The levels of some antioxidant vitamins, glutathione peroxidase and lipoperoxidase during the anaesthesia of dogs

Nazıroğlu, Mustafa; Günay, Cihan

doi:10.1002/(sici)1099-0844(199909)17:3<207::aid-cbf830>3.0.co;2-3

Cited by 29 publications

(28 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Similar data were also reported in dogs anaesthetized by xylazine and ketamine, however no duration of surgery was given (Gunay et al 2011). MDA increased 30 minutes after but did not change 2 and 24 h after exposure of enflurane anaesthesia for 2 hours in dogs, whereas GSH concentration displayed no significant difference (Naziroglu and Gunay 1999). Moreover, Alva et al (2006) reported that one hour exposure of xylazine and ketamine or pentobarbital-induced anaesthesia which was given every 30 minutes for maintenance of anaesthesia did not alter MDA levels at 15 and 60 minutes, while GSH decreased.…”

Section: Discussionmentioning

confidence: 99%

Comparison of flunixin meglumine and meloxicam influence on postoperative and oxidative stress in ovariohysterectomized bitches

Yilmaz¹,

Korkmaz²,

Jaroszewski³

et al. 2014

Polish Journal of Veterinary Sciences

View full text Add to dashboard Cite

The aim of this study was to compare the effect of flunixin meglumine (FM) and meloxicam (M) on postoperative and oxidative stress in ovariohysterectomized bitches. Twenty four bitches were divided into three groups (n=8 in each) and treated during premedication as follows: FM (2.2 mg/kg, iv, Fluvil, Vilsan, Turkey), M (0.2 mg/kg, sc, Maxicam, Sanovel, Turkey) or 0.9% saline (1 ml, iv, IE, Turkey) -control (C) group. The concentrations of serum cortisol, nitric oxide (NO), malondialdehyde (MDA), antioxidant potential (AOP) and glutation (GSH) were measured in blood samples collected during incision (0 h), closure of incision line (0.5 h) and 1, 2.5, 12 and 24 hours after incision. It was observed that cortisol level was higher at 0.5, 1 and 2.5 h in group C (p < 0.05), 0.5 h in group FM (p < 0.001), and 1 and 2.5 h in group M (p < 0.01), as compared to that determine at 0 h. Group C showed higher cortisol level during 0.5 h (p < 0.05) than that found in the other groups. Group FM displayed lower levels during 1 h (p < 0.01) and 2.5 h (p < 0.05) as compared to those observed in other groups. Concentrations of MDA, AOP and GSH between all the groups did not show any significant differences. MDA level was higher at 0.5 and 1 h in group M (p < 0.05) than that found in group C and it was the lowest at 2.5 h in group C (p < 0.05). AOP was higher at 2.5 h in group FM and M (p < 0.05) than that observed in group C, and at 12 and 24 h in group M than that found in group C and FM. GSH did not show any significant differences between the groups. NO level in group FM after 12 h was higher (p < 0.05) than that at 0.5, 1 and 24 h. Moreover, NO level was lower at 0.5 (p < 0.01), 1 (p < 0.05) and 24 h (p < 0.05) in group FM than that observed in group C and M. In conclusion, flunixin meglumine decreases cortisol and NO levels more efficiently than meloxicam. Therefore, it is suggested that postoperative stress following ovariohysterectomy may be prevented by flunixin meglumine in bitches.

show abstract

Section: Discussionmentioning

confidence: 99%

Comparison of flunixin meglumine and meloxicam influence on postoperative and oxidative stress in ovariohysterectomized bitches

Yilmaz¹,

Korkmaz²,

Jaroszewski³

et al. 2014

Polish Journal of Veterinary Sciences

View full text Add to dashboard Cite

show abstract

“…Anestezi esnasında; hipoksinin, antioksidan vitamin ve ya enzim düzeyinin azalmasının hücresel seviyede oksidan/antioksidan dengesinin bozulmasına yol açabileceği düşünülmektedir. 12 Desfluran hepatotoksisitesi için özgül bir radikal bulunmamasına rağmen, antioksidan vitamin ya da enzim seviyelerinde değişikliğe neden olan dolaylı bir etki ile hepatotoksisitenin geliştiği gösterilmiştir. 12,13 Ça-lışmamızda oksidatif stres değerlendirilirken, antioksidan gösterge olarak, büyük oranda karaciğerde sentez edilip salgılanan PON1 temel alın-mıştır.…”

Section: Discussionunclassified

“…12 Desfluran hepatotoksisitesi için özgül bir radikal bulunmamasına rağmen, antioksidan vitamin ya da enzim seviyelerinde değişikliğe neden olan dolaylı bir etki ile hepatotoksisitenin geliştiği gösterilmiştir. 12,13 Ça-lışmamızda oksidatif stres değerlendirilirken, antioksidan gösterge olarak, büyük oranda karaciğerde sentez edilip salgılanan PON1 temel alın-mıştır. 30,31 Primer olarak organafosfat detoksifikasyonunda rol alan PON1, doğal antioksidan bir enzim olarak kabul edilmektedir.…”

