2008
DOI: 10.1016/j.ygeno.2007.12.007
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A protein–protein interaction network of transcription factors acting during liver cell proliferation

Abstract: Liver regeneration is a complex process that involves a multitude of cellular functions, including primarily cell proliferation, apoptosis, inflammation, and metabolism. A number of signaling pathways that control these processes have been identified, and cross communication between them by direct protein-protein interactions has been shown to be crucial in orchestrating liver regeneration. Previously, we have identified a group of transcription factors capable of regulating liver cell growth and that may be i… Show more

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Cited by 29 publications
(22 citation statements)
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“…When JUN is not present, JunB can function as a positive growth regulator, but JUN-JunB heterodimers show antiproliferative activity (21). Transcription of ATF3 transcription is increased following hepatic injury, leading to hepatocyte proliferation (15). On the contrary, Fos was found to act as a tumor suppressant in human epithelial hepatocytes by inducing cell cycle inhibition and cell death (32).…”
Section: Discussionmentioning
confidence: 99%
“…When JUN is not present, JunB can function as a positive growth regulator, but JUN-JunB heterodimers show antiproliferative activity (21). Transcription of ATF3 transcription is increased following hepatic injury, leading to hepatocyte proliferation (15). On the contrary, Fos was found to act as a tumor suppressant in human epithelial hepatocytes by inducing cell cycle inhibition and cell death (32).…”
Section: Discussionmentioning
confidence: 99%
“…Proliferation of cells depends on progression through four distinct phases of the cell cycle-G0/G1, S, G2 and M, which are regulated by various proteins interacting in signalling pathways in complexes 2 . The dynamic constitution of protein-protein interactions in signalling pathways is important to coordinate cellular functions in response to extrinsic or intrinsic proliferation signals 3 , 4 .…”
Section: Introductionmentioning
confidence: 99%
“…Resonance energy transfer (FRET) techniques further allow for dynamic measurement of pairwise proximity in solution 18 , 19 . Complementary to microscopy are the biochemical techniques that have enabled ensemble measurements of protein interaction networks with molecular precision, including yeast two-hybrid 20 22 and related 23 assays, affinity purification/mass spectroscopy 24 , and co-immunoprecipitation 25 . They are relatively easily parallelized, executed, and even automated.…”
Section: Introductionmentioning
confidence: 99%