A reagentless and disposable electronic genosensor: from multiplexed analysis to molecular logic gates

Xiang, Yun; Qian, Xiaoqing; Chen, Ying; Zhang, Yuyong; Chai, Yaqin; Yuan, Ruo

doi:10.1039/c0cc04350h

Cited by 47 publications

(25 citation statements)

References 31 publications

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“…334 DNA sensors based on hairpin structures equipped with redox-tags and immobilized on electrode surfaces have also been reported. 335,336 Another approach to design DNA-based logic gates is to use DNA molecules with biocatalytic properties mimicking enzyme functions, so-called DNAzymes. 337 Willner et al have designed an entire DNA computing circuit based on the modular coupling of DNAzyme subunits.…”

Section: Information Storage and Processingmentioning

confidence: 99%

Supramolecular self-assemblies as functional nanomaterials

et al. 2013

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In this review, we survey the diversity of structures and functions which are encountered in advanced self-assembled nanomaterials. We highlight their flourishing implementations in three active domains of applications: biomedical sciences, information technologies, and environmental sciences. Our main objective is to provide the reader with a concise and straightforward entry to this broad field by selecting the most recent and important research articles, supported by some more comprehensive reviews to introduce each topic. Overall, this compilation illustrates how, based on the rules of supramolecular chemistry, the bottom-up approach to design functional objects at the nanoscale is currently producing highly sophisticated materials oriented towards a growing number of applications with high societal impact.

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Section: Information Storage and Processingmentioning

confidence: 99%

Supramolecular self-assemblies as functional nanomaterials

et al. 2013

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“…electrode surface. Despite this and other recent advances, sensors that employ only one signaling mechanism can still be limiting [78,82,83]. For this reason, it is noteworthy that the use of multiple redox labels (e.g., Fc and MB), as developed by Lai et al [84], is capable of providing additional electrochemical information at various redox potentials ( Fig.…”

Section: Samsmentioning

confidence: 99%

Stimuli‐Responsive Surfaces in Biomedical Applications

Pranzetti¹,

Preece²,

Mendes³

2013

Intelligent Stimuli‐Responsive Materials

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Nature provides mechanisms that are able to dynamically control specific and nonspecific interactions between cells and biological surfaces [1,2]. Scientists have long tried to reproduce these dynamic biological events and have recently made an important step in that direction by creating artificial stimuli-responsive surfaces [3][4][5][6][7]. These smart substrates present modulatory surface properties that are able to respond to external chemical/biochemical [8][9][10][11][12], thermal [13][14][15], electrical [16][17][18][19][20], and optical stimuli [21][22][23][24][25][26][27][28][29][30][31]. Due to their dynamic nature such substrates are very appealing for applications in the biomedical field [32]. Progress to date has led to control over biomolecule activity [33] and immobilization of a diverse array of proteins, including enzymes [34] and antibodies [35]. These prior achievements have encouraged researchers to take the challenge of using dynamic surfaces to modulate larger and more complex systems, such as bacteria [36] and mammalian cells [37].Achieving control over surface properties could provide new insights in the understanding of cell behavior and can offer distinct benefits with regard to the development of medical devices. For instance, the modulation of cell attachment and detachment could lead to the prevention of unwanted bacteria fouling on implants, reducing the risk of infections and rejection [38][39][40][41][42]. Furthermore, dynamic surfaces able to present on demand regulatory signals to a cell could provide unprecedented opportunities in studies of cell responses in real-time. Cells in tissues adhere to and interact with their extracellular environment via specialized cell-cell and cell-extracellular

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“…They have been widely applied in the detection of meaningful analytes, such as thrombin [8][9][10][11], cocaine [12][13][14][15][16], adenosine triphosphate [10,17,18], lysozyme [19,20], and platelet-derived growth factor [21,22]. Many of the E-AB biosensors are based on the single signaling response [9,13,18,23], while some papers focus on the dual-signaling E-AB sensors due to the advantages of high sensitivity and low detection limit [24][25][26][27].…”

Section: Introductionmentioning

confidence: 99%

“…Usually, the construction of dual-signaling E-AB sensors is based on two partially or completely complementary DNA chains, each of which is tagged with redox species at one end of the chain, and the targets chosen for detection typically have only one aptamer-binding site [24][25][26]. However, many targets, such as thrombin [28,29], platelet-derived growth factor [30,31], prostate specific antigen [32], and vascular endothelial growth factors [33] and MUC1 protein [34], have more than one sites to bind their aptamers or antibodies to form a sandwich structure, which has an obviously better anti-interference ability than the simple biosensing structure [35].…”

Section: Introductionmentioning

confidence: 99%

A ratiometric electrochemical aptasensor for sensitive detection of protein based on aptamer–target–aptamer sandwich structure

Zhou

et al. 2014

Journal of Electroanalytical Chemistry

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A reagentless and disposable electronic genosensor: from multiplexed analysis to molecular logic gates

Cited by 47 publications

References 31 publications

Supramolecular self-assemblies as functional nanomaterials

Supramolecular self-assemblies as functional nanomaterials

Stimuli‐Responsive Surfaces in Biomedical Applications

A ratiometric electrochemical aptasensor for sensitive detection of protein based on aptamer–target–aptamer sandwich structure

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