A quartz crystal microbalance study of β-cyclodextrin self assembly on gold and complexation of immobilized β-cyclodextrin with adamantane derivatives

Poon, Kevin Hing-Nin; Cheng, Yu-Ling

doi:10.1007/s10847-007-9380-6

Cited by 7 publications

(6 citation statements)

References 64 publications

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“…Interaction of atrazine-based SAM with antiatrazine antibody was monitored by both ellipsometry and QCM measurements. QCM technique is well suited for the host–guest complex formation and antigen–antibody association , studies. For example, QCM technique confirmed suitability of alkanethiol SAMs for immobilization of biomolecules …”

Section: Results and Discussionmentioning

confidence: 99%

Atrazine-Based Self-Assembled Monolayers and Their Interaction with Anti-Atrazine Antibody: Building of an Immunosensor

et al. 2013

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As a part of our objective to build an immunosensor for the detection of the pesticide atrazine (ATZ) in environmental samples, we studied the self-assembling process of the disulfide derivative of the pesticide atrazine on a gold substrate. Atrazine-based self-assembled monolayers were characterized by ellipsometry, scanning tunneling microscopy, polarization-modulation infrared reflection-absorption spectroscopy (PM IRRAS), X-ray photoelectron spectroscopy and quartz crystal microbalance (QCM) measurements. Two different time constants for the adsorption process were observed, depending on the experimental method used. The QCM data reflect adsorption kinetics of the original disulfide compound, whereas ellipsometry and ex situ PM IRRAS refer to the formation of thiolate (ATZS) monolayers. In situ QCM data demonstrated the suitability of such monolayers for the detection of atrazine in aqueous samples. Exposure of the ATZS sensing surface to an anti-atrazine antibody (anti-ATZ IgG) resulted in complete coverage of the surface by antibody, whereas approximately half of the antibody molecules were displaced from the QCM sensor surface by further addition of atrazine into the solution.

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Section: Results and Discussionmentioning

confidence: 99%

Atrazine-Based Self-Assembled Monolayers and Their Interaction with Anti-Atrazine Antibody: Building of an Immunosensor

et al. 2013

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“…This approach has been chosen to be able to measure under the same buffer conditions as for the other samples. The equilibrium constant of the AD/CD complex is relatively high and lies in the order of 1–10 × 10 4 M –1 . − Therefore, dissociation in the time scale of the experiments is possible. However, the low solubility of AD-COOH under acidic conditions is supposed to have a significant influence in reducing such dissociation upon change of the solution conditions.…”

Section: Resultsmentioning

confidence: 99%

“…However, the low solubility of AD-COOH under acidic conditions is supposed to have a significant influence in reducing such dissociation upon change of the solution conditions. The influence of pH on the equilibrium constant of AD-COOH has been described previously …”

Section: Resultsmentioning

confidence: 99%

“…However, the presence of polymeric components, for example, in the form of adamante-poly(ethylene glycol), seems to have a strong effect on the equilibrium constant of the AD/CD inclusion complex. 69 In their presence, even irreversible association of AD/CD complexes has been observed with respect to rinsing with water. 73,74 The interpretation that the reduced adhesion for the CHI-AD polymer probe and CHI-CDblocked has to be attributed to the blocking or inaccessibility of the CD-moieties is further confirmed by the adhesion behavior of the same polymer probe with an unmodified chitosan layer.…”

