A Pyrene Derivative for Hg²⁺‐Selective Fluorescent Sensing and Its Application in In Vivo Imaging

Abstract

An Hg(2+) -selective fluorescent sensor (1) bearing pyrene as a fluorophore was synthesized. A sandwich-stacking binding mode was formed during the binding process, which increased the excimer fluorescence 22-fold at 490 nm. Compound 1 was successfully applied in in vivo imaging to trace the enrichment and distribution of mercury in the nervous system, digestive system, and reproductive system of Caenorhabditis elegans, as well as the organs of zebrafish.

Synthesis and properties of three novel rhodamine-based fluorescent sensors for Hg2+

“…These results could not be explained by the reversible sensing mechanism through amino/oxo/thioxo donor coordination [9,25,26], the irreversible sensing mechanism based on the hydrolysis [27,28] or cyclization reaction [29][30][31], and the sandwich-stacking binding mode [32] reported in the references. Therefore, we conjectured that a new interaction way between Hg 2+ and the sensor might occur.…”

Reactivity of dinuclear copper(II) complexes towards melanoma cells: Correlation with its stability, tyrosinase mimicking and nuclease activity

“…Ligand 2,2′-bis(aminomethyl)diphenyl 2,2′-Bis(aminomethyl)biphenyl (dpam) was prepared in 2 steps by a Gabriel's reaction from 2,2′-bis(bromomethyl)biphenyl [7] according to a described procedure [8]. N-benzyl-N-bis(2-pyridylethyl)amine (N22) was prepared by addition of benzylamine to an excess of 2-vinylpyridine, according to a procedure reported in the literature [9].…”

Firefly Luciferin‐Inspired Biocompatible Chemistry for Protein Labeling and In Vivo Imaging

“…Unraveling these requires am olecular imaging probe, which can offer imaging signals upon interaction with amolecular target of interest, allowing to report on its level and/ora ctivity in living systems. [1][2][3][4] Hence,i ti sc riticalt od evelop efficient methodsf or the construction of high performance molecular imaging probes capable of non-invasive detecting different molecular targets,s uch as intracellular pH, [5,6] ions, [7,8] redox environment, [9][10][11][12][13] DNA, [14,15] and enzymes. [16,17] Over the last two decades, biocompatible reactions have offered promising applications for the design of molecular imaging probes.…”