Section: Discussionunclassified

“…11 Yapılan çalışmaların bir kısmı, halotan ve desfluranın değişik dokuların oksidatif sistemi üzerinde negatif bir etkiye sahip olduğunu gösterirken, herhangi bir değişikliğe yol açmadı-ğını veya pozitif bir etkiye sahip olduğunu bildiren çalışmalar da mevcuttur. [11][12][13][14] Literatürde desfluranın hepatik ve antioksidan sisteme etkisi incelenmiş olmasına rağmen, tekrarlayan desfluran uygulamalarının özellikle yaşlı-larda karaciğer üzerindeki etkisinin doku ve plazma paraoksonaz (PON1) enzim düzeyleri ile ilişkisi araştırılmamıştır. 11,[14][15][16] Bu nedenle, bu çalış-mada, yaşlı sıçanlarda tekrarlanan desfluran anestezisi uygulamaları sonucunda karaciğerde ortaya çıkan histopatolojik değişimlerin plazma PON1, aspartat aminotransferaz (AST) ve alanin aminotransferaz (ALT) enzim aktivitelerinin, karaciğer dokusu PON1 aktivitesi ve malondialdehit (MDA) düzeyi ile ilişkisinin araştırılması amaçlanmıştır.…”

unclassified

See 1 more Smart Citation

The Relation of Paraoxonase Levels with the Histopathology of the Old Rat Liver Tissue After Repeated Desflurane Anesthesia

Cüce¹,

Yosunkaya²,

Borazan³

et al. 2013

Turkiye Klinikleri J Med Sci

View full text Add to dashboard Cite

“…Previous studies in animals have suggested that exposure to volatile anesthetics can induce oxidative stress (Nazirolu and Gunay, 1999;Nazirolu and Cay, 2001). Our body is equipped with ample cache of defenses against reactive oxygen species (ROS).…”

Section: Introductionmentioning

confidence: 99%

Effects of vitamin C on inhalation anesthetic isoflurane-induced developmental, neuronal apoptosis in neonatal rats

Shuai

Wang

Xiong

et al. 2014

Bangladesh J Pharmacol

View full text Add to dashboard Cite

Research ArticleEffects of vitamin C on inhalation anesthetic isoflurane-induced developmental, neuronal apoptosis in neonatal rats BJP IntroductionAbout 200 million patients worldwide are exposed to anesthesia and undergo surgery each year (Weiser et al., 2008;Moonesinghe et al., 2011). Volatile anesthetics such as isoflurane and sevoflurane are used in millions of young children each year during surgical procedures and imaging studies (Istaphanous and Loepke, 2009). Exposure to anesthetic cocktails (Yon et al., 2005;Lu et al., 2006;Sanders et al., 2009) or volatile agents such as isoflurane even as a single anesthetic (Yon et al., 2005;Ma et al., 2007) has been reported to be associated with widespread apoptotic neurodegeneration in the developing brains and contributes to the post-operative cognitive dysfunction (POCD) (Jevtovic-Todorovic et al., 2003;Satomoto et al., 2009;Brambrink et al., 2010;Kong et al., 2011;Paule et al., 2011; Li et al., 2013a,b).In rodent models, the effects of anesthesia have been evaluated following exposure during a time of peak brain development and synaptogenesis, typically at postnatal day 7 (P7) (Jevtovic-Todorovic et al., 2003;Stratmann et al., 2009b;Shih et al., 2012). Apoptosis has been observed to occur acutely in the period immediately following anesthesia (Jevtovic-Todorovic et al., 2003;Istaphanous et al., 2011;Shih et al., 2012), and the thalamus and hippocampus are known areas susceptible to extensive neurodegeneration (JevtovicTodorovic et al., 2003;Satomoto et al., 2009;Shih et al., 2012). AbstractDevelopmental abnormalities, neuronal apoptosis and associated cognitive impairment following isoflurane exposure in neonatal rodents have been reported. The study was undertaken to investigate the effect of vitamin C supplementation against isoflurane-induced neurotoxicity. Seven day old rats were exposed to 1.1% isoflurane, or air for 6 hours. Treatment groups were administered with vitamin C (30 mg/kg, orally) from postnatal day 1 (P1) to P10 and were exposed to isoflurane on P7. Isoflurane exposure induced apoptosis was determined by Fluoro-Jade C and terminal deoxynucleotidyltransferase-mediated 2'-deoxyuridine 5'-triphosphate nick-end labeling assay. Vitamin C considerably improved memory and learning impairments, modulated neuroapoptosis and improved expressions of brain-derived neurotrophic factor, nerve growth factor, Bcl-xL and decreased activated caspase-3 expressions. Thus, vitamin C effectively offered protection against isoflurane-induced neuronal apoptosis, learning and memory disturbances. Article Info

show abstract

The levels of some antioxidant vitamins, glutathione peroxidase and lipoperoxidase during the anaesthesia of dogs

Cited by 29 publications

References 17 publications

Comparison of flunixin meglumine and meloxicam influence on postoperative and oxidative stress in ovariohysterectomized bitches

Comparison of flunixin meglumine and meloxicam influence on postoperative and oxidative stress in ovariohysterectomized bitches

The Relation of Paraoxonase Levels with the Histopathology of the Old Rat Liver Tissue After Repeated Desflurane Anesthesia

Effects of vitamin C on inhalation anesthetic isoflurane-induced developmental, neuronal apoptosis in neonatal rats

Contact Info

Product

Resources

About