Section: Force Profiles Of Chitosan-adamantane Probe Versusmentioning

confidence: 99%

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Probing Multivalent Host–Guest Interactions between Modified Polymer Layers by Direct Force Measurement

et al. 2011

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The adhesion behavior between modified polysaccharide layers capable of forming host-guest complexes has been determined by direct force measurements with the atomic force microscope (AFM). Polysaccharides bearing either host or guest moieties were obtained by derivatization of chitosan with pendant β-cyclodextrin (CD) and adamantane (AD) moieties, respectively. These modified polysaccharides were covalently immobilized either to flat surfaces or to AFM-probes. The number of interacting polymer segments has been reduced significantly by covalently immobilizing chitosan to an AFM-tip with small radius and measuring the forces between the protruding polymer segments and a chitosan layer immobilized to a flat surface. By this approach, it was possible to determine the interaction between polymer layers on the level of single polymer strands. To separate contributions to the adhesion due to the formation of host-guest complexes from unspecific interactions, we performed measurements between various combinations of chitosan derivatives. With the same polymer probe of adamantane-modified chitosan, the interaction against a number of different chitosan layers has been determined, including ones that are not able to form host-guest complexes, such as unmodified chitosan or β-cyclodextrin modified chitosan, which has been blocked previously by addition of adamantane. The resulting adhesion behavior has been analyzed in terms of the total work of adhesion, the number of rupture events, and the corresponding lengths of the polymer segments as well as rupture forces. A clear difference has been found for systems where the formation of host-guest complexes is possible in comparison to the absence of specific multivalent interaction between the polysaccharide layers. In particular, the work of adhesion is increasing up to an order of magnitude upon the formation of host-guest complexes between the chitosan layers.

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“…[21] Therefore, the success of this technique in terms of sensitivity and selectivity directly depends on the characteristics of chosen material used for preparation of QCM sensor. A variety of different coating elements including ionic liquids, [22] polymers, [23,24] nanoparticles, [25] nanocomposites, [26] and macromolecules [27][28][29] have been used for this purpose. Among the reported macrocyles, calixarenes, cup-shaped macrocyclic oligomers obtained by condensation of suitable functionalized phenols with formaldehyde, were generally preferred for preparation of Langmuir-Blodgett thin films due to their unique cavity structures and the presence of both hydrophobic and hydrophilic regions.…”

Section: Introductionmentioning

confidence: 99%

A Novel Calix[4]arene Thiourea Decorated with 2‐(2‐Aminophenyl)benzothiazole Moiety as Highly Selective Chemical Gas Sensor for Dichloromethane Vapor

et al. 2021

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A newly synthesized calix [4]arene thiourea derivative decorated with 2-(2-aminophenyl)benzothiazole unit is selected to take part important role in host-guest interactions of the macrocyclic molecules. p-tert-butylcalix [4]arene dithiourea (C[4]-DT) Langmuir-Blodgett (LB) thin films are prepared and characterized to develop a new sensing element for the detection of seven different organic vapors (dichloromethane, chloroform, acetone, benzene, carbon tetrachloride, toluene and m-xylene). The preparation of C[4]-DT-based thin films onto the different substrates was successfully and uniformly achieved with linear regressions of 0.9971 and 0.9954 for coating onto quartz glass and quartz crystal, respectively. The frequency shift (61.01 Hz) and the mass deposited onto quartz crystal (969.80 ng) were calculated for each layer. The swelling dynamics of C[4]-DT QCM chemical sensor was also illuminated by developing the early time Fick's diffusion equation. The sensing measurements can be concluded that owing to its high sensitivity (6.63 Hz/ ppm), fast response and low detection limit (0.45 ppm), this proposed C[4]-DT LB coated sensor is expected to be promising alternative chemical sensor for detection of DCM vapor.

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A quartz crystal microbalance study of β-cyclodextrin self assembly on gold and complexation of immobilized β-cyclodextrin with adamantane derivatives

Cited by 7 publications

References 64 publications

Atrazine-Based Self-Assembled Monolayers and Their Interaction with Anti-Atrazine Antibody: Building of an Immunosensor

Atrazine-Based Self-Assembled Monolayers and Their Interaction with Anti-Atrazine Antibody: Building of an Immunosensor

Probing Multivalent Host–Guest Interactions between Modified Polymer Layers by Direct Force Measurement

A Novel Calix[4]arene Thiourea Decorated with 2‐(2‐Aminophenyl)benzothiazole Moiety as Highly Selective Chemical Gas Sensor for Dichloromethane Vapor

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