A Rare Condition Associated With Celiac Disease: Evans Syndrome

Abstract

Celiac disease (CD) is one of the most common chronic disorders in childhood. Autoimmune and nonautoimmune disorders including dermatitis herpetiformis, type 1 diabetes mellitus, and autoimmune thyroiditis can be encountered associated with CD. Common hematologic manifestations of CD include anemia owing to iron, folate, or vitamin B12 deficiency. We report a case with CD associated with Evans syndrome of whom to our knowledge, is the first child to be reported in the literature.

Immune Thrombocytopenic Purpure and Coeliac Disease

“…Similarly, coeliac disease (CD) is also an immune mediated enteropathy caused by permanent sensitivity to gluten in genetically susceptible individuals 3 . Co‐occurrence of CD and other autoimmune disorders such as idiopathic pulmonary haemosiderosis, autoimmune thyroiditis and Evans syndrome have been widely described in literature 4 . However, in child with ITP, co‐occurrence with CD has been rarely reported, underlying the importance of autoimmune phenomena in this disorder.…”

Severe Evans syndrome with multi‐system involvement is a distinct immunodeficiency disorder

“…Unique clinical features include severe hepatic dysfunction, myasthenia gravis, hypothyroidism, dermatitis, and renal disease. There are rare reports of Evans syndrome patients having isolated skin, gastrointestinal or renal manifestations, autoimmune hepatitis or neurological symptoms 6–10. In contrast, the association between Evans syndrome and thyroid abnormalities is more common 11.…”

Celiacs Disease Is Not a Major Risk Factor for the Development of Childhood Idiopathic Thrombocytopenic Purpura

“…1 Celiacs disease (CD) is an autoimmune disorder characterized by an immune response and lack of tolerance to ingested gluten. 2,3 Several autoimmune diseases are associated with CD.…”