A rapid profiling of gallotannins and flavonoids of the aqueous extract of Rhus coriaria L. by flow injection analysis with high-resolution mass spectrometry assisted with database searching

Regazzoni, Luca; Arlandini, E.; Garzon, Davide; Santagati, Natale Alfredo; Beretta, Giangiacomo; Facino, Roberto Maffei

doi:10.1016/j.jpba.2012.08.017

Cited by 60 publications

(42 citation statements)

References 39 publications

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“…Regazzoni et al. (2013) have reported the estimation of hydrolysable tannins of R. coriaria which are responsible for the antioxidant, antibacterial, anti‐inflammatory, antihypoglycemic, anti‐angiogenic, and anticancer activities. Ten gallotannins from mono‐ to deca‐galloyl glycosides of the class of hydrolysable tannins and a set of co‐extracted flavonoid derivatives including myricetin, quercetin‐3‐ O ‐rhamnoside, myricetin‐3‐ O ‐glucoside, myricetin‐3‐ O ‐glucuronide, and myricetin‐3‐ O ‐rhamnoglucoside were identified.…”

Section: Bioactivity Studiesmentioning

confidence: 99%

Phytochemical Diversity and Pharmacological Properties of Rhus coriaria

Elagbar

Shakya

Barhoumi

et al. 2020

Chemistry & Biodiversity

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Rhus coriaria L. (Anacardiaceae), sumac, is a common condiment, appetizer and souring agent in the Mediterranean region that has a long history in traditional medicine. R. coriaria has been prescribed for the treatment of many ailments including diarrhea, ulcer, hemorrhoids, hemorrhage, wound healing, hematemesis, and eye ailments like ophthalmia and conjunctivitis. The plant is also used as diuresis, antimicrobial, abortifacient and as a stomach tonic. Sumac is known to be rich in different classes of phytochemicals including tannins, polyphenols, flavonoids, organic acids and essential oils and continues to be a hot topic for extensive research work designed for revealing its phytochemical constituents and evaluating its bioactive properties. This review summarizes the recent phytochemical and diverse bioactivity studies on R. coriaria, especially those concerned with antitumor, antioxidant, hypoglycemic, antimicrobial, and anti-inflammatory studies.

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Section: Bioactivity Studiesmentioning

confidence: 99%

Phytochemical Diversity and Pharmacological Properties of Rhus coriaria

Elagbar

Shakya

Barhoumi

et al. 2020

Chemistry & Biodiversity

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“…GTs have exhibited diverse biological effects including antiinflammatory, anticancer, and antioxidant activities . GTs showed potent anticancer efficacy in vitro against various cancer cells, such as prostate, gastric, colon, and breast cancer with much low toxicity to normal cells.…”

Section: Anticancer Activities and Potential Mechanismsmentioning

confidence: 99%

Recent Advances in Anticancer Activities and Drug Delivery Systems of Tannins

Cai

Zhang

Chen

et al. 2016

Medicinal Research Reviews

105

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Tannins, polyphenols in medicinal plants, have been divided into two groups of hydrolysable and condensed tannins, including gallotannins, ellagitannins, and (-)-epigallocatechin-3-gallate (EGCG). Potent anticancer activities have been observed in tannins (especially EGCG) with multiple mechanisms, such as apoptosis, cell cycle arrest, and inhibition of invasion and metastases. Furthermore, the combinational effects of tannins and anticancer drugs have been demonstrated in this review, including chemoprotective, chemosensitive, and antagonizing effects accompanying with anticancer effect. However, the applications of tannins have been hindered due to their poor liposolubility, low bioavailability, off-taste, and shorter half-life time in human body, such as EGCG, gallic acid, and ellagic acid. To tackle these obstacles, novel drug delivery systems have been employed to deliver tannins with the aim of improving their applications, such as gelatin nanoparticles, micelles, nanogold, liposomes, and so on. In this review, the chemical characteristics, anticancer properties, and drug delivery systems of tannins were discussed with an attempt to provide a systemic reference to promote the development of tannins as anticancer agents.

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“…ICP-MS spectrometers allow the sensitive elemental determinations ( Figure 8) [103] or labeled molecules in cellular samples [104]. MS systems with ionization of organic compounds can be applied for very sensitive determinations of chemical residues [105], profiling of different groups of compounds [106], or replacing immunoassays in determination of different stimulants and their metabolites [107].…”

Section: Discussionmentioning

confidence: 99%

Flow Analysis as Advanced Branch of Flow Chemistry

Trojanowicz¹

2013

Mod Chem Appl

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The effectiveness of the carrying out chemical reactions, especially in terms of syntheses conducted in the laboratory or on a technological scale, is a primary target of the optimization of chemical conditions and physicochemical parameters of a given process. Since the publication of pioneering works in the beginning of 1970s, it is an increasingly accepted concept that carrying out chemical reactions in continuously flowing streams rather than in batch configuration has numerous advantages, hence flow chemistry can be at present considered as a separate and rapidly increasing area of modern chemistry. Four decades of the development of those methods resulted in thousands of original research works, numerous reported attractive technologies, and also in the presence of numerous specialized instruments on the market.

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A rapid profiling of gallotannins and flavonoids of the aqueous extract of Rhus coriaria L. by flow injection analysis with high-resolution mass spectrometry assisted with database searching

Cited by 60 publications

References 39 publications

Phytochemical Diversity and Pharmacological Properties of Rhus coriaria

Phytochemical Diversity and Pharmacological Properties of Rhus coriaria

Recent Advances in Anticancer Activities and Drug Delivery Systems of Tannins

Flow Analysis as Advanced Branch of Flow Chemistry

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