A rare cause of miliary pattern and respiratory failure – Benign metastasizing leiomyoma

Grafino, Mónica; Ferreira, Leonardo; Telo, L.; Mira, Siraj A.; Alvoeiro, Magda; Bárbara, Cristina

doi:10.1016/j.rppnen.2016.03.014

Cited by 5 publications

(3 citation statements)

References 3 publications

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“…Moreover, pneumothorax and cysts may occur in PBML patients, who should be differentially diagnosed for lymphangioleiomyomatosis (LAM), as this disease has the clinical characteristics of recurrent pneumothorax and cysts[ 11 ]. Rarely, PBML can cause respiratory failure[ 12 ] and present as progressive pneumothorax[ 13 ]. In addition, BML can affect other organs and systems in PBML patients; therefore, other systems may manifest clinical symptoms, such as leg aches and paresthesia due to spinal BML[ 14 ].…”

Section: Discussionmentioning

confidence: 99%

Pulmonary benign metastasizing leiomyoma: A case report and review of the literature

Dai

Guo

Shen

et al. 2020

WJCC

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BACKGROUND Pulmonary benign metastatic leiomyoma (PBML), which is very rare, is a type of benign metastatic leiomyoma (BML). Here, we report a case of PBML, finally diagnosed through multidisciplinary team (MDT) discussions, and provide a literature review of the disease. CASE SUMMARY A 55-year old asymptomatic woman was found to have bilateral multiple lung nodules on a chest high-resolution computed tomography (HRCT) scan. Her medical history included total hysterectomy for uterine leiomyoma. The patient was diagnosed with PBML, on the basis of her clinical history, imaging manifestations, and computed tomography (CT)-guided percutaneous lung puncture biopsy, via MDT discussions. As the patient was asymptomatic, she received long-term monitoring without treatment. A follow-up of chest HRCT after 6 mo showed that the PBML lung nodules were stable and there was no progression. CONCLUSION For patients with a medical history of hysterectomy and uterine leiomyoma with lung nodules on chest CT, PBML should be considered during diagnosis based on the clinical history, imaging manifestations, CT-guided percutaneous lung puncture biopsy, and MDT discussions.

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Section: Discussionmentioning

confidence: 99%

Pulmonary benign metastasizing leiomyoma: A case report and review of the literature

Dai

Guo

Shen

et al. 2020

WJCC

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“…Mean time from primary surgery to BLM diagnosis is often longer with a median of 8.8 years and most of time diagnosis is only made after patients reporting pulmonary symptoms such as couch, dyspnea, chest pain, or even pneumothorax rather than routine imaging monitoring after BML diagnosis [18] . Rarely, PBML causes respiratory failure [41] .…”

Section: Ivl: Review Of Literaturementioning

confidence: 99%

Intravenous leiomyomatosis: Case series and review of the literature

Mathey

Huber

2021

International Journal of Surgery Case Reports

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Introduction Intravenous leiomyomatosis (ILV) is a rare pathology, part of leiomyoma beyond the uterus (LBU), characterized by benign smooth muscle cell tumor outside of the uterus and mainly affecting premenopausal woman with a medical history of leiomyoma or gynecologic surgical treatment. The treatment depends on the localization of the tumor, age of the patient, initial size, symptoms and the suitability for surgery but should always aims in toto surgical resection. Case presentation Retrospective case series and review of literature. Clinical discussion Symptoms presented by the patient were aspecific and only localized in the pelvic area. All cases were fortuitous histopathological diagnosis. No relapse was. Two out of 5 patients have pulmonary nodules, only one was biopsied and diagnosed with PBML (pulmonary benign metastasizing leiomyoma). Conclusion IVL and BML are rare disease that can co-exist. Because of tumoral hormonal receptors, hormonotherapy could be an optional treatment but to date no clear efficacy is demonstrated. In case of high recurrence risk such as voluminous initial mass, impairment of broad ligament, failure of total surgical resection, adjuvant hormonotherapy could be useful. Recurrence rate is about 16.6-30% and can occur even dozen years later and even after radical surgery, justifying a regular follow up.

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“…Lesions are usually slow-growing, although symptoms such as cough and chest pain are not rarely reported (28,29). At least one case of death from respiratory failure due to massive hilar metastases and a case of potentially fatal haemoptysis have been described (30,31).…”

Section: The Case Of Benign Metastasizing Leiomyoma (Bml)mentioning

confidence: 99%

Pulmonary metastasectomy in uterine malignancy: outcomes and prognostic factors

Rocco¹,

Nardini²,

Waller³

2017

J. Thorac. Dis.

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Metastatic uterine cancer is a form of systemic disease. As for other solid tumours, it is advocated by some authors that in selected patients, lung metastasectomy may play a role in long-term disease control. The practice of lung metastasectomy is however open to criticism as there is lack of convincing evidence, and over-encouraging outcomes may be attributed to intrinsic selection bias. The case of metastatic uterine tumours is reviewed in the light of the available literature, in order to identify common patterns and prognostic factors that may influence and determine an individualised and informed patient decision.

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A rare cause of miliary pattern and respiratory failure – Benign metastasizing leiomyoma

Cited by 5 publications

References 3 publications

Pulmonary benign metastasizing leiomyoma: A case report and review of the literature

Pulmonary benign metastasizing leiomyoma: A case report and review of the literature

Intravenous leiomyomatosis: Case series and review of the literature

Pulmonary metastasectomy in uterine malignancy: outcomes and prognostic factors

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