A randomised double blind comparison of Syntometrine® and Syntocinon® in the management of the third stage of labour

Yuen, Pong Mo; Chan, Norman; Yim, So Fan; Chang, Allan

doi:10.1111/j.1471-0528.1995.tb11288.x

Cited by 59 publications

(37 citation statements)

References 8 publications

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“…6 In the present study mean duration of third stage of labour was 5.03±1.9 minutes in carboprost group. Our results are in accordance with the study of Yuen PH et al and Chua S et al 7,8 Bhide P et al studied the use of oxytocin, methylergometrine and carboprost during third stage of labour and found that the duration of 3 rd stage was 6 minutes 30 seconds, 5 minutes and 3 minutes 15 seconds respectively. 6 The results of our study do not match with those of the following studies.…”

Section: Discussionsupporting

confidence: 82%

Role of carboprost in prevention of postpartum hemorrhage

Lamba¹,

Joshi²,

Gupta³

2016

Int J Reprod Contracept Obstet Gynecol

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Section: Discussionsupporting

confidence: 82%

Role of carboprost in prevention of postpartum hemorrhage

Lamba¹,

Joshi²,

Gupta³

2016

Int J Reprod Contracept Obstet Gynecol

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“…Yuen et al. 26 reported a higher incidence of retained placenta associated with the use of syntometrine compared with intramuscular oxytocin, but a similar finding was not observed in our study. This might be related to the different methods of delivering placenta.…”

Section: Discussioncontrasting

confidence: 70%

Carbetocin versus syntometrine in prevention of post‐partum hemorrhage following vaginal delivery

Kampan

Zainuddin

Ghani

et al. 2009

J of Obstet and Gynaecol

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“…In a meta-analysis of 17 studies, while the rate of post-partum haemorrhage varied between 4% and 51% without uterotonic treatment, it was shown that the rate of post-partum haemorrhage regressed to the following values with prophylactic oxytocin infusion, misoprostol treatment and ergometrine treatment, respectively: 0-32%, 1-45% and 0-37%. In the same study, the blood loss occurring with the administration of prophylactic uterotonic treatment was compared [9,[17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33]. It was found that this was reduced by an average of 151-499 mL in the patients administered with oxytocin, 155-433 mL in the patients administered with misoprostol and 149-476 mL in the patients administered with ergometrine.…”

Section: Discussionmentioning

confidence: 99%

The Effect of the Combined Use of Methylergonovine and Oxytocin during Caesarean Section in the Prevention of Post‐partum Haemorrhage

Şentürk

Kağıtçı

Balık

et al. 2015

Basic Clin Pharma Tox

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We aimed to show to patients the benefit of post-partum haemorrhage prophylaxis treatment and the effectiveness as a uterotonic agent of the combined use of methylergonovine and oxytocin infusion in the prevention of haemorrhage during and after Caesarean section, by comparison with a control group which received oxytocin infusion only. Two groups of patients undergoing Caesarean section at the same clinic were included in the study. A combination of methylergonovine and oxytocin was administered to the first group during the intra-operative and post-operative periods. The second group did not receive methylergonovine and was administered only with oxytocin infusion in the intra-operative and post-operative periods. Pre-operative and post-operative haemogram readings were taken for all patients in each of the groups for comparison. No difference was found between the two groups with regard to mean ages and pre-operative haemogram values. The decrease in post-operative haemoglobin values for the group administered with methylergonovine maleate and oxytocin was found to be significantly greater than for the group administered with oxytocin only. Results indicated that prophylactic methylergonovine treatment was clearly successful for the patients and no adverse side effects were found. The routine use of methylergonovine and oxytocin infusion in combination during the intra-operative period of Caesarean section reduced the level of post-partum haemorrhage considerably. We believe that this procedure will also reduce the risk of uterine atony, but clearly, prospective studies will be necessary in future to confirm this assumption.In recent years, there has been a marked increase in the number of Caesarean sections carried out. This can be attributed largely to the rise in the rate of primary elective Caesarean section. In turn, this has led to a higher frequency of placenta previa, uterine atony and post-partum haemorrhage.The increased prevalence of post-partum haemorrhage across the world is of particular concern as it is widely recognized as a major contributor to maternal mortality. Studies have estimated that post-partum haemorrhage might account for as much as 30% of maternal mortality and its incidence all over the world ranged from 2 to 11% of all childbirths [1,2]. The frequency of post-partum haemorrhage was found to be higher in underdeveloped regions such as Africa, Asia and Latin America [3]. The currently accepted definition is to consider post-partum haemorrhage as blood loss of more than 500 mL whatever the type of delivery and severity as blood loss beyond 1000 mL [4]. The American College of Obstetricians and Gynaecologists adjudged that a decrease in haematocrit at a rate of 10% or more constituted post-partum haemorrhage [5].Although haemoglobin and haematocrit levels are valuable diagnostic tools in identifying haemorrhage, they can be misleading in the determination of acute bleeding. Therefore, follow-up of a patient's vital signs, together with checks of haemoglobin and haematocrit...

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A randomised double blind comparison of Syntometrine® and Syntocinon® in the management of the third stage of labour

Cited by 59 publications

References 8 publications

Role of carboprost in prevention of postpartum hemorrhage

Role of carboprost in prevention of postpartum hemorrhage

Carbetocin versus syntometrine in prevention of post‐partum hemorrhage following vaginal delivery

The Effect of the Combined Use of Methylergonovine and Oxytocin during Caesarean Section in the Prevention of Post‐partum Haemorrhage

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