A radio frequency device for measurement of minute dielectric property changes in microfluidic channels

Song, Chunrong; Wang, Pingshan

doi:10.1063/1.3072806

Cited by 61 publications

(49 citation statements)

References 12 publications

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“…Recent efforts on microwave characterization of single cells include resonator based circuits [5,6] and our previous work in [7,8]. Here we report our results in developing new microwave sensors, measuring single particles in liquids, and extracting the microwave permittivity of these particles with a new algorithm proposed in this work.…”

Section: Introductionmentioning

confidence: 93%

Measuring the microwave permittivity of single particles

Yang

Zhang

et al. 2013

2013 IEEE Topical Conference on Biomedical Wireless Technologies, Networks, and Sensing Systems

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We present a method to measure the permittivity of singles particles at microwave frequencies. Individual latex particles with diameters between 1 and 5 ȝm in de-ionized (DI) water are measured with a sensitive microwave sensor. An algorithm is developed to extract particle dielectric properties, which agree reasonably well with published results. The method is promising for single biological cell characterization at microwave frequencies.

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Section: Introductionmentioning

confidence: 93%

Measuring the microwave permittivity of single particles

Yang

Zhang

et al. 2013

2013 IEEE Topical Conference on Biomedical Wireless Technologies, Networks, and Sensing Systems

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“…Sensors based on measuring dielectric property changes [6][7][8], such as surface moisture sensors, have been demonstrated as well. Dielectric spectroscopy that measures dielectric properties and their changes has several advantages, including large volume manufacturing and easy integration with control circuitry [9].…”

Section: Introductionmentioning

confidence: 99%

A Radio Frequency Sensor For Measurement Of Small Dielectric Property Changes

Liu

Yue

2012

Journal of Electromagnetic Waves and Applications

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We propose a sensitive radio frequency (RF) sensor for the measurement of small dielectric property changes. Interference is used to cancel parasitic background signals to improve sensitivity. The device consists of two Wilkinson power dividers, a 180 degree reversephase and an in-phase CPW (coplanar waveguide)-slotline back-toback balun. The small dielectric property changes between de-ionize water and two sets of primary alcohol-water mixtures with different concentrations in terms of molar fractions are measured with clear sensing and identification. The sensor offers almost thirteen times greater sensitivity than conventional transmission lines. Experimental results also show that the lowest detection limit for the molarity of primary alcohol is about 0.25% across the sensitive sensor. Compared with microwave soil moisture sensors the proposed RF device is more sensitive.

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“…Considering the described pipe based microfluidic system, a much higher sensitivity is demanded, since the electric field needs to penetrate the wall thickness of the PTFE channel. Therefore, a differential method, presented in [3], was modified and put into operation, resulting in a phase sensitive biosensor working at 7 GHz. Measurements beyond 200 GHz were conducted with a continuous wave (CW) Terahertz spectrometer to investigate the possibilities and limitations of monitoring yeast cultivation in the sub-terahertz range.…”

Section: Introductionmentioning

confidence: 99%

Contactless Investigations of Yeast Cell Cultivation in the 7 GHz and 240 GHz Ranges

Wessel¹,

Schmalz²,

Gastrock³

et al. 2013

J. Phys.: Conf. Ser.

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Related contentHigh frequency fluidic and microfluidic sensors for contactless dielectric and in vitro cell culture measurement applications T Nacke, A Barthel, B P Cahill et al.-CMOS based sensor for dielectric spectroscopy of biological cell suspension S Guha, K Schmalz, C Meliani et al. The PTFE tube has an inner diameter of 0.5 mm resulting in a sample volume of 2 µl for 1 cm sample length. Two approaches (at frequencies around 7 GHz and 240 GHz) are presented and compared in terms of sensitivity and applicability. These frequency bands are particularly interesting to gain information on the permittivity of yeast cells in Glucose solution.Measurements from 240 GHz to 300 GHz were conducted with a continuous wave spectrometer from Toptica. At 7 GHz band, measurements have been performed using a ratrace based characterizing system realized on a printed circuit board. The conducted experiments demonstrate that by selecting the phase as characterization parameter, the presented contactless and label-free techniques are suitable for cell cultivation monitoring in a PTFE pipe based microfluidic system.

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A radio frequency device for measurement of minute dielectric property changes in microfluidic channels

Cited by 61 publications

References 12 publications

Measuring the microwave permittivity of single particles

Measuring the microwave permittivity of single particles

A Radio Frequency Sensor For Measurement Of Small Dielectric Property Changes

Contactless Investigations of Yeast Cell Cultivation in the 7 GHz and 240 GHz Ranges

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