A real reason for patients with pseudobulbar affect to smile

Rosen, Howard J.; Cummings, Jeffrey L.

doi:10.1002/ana.21056

Cited by 38 publications

(38 citation statements)

References 47 publications

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“…In our sample the LEC factor was strongly related to BI, and not to the neuroanatomical variables taken into account; thus, it is conceivable that the clinical manifestation of a reduced emotional control, expressing as catastrophic reaction (i.e., a progressive lost of control with prominent emotive manifestation when patients are facing their difficulties) and/or uncontrolled emotional outbursts, could also derive from the perception of functional deficits. Furthermore, in our sample the emotional discharge was more often related to a distressing situation (as in most cases it consisted of outburst of crying) than usually reported in the definition of emotionalism or pseudobulbar affect [38]. These data lead to the hypothesis that these symptoms may represent an easily elicited loss of emotional control in patients with an underlying depression, more than a manifestation of pseudobulbar affect interpreted as a pure "liberation" phenomenon.…”

Section: Psychiatric Historymentioning

confidence: 53%

“…This result could be quite surprising, since the abnormalities of the emotional regulation are often seen as a direct consequence of the anatomical damage [38]. In previous studies, catastrophic reaction in post-stroke subjects has been linked to a higher frequency of anterior and subcortical lesions [43]; on the other hand, lesion studies have reported various injury sites in connection to hyperemotionalism, even in this case with a predominance of lesions of frontal and subcortical structures [24,38]. Nevertheless, a specific investigation of such phenomena in a selected PSD sample has not been conducted.…”

Section: Psychiatric Historymentioning

confidence: 99%

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Post-Stroke Depression: Main Phenomenological Clusters and their Relationships with Clinical Measures

Quaranta

Marra

Gainotti

2012

Behavioural Neurology

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Abstract. Objectives:To investigate the principal psychopathological dimensions of post-stroke depression (PSD) through the assessment of the factorial structure of the Post-Stroke Depression Rating Scale (PSDRS). Methods: We enrolled ninety-eight subjects with PSD, who underwent the PSDRS, MMSE and Barthel Index. Information about demographic, clinical, and neuroanatomical factors was collected.Results: The factor analysis extracted three factors accounting for 63.4% of the total variance, and identified as: 1) "Depressive and Anxious Symptoms" (DAS); 2) "Lack of Emotional Control" (LEC); 3) "Reduced Motivation" (RM). On multivariate statistics, DAS severity was predicted by previous history of mood disorders and Barthel Index; LEC severity was predicted by Barthel Index; RM severity was predicted by age. Conclusions: The PSDRS displayed a reliable factor structure that agreed with previous interpretation of PSD. In particular, core depressive symptoms seem to be related to premorbid personality and functional status, whereas apathy/anhedonia may be connected to brain aging.

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Section: Psychiatric Historymentioning

confidence: 53%

Section: Psychiatric Historymentioning

confidence: 99%

Post-Stroke Depression: Main Phenomenological Clusters and their Relationships with Clinical Measures

Quaranta

Marra

Gainotti

2012

Behavioural Neurology

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“…Pathological laughing and crying should include all other disorders of laughing and crying observed in stroke patients. The designation ‘emotional incontinence’ is distasteful because of its similarity with sphincter incontinence [57]. The current name ‘involuntary emotional expression disorder’ [57] puts the emphasis on the core components of the disorder: the lack of voluntary control and the fact that only the expression of emotion is involved.…”

Section: Disturbances Of Emotional Expression Controlmentioning

confidence: 99%

Poststroke Emotional and Behavior Impairment: A Narrative Review

Ferro

Caeiro

Santos³

2009

Cerebrovasc Dis

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Emotional and behavioral disturbances are a frequent complication in stroke survivors. They are underdiagnosed, have a high impact on quality of life and are often a precipitant of institutionalization. For the caregivers of stroke survivors, these disturbances are a main cause of exhaustion. Health professionals have an insufficient training in their diagnosis and management which demands qualified skills and dedication of a multiprofessional team. In this article, we update some of the most common or relevant poststroke emotional and behavioral disturbances, including poststroke mania and poststroke depression, poststroke anxiety disorders, posttraumatic stress disorder, personality changes with focus on apathy and disturbances of emotional expression control. Significant advances in the management of poststroke emotional and behavioral disturbances will need the use of comparable instruments and methods and multicenter collaboration.

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“…The treatment of these symptoms improves significantly the quality of life of patient with ALS. [23][24][25] …”

Section: Als Managementmentioning

confidence: 99%

Epidemiology and Clinical Description of Amyotrophic Lateral Sclerosis in Low Income Setting: A Syndrome with Short Survival

Assogba¹,

Brah²,

Kombaté³

et al. 2015

AJPN

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Abstract:Background: Amyotrophic lateral sclerosis (ALS) is a degenerative motor neuron disease. It evolves to loss of autonomy and death. Objective: To describe the cases of ALS clinically definite observed in hospital field. Patients and methods: The retrospective study has covered a period of 10 years (2003)(2004)(2005)(2006)(2007)(2008)(2009)(2010)(2011)(2012)) and a total of 10,128 patient's files were analyzed. The neurology department of our level 3 hospital has located the current study. Six patients with no particular medical history have been reported. The inclusion patients are cases where the diagnosis of ALS was clinically definite according to the modified El Escorial classification. About 978 of likely, possible and probable cases of ALS were not included. Results: The mean age was 49 years (24 and 67), all males, with a frequency of 0.59 ‰ and an incidence rate of 0.6 cases per year. The clinical signs were marked by the pyramidal syndrome and peripheral neuropathic motor syndrome. MRI or CT scan signs were marked by the bulbar light atrophy. EMG had shown spontaneous activities with reinnervation signs. The histology exam has found neurogenic fascicular atrophy. The average duration of progression of the disease from the diagnostic to death was 17.6 months (6 to 36). The median of survival all cases combined was 42 weeks. Symptomatic treatment was associated to rehabilitation. Riluzole has been established despite its high cost, but without success. Conclusion: This observation highlighted the major difficulties encountered in the management of ALS and its increasing frequency in south Saharan Africa.

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A real reason for patients with pseudobulbar affect to smile

Cited by 38 publications

References 47 publications

Post-Stroke Depression: Main Phenomenological Clusters and their Relationships with Clinical Measures

Post-Stroke Depression: Main Phenomenological Clusters and their Relationships with Clinical Measures

Poststroke Emotional and Behavior Impairment: A Narrative Review

Epidemiology and Clinical Description of Amyotrophic Lateral Sclerosis in Low Income Setting: A Syndrome with Short Survival

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