A Rare Case of Spontaneous Remission and Relapse of a Primary Central Nervous System Lymphoma

Ramos, R; Fernandes, João Soares; Almeida, Marta Carvalho de; Almeida, Rui

doi:10.20344/amp.10198

Cited by 2 publications

(1 citation statement)

References 5 publications

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“…It was a round, solid, unevenly enhanced, clear border, and the patient was a 6-year-old boy. [13][14][15][16] Therefore, he was diagnosed with medulloblastoma before surgery. 5 cases in this group are multiple lesions, and only 1 case has all the lesions located under the curtain, distributed in the cerebellar hemisphere, cerebellar vermiform part and midbrain, and strengthened in the form of patches at an early stage after enhancement.…”

Section: Discussionmentioning

confidence: 99%

Diagnosis and analysis of primary central nervous system lymphoma based on MRI segmentation algorithm

Liu

Liang

et al. 2021

Pak J Med Sci

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Objective: This paper summarizes the MRI imaging findings of primary central nervous system lymphoma (PCNSL) in the posterior cranial fossa to improve the accuracy of PCNSL diagnosis in the posterior cranial fossa. Methods: This study retrospectively analyzed the MRI imaging manifestations of 15 PCNSL posterior cranial fossa cases confirmed by puncture or surgical pathology from June 2017 to May 2018, including their occurrence sites, the number of lesions, MRI plain and enhanced manifestations, and diffusion-weighted imaging (DWI) and magnetic resonance spectroscopy. Imaging (MRS) performance. Results: A total of 15 cases were enrolled, including 10 cases of single lesion and five cases of multiple lesions. The total number of lesions was 25, which were in the cerebellar hemisphere and cerebellar vermis, midbrain, fourth ventricle, and pontine cerebellum. The lesions were round, irregular, nodular, patchy, with low or medium signals on T1WI, equal or slightly higher signals on T2WI, and enhanced with 25 meningiomas-like gray matter signals. All of them were significantly strengthened. “Acupoint sign” and “umbilical depression sign” were seen in eight lesions. There were 17 massive and nodular enhancements, four striped enhancements, three patchy enhancements, and one circular enhancement. five cases of DWI showed homogeneous high signal, two cases showed uneven high signal, and 3 cases showed medium signal. The ADC value of tumor parenchyma in 10 patients was (0.62±0.095)×10-3mm2/s. MRS examination showed obvious Lip peak in two cases. Conclusion: PCNSL in posterior cranial fossa has certain characteristics. DWI, ADC value and MRS are helpful to improve the correct diagnosis rate of PCNSL. doi: https://doi.org/10.12669/pjms.37.6-WIT.4843 How to cite this:Lu G, Li Y, Liang X, Zhao Z. Diagnosis and analysis of primary central nervous system lymphoma based on MRI segmentation algorithm. Pak J Med Sci. 2021;37(6):1585-1589. doi: https://doi.org/10.12669/pjms.37.6-WIT.4843 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Section: Discussionmentioning

confidence: 99%

Diagnosis and analysis of primary central nervous system lymphoma based on MRI segmentation algorithm

Liu

Liang

et al. 2021

Pak J Med Sci

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Spontaneous Remission and Concomitant Progression in a Patient with DLBCL

et al. 2020

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Diffuse large B-cell lymphoma (DLBCL) is the most common type of lymphoma. Although DLBCL can be cured in more than half of all patients, up to 50% of patients become refractory to initial treatment or relapse after complete remission. We present a case of complete spontaneous remission of some tumors and concomitant newly developed tumors observed in a patient with relapsed DLBCL. Spontaneous remission of lymphoma without treatment is a rare phenomenon and can occur at baseline as well as in relapsed DLBCL. However, most patients who initially experience spontaneous remission later develop relapse. Thus, careful follow-up is required, and fluorine-18-fluorodeoxyglucose (18F-FDG) positron emission tomography (PET)/computed tomography (CT) allows monitoring of multiple lesions.

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A Rare Case of Spontaneous Remission and Relapse of a Primary Central Nervous System Lymphoma

Cited by 2 publications

References 5 publications

Diagnosis and analysis of primary central nervous system lymphoma based on MRI segmentation algorithm

Diagnosis and analysis of primary central nervous system lymphoma based on MRI segmentation algorithm

Spontaneous Remission and Concomitant Progression in a Patient with DLBCL

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