A ratiometric time-gated luminescence probe for hydrogen sulfide based on copper(II)-coupled lanthanide complexes

Tang, Zhixin; Song, Bo; Ma, Hua; Shi, Yuanyuan; Yuan, Jingli

doi:10.1016/j.aca.2018.10.048

Cited by 34 publications

(28 citation statements)

References 44 publications

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“…Recently, we demonstrated that the mixture of luminescent Eu 3+ and Tb 3+ complexes chelated by the same ligand could be used as luminophores for the design of RTGL probes. By incorporating different analyte-responsive moieties into the terpyridine polyacid ligands of Eu 3+ /Tb 3+ complexes, the RTGL probes for biothiols, hydrogen sulfide, and carbon monoxide have been successfully developed. In this work, by aiming at the development of RTGL probes for O 2 •– in ER of live cells, a lanthanide complex-based ER-targetable luminescence probe, namely, ER-NFTTA-Eu 3+ /Tb 3+ , was designed and synthesized for the monitoring of drug-induced AKI.…”

Section: Resultsmentioning

confidence: 99%

Precise Monitoring of Drug-Induced Kidney Injury Using an Endoplasmic Reticulum-Targetable Ratiometric Time-Gated Luminescence Probe for Superoxide Anions

et al. 2019

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Drug-induced acute kidney injury (AKI), caused by renal drug metabolism, has been considered to be a major barrier in drug development and clinical treatment. Among various drugs, anticancer drugs, cisplatin, and aminoglycoside antibiotic gentamicin, are known to be able to induce excessive or unfolded accumulation of proteins in the endoplasmic reticulum (ER) of cells, leading to ER stress. Meanwhile, reactive oxygen species (ROS) are formed, and superoxide anion (O2 •–), the first produced ROS, is a key species to induce the AKI. Due to the lack of appropriate tools, the early diagnosis of AKI induced by cisplatin, gentamicin, or other drugs is still a crucial challenge. Herein, we report a lanthanide complex-based ER-targetable luminescence probe for O2 •–, ER-(4'-trifluoromethanesulfonyloxy-2,2':6',2''-terpyridine-6,6''-diyl)bis(methylenenitrilo)tetrakis (aceticacid) (NFTTA)-Eu3+/Tb3+, for the sensitive monitoring of drug-induced AKI via mapping the generation of O2 •– in live cells and laboratory animals. Using this probe coupled with the ratiometric time-gated luminescence (RTGL) imaging technique, the changes of O2 •– level in the ER of live cells induced by different stimuli were precisely monitored. More importantly, the substantial increases in O2 •– levels were observed in the cisplatin- and gentamicin-induced kidney injury of mice. In addition, the protective effects of l-carnitine (LC) and epigallocatechin-3-gallate (EGCG) against cisplatin- and gentamicin-induced nephrotoxicity were visualized and elucidated for the first time. The results demonstrated the potential of ER-NFTTA-Eu3+/Tb3+ for examining and monitoring O2 •– in drug-induced AKI and for providing a diagnosis and treatment of nephrotoxicity diseases.

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Section: Resultsmentioning

confidence: 99%

Precise Monitoring of Drug-Induced Kidney Injury Using an Endoplasmic Reticulum-Targetable Ratiometric Time-Gated Luminescence Probe for Superoxide Anions

et al. 2019

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“…Yuan et al later demonstrated 50-51 (Fig. 30) could be efficiently used as a H2S detector, by using the same mechanism [168]. Coordination of copper to the bis[(2-picolyl)amine] unit induces a quenching of the Eu 3+ luminescence.…”

Section: Detection Via Copper Coordinationmentioning

confidence: 94%

Lanthanide complexes as redox and ROS/RNS probes: A new paradigm that makes use of redox-reactive and redox non-innocent ligands

Leguerrier

Barré

Molloy

et al. 2021

Coordination Chemistry Reviews

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HAL is a multi-disciplinary open access archive for the deposit and dissemination of scientific research documents, whether they are published or not. The documents may come from teaching and research institutions in France or abroad, or from public or private research centers. L'archive ouverte pluridisciplinaire HAL, est destinée au dépôt et à la diffusion de documents scientifiques de niveau recherche, publiés ou non, émanant des établissements d'enseignement et de recherche français ou étrangers, des laboratoires publics ou privés.

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“…Based on the CuS precipitation strategy, Yuan designed a novel Cu 2+ -coupled lanthanide complex (probe 70) 89 for the ratiometric time-gated luminescence detection of H 2 S in vitro and in vivo. By functionalizing triarylboron with cyclen and diphenylamine, Yang et al constructed a two-photon uorescent probe for sensing H 2 S (probe 71).…”

Section: Cus Precipitationmentioning

confidence: 99%

Small-molecule fluorescent probes for imaging gaseous signaling molecules: current progress and future implications

et al. 2020

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A ratiometric time-gated luminescence probe for hydrogen sulfide based on copper(II)-coupled lanthanide complexes

Cited by 34 publications

References 44 publications

Precise Monitoring of Drug-Induced Kidney Injury Using an Endoplasmic Reticulum-Targetable Ratiometric Time-Gated Luminescence Probe for Superoxide Anions

Precise Monitoring of Drug-Induced Kidney Injury Using an Endoplasmic Reticulum-Targetable Ratiometric Time-Gated Luminescence Probe for Superoxide Anions

Lanthanide complexes as redox and ROS/RNS probes: A new paradigm that makes use of redox-reactive and redox non-innocent ligands

Small-molecule fluorescent probes for imaging gaseous signaling molecules: current progress and future implications

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