A rare coexistence of thyroid lymphoma with papillary thyroid carcinoma

Abstract

Diseases of the thyroid gland are frequently seen in general practice. Lymphoma of the thyroid is one of the rarest tumors. Its coexistence with papillary thyroid carcinoma is even rarer. Here, we present a 50-year-old female patient, who presented to our clinic with complaints of a rapidly growing lump on her neck, aphagia, and shortness of breath. A total thyroidectomy was performed. Histopathological analysis revealed the concomitant existence of papillary tumor. It should be noted that tumors with different histopathological behavior may rarely coexist with lymphoma in the thyroid gland. Masses growing rapidly in the thyroid shall suggest lymphoma.

Primary thyroid diffuse large B-cell lymphoma coexistent with papillary thyroid carcinoma: A case report

“…A previous study demonstrated that the presence of mediastinal lymph node involvement was the most important prognostic factor for PTL . As for PTC, the prognosis of occult papillary cancer with a diameter <1 cm is good and 10‐year survival rate is as high as 85% . According to that, as the diameter of our case's PTC was smaller than 1 cm, we classified it as a micro‐PTC.…”

“…Constituting nearly 80% of all thyroid cancer, PTC is the most common type of thyroid malignancy with the lowest level of malignancy. To our knowledge, the coexistence of PTL and PTC is very rare, and only several cases have been previously reported (Table ).…”

“…Prognosis of PTL depends on the spread of the disease and the grade of the tumor. In early diagnosed cases, 5‐year survival rate is about 80% if the tumor is limited to the thyroid, whereas the rate decreases to 35% if there is a lymphatic spread in the neck, and if a widespread retention exists, the rate even goes down to 5% . A previous study demonstrated that the presence of mediastinal lymph node involvement was the most important prognostic factor for PTL .…”

“…For PTC, surgical resection is the common treatment; although the therapeutic strategy is chosen mainly based on the subtype and stage of PTL. Currently, the surgery is not the conventional therapy for PTL, and it is only adopted to relief the compression of trachea and esophagus, and to obtain specimens for final diagnosis . It is notable that for patients who are diagnosed with the coexistence of PTL and PTC, total thyroid resection is not necessary, but the PTC‐affected lobe of the thyroid is suggested to be resected as complete as possible because the main treatment of PTC is surgical resection.…”

Rare Concurrence of Triple Primary Thyroid Cancer: A Patient of Papillary Carcinoma, Follicular Carcinoma, and Primary Lymphoma of the Thyroid

“…Some practitioners 7) have recommended that fine needle aspiration and adjuncts should be the initial tests that are used to di- The management of co-occurring cancers should be considered separately, and the patient's prognosis is probably dominantly affected by the cancer that has the worst prognosis. 3,[10][11][12][13][14] If there is insufficient response after 1 st line chemotherapy for primary thyroid lymphoma, each residual lesion should be biopsied to confirm its pathological type, since the response rate of R-CHOP chemotherapy to DLBL is excellent, over 80% in stage I. In cases that involve the simultaneous occurrence of multiple thyroid neoplasms, surgery can be considered as standard of care.…”