A Randomized Controlled Trial for the Effectiveness of Aromatherapy in Decreasing Salivary Gland Damage following Radioactive Iodine Therapy for Differentiated Thyroid Cancer

Abstract

Objective. The aim of this study was to investigate effects of aromatherapy in decreasing salivary gland damage for patients undergoing radioactive iodine (RAI) therapy with differentiated thyroid cancer (DTC). Materials and Methods. The subjects were 71 patients with DTC. They were divided into aromatherapy group (group A, n = 35) and a control group (group B, n = 36). We blended 1.0 mL of lemon and 0.5 mL of ginger essential oils. The patients in the inhalation aromatherapy group inhaled this blend oil and those in the control group inhaled distilled water as placebo for 10 min during admission. We statistically compared salivary gland function before and after treatment between groups A and B. Results. In comparison with group B, the rate of change of the accumulation rate was significantly higher in the parotid glands and submandibular glands of group A (P < 0.05). In comparison with group B, a significant increase in rate of secretion change before and after treatment was noted in the bilateral parotid glands in group A (P < 0.05). Conclusion. Because an amelioration of salivary gland function was observed in the present study, our results suggest the efficacy of aromatherapy in the prevention of treatment-related salivary gland disorder. This trial is registered with UMIN Clinical Trial Registry: UMIN000013968.

The Impact of Herbal Infusion Consumption on Oxidative Stress and Cancer: The Good, the Bad, the Misunderstood

“…A randomized controlled trial suggested that aromatherapy (1 mL of lemon and 0.5 mL of ginger essential oil) has efficacy in preventing treatment-related salivary gland disorder [ 233 ]. Interestingly, a pilot study’s outcomes have shown that administering 2 g of ginger daily in patients with high risk for colorectal cancer may improve cell-cycle biomarkers in the normal-appearing colonic mucosa [ 234 ].…”

Recent advances in radiotherapy and its associated side effects in cancer—a review

“…Ginger and metoclopramide treatment are efficient to treat nausea and vomiting (Sontakke, Thawani, & Naik, 2003). Arogya-wardhani used to rescue abnormal liver functions (Antarkar, 1980) 4 Nonmelanoma Skin Cancer 45 Erythema, dermatitis, and atrophy Turmeric and sandalwood containing cream can treat dermatitis (Palatty et al, 2014) 5 Thyroid Cancer 60 Swelling or pain of salivary gland, headache, vertigo, insomnia, vocal cord paralysis, fatigue, general malaise, foreign body sensation, body numbness, and urinary tract infection Inhalation of blended 1 ml lemon and 0.5 mL of ginger essential oils showed significant improvement in salivary gland secretion (Nakayama, Okizaki, & Takahashi, 2016) 6 Colorectal Cancer 40-74 Nausea, bowel incontinence or stool leakage, fatigue, tiredness, rectal irritation, skin irritation, bladder irritation along with burning sensation or pain while urinating, diarrhea, blood in stool, vaginal irritation in women, and erection issues in men are seen abnormal chromosome with two centromere or translocated chromosomes, is an estimated risk of radiation dosage done by scoring chromosomal aberrations (Abe et al, 2016). In dicentric chromosomes, although the cells are unstable and cannot be passed through repeated mitotic division, the translocated chromosomes are stable.…”

Approach to Diagnosis of Salivary Gland Disease from Nuclear Medicine Images

“…Apitherapy using honey products is reportedly useful for preventing salivary gland disorders. Massage of the salivary glands and aroma therapy are also reported to relieve symptoms [18].…”