A review: Gelatine as a bioadhesive material for medical and pharmaceutical applications

Ahmady, Amina; Samah, Nor Hayati Abu

doi:10.1016/j.ijpharm.2021.121037

Cited by 89 publications

(44 citation statements)

References 168 publications

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“…Gelatin is a natural polymer that is biocompatible, biodegradable, adhesive, non-toxic, and affordable. Because of these properties, gelatin is used in the pharmaceutical and biomedical fields for drug delivery and tissue engineering [10]. Gelatin is often blended with other polymers to obtain better material properties such as mechanical behavior and printability.…”

Section: Introductionmentioning

confidence: 99%

3D Printed Buccal Films for Prolonged-Release of Propranolol Hydrochloride: Development, Characterization and Bioavailability Prediction

et al. 2021

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Gelatin-polyvinylpyrrolidone (PVP) and gelatin-poly(vinyl alcohol) (PVA) mucoadhesive buccal films loaded with propranolol hydrochloride (PRH) were prepared by semi-solid extrusion 3D printing. The aim of this study was to evaluate the effects of the synthetic polymers PVP and PVA on thermal and mechanical properties and drug release profiles of gelatin-based films. The Fourier-transform infrared spectroscopy showed that hydrogen bonding between gelatin and PVP formed during printing. In the other blend, neither the esterification of PVA nor gelatin occurred. Differential scanning calorimetry revealed the presence of partial helical structures. In line with these results, the mechanical properties and drug release profiles were different for each blend. Formulation with gelatin-PVP and PRH showed higher tensile strength, hardness, and adhesive strength but slower drug release than formulation with gelatin-PVA and PRH. The in silico population simulations indicated increased drug bioavailability and decreased inter-individual variations in the resulting pharmacokinetic profiles compared to immediate-release tablets. Moreover, the simulation results suggested that reduced PRH daily dosing can be achieved with prolonged-release buccal films, which improves patient compliance.

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Section: Introductionmentioning

confidence: 99%

3D Printed Buccal Films for Prolonged-Release of Propranolol Hydrochloride: Development, Characterization and Bioavailability Prediction

et al. 2021

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“…The molecular structure of gelatin contains many parts that form hydrogen bonds, such as carboxyl (-COOH), amine (-NH 2 ) and hydroxyl (-OH), so it is an excellent natural material. [33][34][35] Since many factors are involved in the process of cartilage repair, different drugs can positively affect cartilage repair in different ways during treatment. Among them, inhibiting the inammatory response in cartilage defects and promoting the transformation of stem cells into chondrocytes have been proved to be two important ways.…”

Section: Introductionmentioning

confidence: 99%

Preparation and characterization of a novel drug-loaded Bi-layer scaffold for cartilage regeneration

Yue

Lei

et al. 2022

RSC Adv.

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“…Gelatin is also extensively implied in many mucoadhesion systems but under the more general protein/ peptide systems. [11] Inspection of Table 1indicates that polyethylene glycol (PEG) is extensively used in the synthesis of mucin-mimic polymers. The process is generally known as PEGylation of polymers.…”

Section: Mucoadhesive Tissue-polymer Interfacesmentioning

confidence: 99%

“…Gelatin is also extensively implied in many mucoadhesion systems but under the more general protein/peptide systems. [ 11 ]…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in Mucoadhesive Interface Materials, Mucoadhesion Characterization, and Technologies

Bayer

2022

Adv Materials Inter

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Mucoadhesion is an extremely important field of adhesion science and the comprehensive understanding and modulation of mucoadhesion can lead to lifesaving materials and technologies. For instance, deadly cases of COVID‐19 (SARS‐CoV‐2) cytokine storm are associated with viral adhesion and overproduction of mucus, which obstructs the airways. Mucin is the key polymeric compound that is known as a family of high molecular weight, heavily glycosylated proteins in epithelial tissues. Mucoadhesion can occur in many different ways such as receptor specific and charge interactions, covalent or noncovalent bonds. New mucin‐mimic polymers that replicate its beneficial traits can prevent biofilm formation and biofouling not only in biotechnology but also in membrane technologies. This review addresses the latest understandings related to mucin's role in wet adhesion considering different physiological conditions and shows how this translates into interfacial polymer adhesion. Advances in mucoadhesion measurement techniques including the rheological aspects of polymer–mucin adhesive interactions are presented. Specific mucoadhesive systems are discussed such as hydrogel mucoadhesion, catechol/dopamine functionalization, and polymeric nanoparticles. This overview may expand the current understanding of mucoadhesion between soft materials but also contributes to elastocapillary phenomena in soft materials design and applications such as new membranes, drugs, pharmaceutical devices, and lubricated surfaces.

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A review: Gelatine as a bioadhesive material for medical and pharmaceutical applications

Cited by 89 publications

References 168 publications

3D Printed Buccal Films for Prolonged-Release of Propranolol Hydrochloride: Development, Characterization and Bioavailability Prediction

3D Printed Buccal Films for Prolonged-Release of Propranolol Hydrochloride: Development, Characterization and Bioavailability Prediction

Preparation and characterization of a novel drug-loaded Bi-layer scaffold for cartilage regeneration

Recent Advances in Mucoadhesive Interface Materials, Mucoadhesion Characterization, and Technologies

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