A Quantitative Study of the Effect of Terfenadine on Cutaneous Erythema Induced by UVB and UVC Radiation

Farr, P.M.; Diffey, Brian; Humphreys, F.

doi:10.1111/1523-1747.ep12457921

Cited by 8 publications

(2 citation statements)

References 12 publications

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“…At 1.4 MED the gel was significantly less effective than the hamamelis lotion with distillate 1. The failure to observe greater efficacy in the UV-induced erythema model is in accordance with most of the available literature since antihistamines have usually been found to be ineffective in this model when applied after irradiation [8][9][10]. However, in a recent study measuring central nervous parameters of sensory and pain thresholds to CO 2 laser stimulation after irradiation with 3 MED, a significant effect of dimethindene maleate was found in comparison to placebo [11].…”

Section: Discussionsupporting

confidence: 70%

Anti-Inflammatory Efficacy of Topical Preparations with 10% Hamamelis Distillate in a UV Erythema Test

Hughes-Formella

Filbry²,

Gassmueller³

et al. 2002

Skin Pharmacol Physiol

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In 40 volunteers the efficacy of three lotions with 10% hamamelis distillates from different suppliers, two vehicles, dimethindene maleate 0.1% gel, hydrocortisone 1% cream and hydrocortisone 0.25% lotion were investigated in a modified UV erythema test with three UV dosages (1.2, 1.4 and 1.7 MED). The test preparations were applied occlusively over a 48-hour period following irradiation. Chromametric measurement of redness and visual assessment were performed 24, 48 and 72 h after induction of erythema. The hydrocortisone formulations were most effective in erythema suppression. An anti- inflammatory effect was noted for all three hamamelis lotions as well as for the vehicles. A significantly greater suppression of erythema than seen with the vehicles was noted for one of the hamamelis lotions at 1.4 MED. The efficacy of the antihistamine dimethindene maleate did not surpass the hamamelis lotions or the vehicles. Even though the differences between the hamamelis lotions were slight, it was possible to make an objective selection of the best hamamelis distillate for aftersun purposes.

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Section: Discussionsupporting

confidence: 70%

Anti-Inflammatory Efficacy of Topical Preparations with 10% Hamamelis Distillate in a UV Erythema Test

Hughes-Formella

Filbry²,

Gassmueller³

et al. 2002

Skin Pharmacol Physiol

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“…A synergistic effect of oral NSAID and topical corticosteroids has been reported in the setting of a UV burn; 40 however, the need for the NSAID component to be administered early has limited their clinical application. Alternatives, such as oral terfenadine, 41 oral vitamin E, 42 oral betacarotene, 43 and oral and topical corticocorticoids 44–46 are not shown to be effective in treating phototherapy burns. Current treatment recommendations are largely supportive, and include the use of bland emollients, cool compresses and adequate pain control 47…”

Section: Discussionmentioning

confidence: 99%

Survey of phototherapy practice by dermatologists in Australia

2002

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A postal survey was sent to all dermatologists in Australia to determine current phototherapy practices. Questionnaires were returned by 158 (57%) of 277 dermatologists, of whom 112 (71%) provided phototherapy. Large variations existed in attitudes and practice, including indications, contraindications, dosage schedules, equipment maintenance, response to adverse events, and follow-up arrangements. Cumulative ultraviolet (UV) doses for psoralen and UVA (PUVA) were not calculated by 21%, while 30% did not calculate cumulative doses for UVB. Written informed consent was not obtained by 32%. Phototherapist dermatologists reported 25 patients developing melanoma following PUVA. Only 30% of Australian dermatologists organize regular follow up of patients after phototherapy. Australians have the highest rates of melanoma and non-melanoma skin cancers in the world, because of their ancestry and high solar exposure. This makes it inappropriate for Australian dermatologists to rely entirely on foreign safety data when assessing the risks and benefits of phototherapy in Australian patients. There is a need for standardized Australian guidelines that can be prospectively assessed to ensure phototherapy is used to maximize efficacy and minimize risks in Australian patients, given their unique ancestral mix and outdoor lifestyle.

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The Mode of Action of Cyclosporin

et al. 1990

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To try to explain the wide therapeutic range of cyclosporin A, we examined its effects on physiological functions of skin and responses to immunological and inflammatory stimuli during and before or after administration of 5 mg/kg/day of cyclosporin A in the treatment of various skin diseases.Pilocarpine-stimulated sweat rate (10 patients), sebum excretion rate (10), scalp hair growth rate (8) and epide' rmal proliferation in response to tape-stripping (7) were not affected by cyclosporin A; nail growth rate was unaltered in patients without psoriasis (12), but was significantly slowed by treatment in patients with psoriasis (7) who had abnormally rapid growth before treatment.Induction of cell-mediated sensitisation to 2,4-dinitrochlorobenzene (DNeB) was inhibited by cyclosporin A treatment (22 patients), but 7 patients sensitised to DNeB before cyclosporin treatment reacted normally to DNeB challenge during treatment. The immediate hypersensitivity response to intradermal house dust mite antigen was increased during treatment in 8 patients with atopy.Weal responses to histamine (9 patients) and compound 48/80 (12), the 24 hour erythemal response to ultraviolet B (UVB) irradiation (10) and the inflammatory response to topical leukotriene B4 (16) were not affected, but cyclosporin A produced a striking inhibition of anthralin inflammation (21).Since the methods we used will have detected all but minor changes, we conclude that cyclosporin A has no gross physiological effects on the skin and is not cytostatic; hypertrichosis must be due to a prolonged hair cycle. Secondly, cyclosporin A (a) impairs induction of cell-mediated sensitisation in doses which permit some continued expression, but (b) increases immediate hypersensitivity. Thirdly, cyclosporin A has no general anti-inflammatory effect, but we have found a novel and specific inhibitory effect on anthralin inflammation, the mechanism of which may underlie some of its therapeutic effects. The therapeutic effect of cyclosporin A may not be due solely to its immune effects, and other activities such as the anti-inflammatory effect we found need further exploration.

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A Quantitative Study of the Effect of Terfenadine on Cutaneous Erythema Induced by UVB and UVC Radiation

Cited by 8 publications

References 12 publications

Anti-Inflammatory Efficacy of Topical Preparations with 10% Hamamelis Distillate in a UV Erythema Test

Anti-Inflammatory Efficacy of Topical Preparations with 10% Hamamelis Distillate in a UV Erythema Test

Survey of phototherapy practice by dermatologists in Australia

The Mode of Action of Cyclosporin

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