A randomized, investigator-blinded, controlled pilot study to evaluate the safety and efficacy of a poly-N-acetyl glucosamine–derived membrane material in patients with venous leg ulcers

Poly-N-Acetyl Glucosamine Fibers Activate Bone Regeneration in a Rabbit Femur Injury Model

“…A recently completed clinical trial in which patients with venous leg ulcers who were treated with a Food and Drug Administration-cleared wound healing product TalyMed ™ (consisting entirely of sNAG nanofibers) had more than 86% complete closure of wounds within 20 weeks, compared with 45% for patients treated with standard of care. 6 These findings support that pGlcNAc and sNAG nanofiber-based materials can be used not only to provide hemostasis but also to increase wound healing kinetics, thus providing a set of materials having dual utility for both hemostasis and treating wounds.…”

Poly-N-Acetyl Glucosamine (sNAG) Enhances Early Rotator Cuff Tendon Healing in a Rat Model

“…Previous pre-clinical and clinical studies have demonstrated improved wound healing with sNAG treatment, and Talymed® is currently indicated for management of wounds including diabetic ulcers, burns, abrasions and lacerations, and pressure wounds. 10,17 Our study, the first that investigates the effects of internal use of sNAG polymer after a musculoskeletal injury, suggests that this material also improves early tendon-to-bone healing in the rat rotator cuff. Unlike other forms of rotator cuff biological augmentation, no secondary procedures are needed to isolate cells or blood from the patient at the time of surgery.…”

“…13 Clinically, sNAG membranes have been shown to accelerate the rate of healing in venous leg ulcers, with an 86% success rate. 10 Animal studies utilizing this material for diabetic wound healing indicate enhanced cell migration, cell metabolic rates, vascularity within wound beds, and inflammatory cell recruitment. 17 These findings suggest that this material might also be helpful in tendon healing.…”

Successful treatment of two refractory venous stasis ulcers treated with a novel poly-N-acetyl glucosamine-derived membrane

“…We were compelled to try this new product based on a small randomised trial on the healing of venous stasis ulcers 4. The mechanism of action of poly-N-acetyl glucosamine-derived membran (pGlcNAc) nano-fibre-based membrane has been investigated invitro and invivo.…”