A Pulse Radiolysis Study of an Imidazolato-Bridged Asymmetric Dicopper(II) Complex: A Structural and Functional Mimic of Superoxide Dismutase

Tabbı̀, Giovanni; Nauser, Thomas; Koppenol, Willem H.; Reedijk, J.

doi:10.1002/(sici)1099-0682(199812)1998:12<1939::aid-ejic1939>3.0.co;2-4

Cited by 9 publications

(2 citation statements)

References 36 publications

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“…An imidazolato-bridged asymmetric dicopper complex scavenges superoxide with a very high rate constant consistent with catalytic dismutation. 443 A seven-coordinated Mn II complex scavenges superoxide without catalyzing its dismutation. 444 Radiosterilization of medicines is reported in Section 9.…”

Section: Small Moleculesmentioning

confidence: 99%

7 Radiation chemistry

Belloni

Delcourt

Houée-Levin⊥

et al. 2000

Annu. Rep. Prog. Chem., Sect. C

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We try in this review to survey advances in all the aspects of Radiation Chemistry (the effects of high energy or ionizing radiation), both basic and applied, made during the period 1995^1999, after the last report issued at the end of 1994. 1 Classically, two main classes of studies are relevant. The ¢rst one includes the primary phenomena induced by the interaction of high-energy radiation with a chemical system. The way the energy is spatially deposited is indeed highly nonhomogeneous and depends on the type of radiation considered. Mutual reactions between the primary species produced also depend on their initial spatial distribution, and therefore on the energy absorption pattern. The kinetic aspects derive directly from the initial events following radiation absorption and thus, when observed at times as short as possible, give useful information on the early energy distribution for each of the radiation types, X-and g-photons, electrons and heavy particles, and, on the in£uence of their intensity and energy per particle.The second class of studies utilizes the background knowledge of radiation chemistry to generate and then to observe the fate of chemical transient species known to be involved in very important chemical or biochemical processes. Numerous data, such as the nature of reaction products, the absolute rate constants, the sequence of elementary reactions constituting a mechanism, and the thermodynamic and spectroscopic properties of short-lived species have been attained. This kind of study of transients and reaction mechanisms, which can be approached only by pulse techniques (essentially pulse radiolysis or laser photolysis, each with its speci¢c advantages), constitutes the new ¢eld of fast to ultrafast chemistry. It concerns extended domains of physical, organic, inorganic, and bio-chemistry. Moreover, the understanding of mechanisms is quite helpful in suggesting new ways of synthesis or degradation induced by irradiation and is now extensively used in developing various speci¢c processes in applied chemistry. The number of studies on the chemical mechanisms and in applied radiation chemistry constitutes an increased fraction of the total publications in radiation chemistry, which we estimate to be around 4000 over the period considered (almost constant compared to the preceding 5-year

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Section: Small Moleculesmentioning

confidence: 99%

7 Radiation chemistry

Belloni

Delcourt

Houée-Levin⊥

et al. 2000

Annu. Rep. Prog. Chem., Sect. C

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“…17 Deficient level of SOD concentration in human body is one of the reasons behind diseases and disorders like diabetes, ischemia, cataract, Parkinson's disease, cancer, etc. 18,19 Supplementation of antioxidant enzymes should be a part of the treatment but administration of * For correspondence these enzymes through oral or intraperitonial routes is severely restricted due to their rapid degradation and short life time in biological systems. 20 Small metal complexes having good superoxide scavenging activity are potential candidates in this regard.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, characterization and superoxide dismutase activity of bi-copper(II)-bisacetato- μ−phthalicacid[bis(benzyloxy)ethyl]ester

2015

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A new binuclear copper(II) complex, bridged by the ligand phthalicacid[bis(benzyloxy)ethyl]ester, where each copper(II) is coordinated to one carboxylate (from ligand) and one acetate in square planar mode is reported. The ligand synthesized by the reaction of phthalic anhydride and ethylene glycol, has been characterized by FT-IR, 1 HNMR and LCMS. The binuclear Copper(II) complex has been characterized by UV/visible spectra, FTIR spectra, EPR spectra, ESI-MS spectra, magnetic moment measurement and thermogravimetric analysis. DFT calculation has shown a Z type structure for the complex. Excellent superoxide dismutase activity with IC 50 value 8.6×10 −6 M for the complex has been observed.

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A Study on Some Copper (II) Complexes of Polyaza Cryptands and Planar Macrocycles—Synthesis, Characterization and Superoxide Dismutase Activity

et al. 2001

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Two kinds d macrocyclic copper( II) complexes were synthesized. Oneofthemiscomposedofcopper(II)cryptatesdligandf L'-L' which densation pmducts d I R -2methoxy-l,J-phenyldialdehyde ( R = OCH,, L' ) with his ( 2-amin0ethyl)amine and 5-R-2-methothoxy-1, Iphenyldlaldehyde(R=CH,. L-') withtris(2-aminopropyl)aminemwweilm their reduced ploducts OP L ' and L-' (LZ and L ' ) . be other is composed of two--msQocydic mpper(II) crmplexes d ligands L5-L8 of conderrsatioo products d diethylene t -with QR-l-~tho~y-2.6-phenyldiaklehyde (R = CI, Br. CH3, OCH, ) . Therelatidp between their struchves and superoxide disnutaw (SOD) activity vm investigated.The results can provide some clues to the synthesis of SOD mimics.

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A Pulse Radiolysis Study of an Imidazolato-Bridged Asymmetric Dicopper(II) Complex: A Structural and Functional Mimic of Superoxide Dismutase

Cited by 9 publications

References 36 publications

7 Radiation chemistry

7 Radiation chemistry

Synthesis, characterization and superoxide dismutase activity of bi-copper(II)-bisacetato- μ−phthalicacid[bis(benzyloxy)ethyl]ester

A Study on Some Copper (II) Complexes of Polyaza Cryptands and Planar Macrocycles—Synthesis, Characterization and Superoxide Dismutase Activity

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