A randomized, multicentric, comparative evaluation of aceclofenac–paracetamol combination with aceclofenac alone in Indian patients with osteoarthritis flare-up

Pareek, Anil; Chandurkar, Nitin; Sharma, Vineet; Desai, Mohan M; Kini, Seema; Bartakke, Girish

doi:10.1517/14656560902781931

Cited by 13 publications

(6 citation statements)

References 19 publications

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“…How was found to be controversial 32,33 is indicated for the relief of pain and inflammation associated with rheumatoid arthritis, osteoarthritis, or Ankylosing spondylitis tolerability in patients but also compare it with diclofenac chronic pain 35 .…”

Section: Discussionmentioning

confidence: 99%

Comparative Study of Safety, Efficacy, and Tolerability of Aceclofenac Versus Diclofenac in Osteoarthritis Patients.

Kanaki¹,

Patil²,

Santoshkumar³

et al. 2013

jemds

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Section: Discussionmentioning

confidence: 99%

Comparative Study of Safety, Efficacy, and Tolerability of Aceclofenac Versus Diclofenac in Osteoarthritis Patients.

Kanaki¹,

Patil²,

Santoshkumar³

et al. 2013

jemds

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“…However, acetaminophen might be valuable for its advantageous synergistic effect when combined with other analgesics for pain relief. Pareek et al [ 41 ] in a randomised multicentre study demonstrated that the combination of aceclofenac and acetaminophen was superior over monotherapy in rapid pain relief for osteoarthritic flare-ups. However, Doherty et al [ 42 ] in a randomised double-blinded study concluded that while the combination of paracetamol and ibuprofen was superior for pain relief over paracetamol alone, it was not significantly superior over ibuprofen alone.…”

Section: Pharmacological Management In Osteoarthritismentioning

confidence: 99%

Conservative treatment of knee osteoarthritis: A review of the literature

Lim¹,

Al‐Dadah²

2022

WJO

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Knee osteoarthritis (KOA) is a common chronic debilitating disease with an estimated prevalence of 23.9% in the general adult population. The condition is characterised by joint pain, functional impairment and significant reduction in quality of life. Management for KOA can generally be divided into conservative (non-operative) and surgical (operative) measures. Conservative management broadly compromises pharmacological and non-pharmacological options and is conventionally the first line treatment to avoid or delay the need for surgical management. The aim of this study is to provide an overview of the current recommendations, efficacy and safety profile of different conservative treatments through a review of the literature.

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“…IL-1 beta and the tumor necrosis factor (TNF)-alpha are key cytokines in the catabolic process of cartilage degradation [13]. Inflammatory cytokines provide essential biochemical signals that stimulate chondrocytes to release cartilage-degrading enzymes [14].Prevalence of osteoarthritis increases with age and it affects 60% of men and 70% of women after the age of 65 [15].In our present study, out of total 80 cases, osteoarthritis of knee was affected in 37.5% of men and 62.5% of women. Mean and standard deviation of age, height, weight, BMI, systolic blood pressure and diastolic blood pressure of tramadol group patients (group A) were not statistically significant differences with aceclofenac group patients (group B).…”

Section: Discusionsmentioning

confidence: 99%

A Hospital Based Comparative Study of Tolerability and Efficacy of Tramadol Versus Aceclofenac on Patients With Osteoarthritis of Knee Joint.

Sultana

Sah

2019

IJMBS

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Objectives: This present study was done to compare the tolerability and efficacy of tramadol versus aceclofenac in terms of WOMAC Osteoarthritis Index and Visual Analogue Scale of patients with osteoarthritis of knee joint. Methods: A detail history, clinical examinations and relevant investigations were performed to all cases of osteoarthritis of knee joint. Group A patients were advised to receive tramadol 75 mg twice daily for 8 weeks, and group B patients were advised to receive aceclofenac 100 mg twice daily for 8 weeks. And we had evaluated the WOMAC Osteoarthritis Index and VAS score of first day and last day visit of patients with osteoarthritis of knee joint. Results: Data was analyzed by using SPSS (version 26) software. Paired sample statistical methods were used. Mean and standard deviation was observed and mean differences were compared. P value was taken less than or equal to 0.05 (p≤0.05) for significant differences. Conclusions: This present study concluded that the WOMAC Osteoarthritis Index score and VAS score of patients who had received aceclofenac medication had statistically significant differences as well as greater mean differences than patients who received tramadol. Hence, aceclofenac is effective drugs than tramadol in terms of efficacy and tolerability of patients with osteoarthritis of knee joint. Key words: Osteoarthritis of knee, WOMAC osteoarthritis index, Visual Analogue Scale.

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A randomized, multicentric, comparative evaluation of aceclofenac–paracetamol combination with aceclofenac alone in Indian patients with osteoarthritis flare-up

Cited by 13 publications

References 19 publications

Comparative Study of Safety, Efficacy, and Tolerability of Aceclofenac Versus Diclofenac in Osteoarthritis Patients.

Comparative Study of Safety, Efficacy, and Tolerability of Aceclofenac Versus Diclofenac in Osteoarthritis Patients.

Conservative treatment of knee osteoarthritis: A review of the literature

A Hospital Based Comparative Study of Tolerability and Efficacy of Tramadol Versus Aceclofenac on Patients With Osteoarthritis of Knee Joint.

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