A Prospective Study of Liver Enzyme and Other Changes following Repeat Administration of Halothane and Enflurane

Fee, J. P. H.; Black, G. W.; Dundee, John W.; McILROY, P.D.A.; Johnston, H.M.L.; Johnston, S. B.; Black, Ian H.; Mcneill, H.G.; Neill, D. W.; Doggart, J.R.; Merrett, J. D.; McDonald, Jay R.; Bradley, Danessa; Haire, Margaret; McMillan, S A

doi:10.1097/00132586-198012000-00025

Cited by 4 publications

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“…However, the metabolism of en¯urane has been suspected of producing tissue cell degeneration; when accompanied by reduced oxygen tension. 7 Van Dyke et al 8 hypothesized that perhaps the mechanism of liver toxicity associated with anaesthesia, at least in this animal model, is related more directly to severe hypoxia than to a direct toxic intermediate produced as a result of metabolism. A study of Fee et al 7 reported that liver enzyme concentrations increased after anaesthesia had returned to within normal limits before subsequent administrations.…”

Section: Introductionmentioning

confidence: 80%

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The levels of some antioxidant vitamins, glutathione peroxidase and lipoperoxidase during the anaesthesia of dogs

Nazıroğlu

Günay

1999

Cell Biochem. Funct.

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The aim of this investigation was to determine serum levels of vitamin A, E, beta carotene, glutathione peroxidase (GSHPx), lipid peroxidation (MDA) and biochemical and haematological parameters during enflurane anaesthetised dogs. Ten kangal dogs were used and all animals were anaesthetised with enflurane for two hours and blood samples were taken before and 30, 120 minutes, 24 hours and 7 days during the anaesthesia. Vitamin E and beta carotene content were significantly (p<0.05 and p<0.01) higher before anaesthesia than after whereas serum GSHPx activity was not statistically different. However, serum levels of vitamin A and MDA were significantly (p<0.05) increased during the anaesthesia. In general, serum levels of aspartate aminotransferase, alanine aminotransferase, albumin, glucose, urea and creatinine were significantly (p<0.05 and p<0.01) increased during anaesthesia and returned to near normal values after 7 days of anaesthesia, whereas the white blood cell count was significantly (p<0.05 and p<0.01) decreased during the anaesthesia. However, the red blood cell count, haemoglobin and packed cell volume values, and levels of total cholesterol, triglycerides, total protein and globulin were apparently not influenced by the anaesthesia. In conclusion, we observed that the serum level of vitamin E and beta carotene were significantly decreased, whereas serum MDA and vitamin A levels were significantly increased during the enflurane anaesthesia.

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Section: Introductionmentioning

confidence: 80%

“…In addition, these results were also supported by the results of similar studies. 7,8,10,20 There is very close relationship between free radical production and glucose metabolism in animals and humans. For example, diabetes mellitus is a syndrome initially characterised by a loss of glucose homeostasis.…”

Section: Resultsmentioning

confidence: 99%

The levels of some antioxidant vitamins, glutathione peroxidase and lipoperoxidase during the anaesthesia of dogs

Nazıroğlu

Günay

1999

Cell Biochem. Funct.

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“…Repeated halothane exposures are stated to increase the risk of liver damage, and yet hundreds of patients have received repeated halothane anesthetics without a single case of clinical hepatitis. 30 Currently, the only absolute contraindication to the use of halothane is a history of unexplained fever and jaundice after a previous exposure to halothane. Obviously, other factors are involved in the production of "halothane hepatitis.…”

Section: Hepatic Toxicitymentioning

confidence: 99%

A Review of Postoperative Liver Dysfunction

Davies

1983

Ann Saudi Med

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“…More recently, an association has also been suggested between repeated halothane administration and liver damage.I0-l3. Enflurane has similar physical and anaesthetic properties to halothaneI4 but is claimed to be less dysrhythmogenic15 l9 and to be potentially less toxic to the liver, even with repeated administrations at short intervals.20 22 It should, therefore, be superior to halothane in dental outpatient anaesthesia. A clinical trial was designed to compare the use of these two agents in a busy dental anaesthetic practice.…”

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confidence: 99%