A rapid and facile synthesis of new spiropyrimidines from 5-(2-arylethylidene-2-oxo)-1,3-dimethylpyrimidine-2,4,6-triones

Synthesis of symmetrical and unsymmetrical bis(pyrrolo[2,3-d]pyrimidinyl)methanes

“…Again, Nmethylated pyrrolo [2,3-d]pyrimidine-2,4-diones were more reactive than the partially unsubstituted pyrrolo [2,3-d] pyrimidine-2,4-diones. However, although the condensation of glyoxal [B] and 1,3-dimethylbarbituric acid 4 took place very easily, 24 the Michael addition of pyrrolo [2,3-d]pyrimidine-2,4diones 1 to the condensed product did not occur under our reaction conditions (Scheme 4). It might be because of the keto group which deactivates the nucleophilic addition.…”

Arylglyoxals in Synthesis of Heterocyclic Compounds

“…Gozalishvili et al described a similar reaction using 1,3-dimethylbarbituric acid 136 . The reaction was conducted by heating the solution of equimolar amounts of 136 , AGs, and 116 in MeOH in the presence of a catalytic amount of AcOH under reflux conditions for 25–40 min to produce imidazol-4-yl-pyrimidine-2,4,6-triones 137 in 62–87% yields (Scheme ).…”

N,N′-Dimethyl Urea

“…(D) The interaction of 1,3-dimethylbarbituric acid, glyoxals, and DMU in methanol with a catalytic amount of glacial acetic acid led to 5-(5-aryl-1,3-dimethyl-2-oxo-2,3-dihydro-1H-imidazol-4-yl)-1,3-dimethylpyrimidine-2,4,6-triones. 7 (E) N-methyl imines can be synthesized by the reaction of DMU and aldehydes in the presence of solid clay-montmorrilonite K10. 8 (F) The regioisomeric diene DMU 1,2-adducts A/B were synthesized by reacting isoprene with DMU using palladium(II) catalyst (O 2 /cat.)…”