledge were summarized, and the use of each material was discussed. Results A total of 28 studies including 20,150 subjects were identified. An average of 29% of the study population applied water irrigation, whereas 46% used various traditional materials, and 30% did not administer first aid. People with higher education and socioeconomy class tend to choose correct first aid actions. Discussion The single best treatment as burn first aid is cool-water irrigation. Despite that, various other materials have been used, most of which are not suitable for first aid. Some materials possess healing abilities and can be used as wound dressing, whereas others are harmful. Inappropriate materials are mostly used in underdeveloped regions lacking water access and hygiene. Mass media and community knowledge have a large influence in burn first aid practices. Conclusion Raising public health awareness on burn first aid is crucial along with providing the people access to water, basic hygiene, and health care.

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“…In truth, hydrogel penetration through the skin seems unlikely as the macroscale mesh-like structure would prohibit penetration and has been shown, in the case of collagen hydrogels, to not even affect burn models [197]. Various alternative hydrogel formulations are commonly tested on graft donors with no discernable side effects compared to other gel-based formulations commonly used in hospital environments [198]. Recent studies demonstrated that this method of delivery is reliable as a delivery system for nanoparticles with various roles, and it only depends on nanoparticles diameter, charge, and structure.…”

Section: Hydrogel Administrationmentioning

confidence: 99%

Hydrogels Based Drug Delivery Synthesis, Characterization and Administration

et al. 2019

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Hydrogels represent 3D polymeric networks specially designed for various medical applications. Due to their porous structure, they are able to swollen and to entrap large amounts of therapeutic agents and other molecules. In addition, their biocompatibility and biodegradability properties, together with a controlled release profile, make hydrogels a potential drug delivery system. In vivo studies have demonstrated their effectiveness as curing platforms for various diseases and affections. In addition, the results of the clinical trials are very encouraging and promising for the use of hydrogels as future target therapy strategies.

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A prospective study evaluating wound healing with sea cucumber gel compared with hydrogel in treatment of skin graft donor sites

Cited by 12 publications

References 20 publications

Effect of Sea Cucumber on Reducing Periwound Maceration and Inflammation-Related Indicators in Patients with Diabetic Foot Ulcers Indonesia

Effect of Sea Cucumber on Reducing Periwound Maceration and Inflammation-Related Indicators in Patients with Diabetic Foot Ulcers Indonesia

Review of Traditional First Aid for Burn Injuries in the 21st Century

Hydrogels Based Drug Delivery Synthesis, Characterization and Administration

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