A Review of Aceclofenac: Analgesic and Anti-Inflammatory Effects on Musculoskeletal Disorders

Abstract

Aceclofenac is an oral non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory and analgesic properties. Although there are some differences in the authorized indications between countries, aceclofenac is mainly recommended for the treatment of inflammatory and painful processes, such as low back pain (LBP), scapulohumeral periarthritis, extraarticular rheumatism, odontalgia, and osteoarthritis (OA), rheumatoid arthritis (RA), and ankylosing spondylitis (AS). The analgesic properties and tolerability profile of aceclofenac in musculoskeletal disorders are reviewed, focusing on relevant and recent studies. The efficacy and safety comparison of aceclofenac with other analgesics and anti-inflammatory agents in OA, AS, RA, and LBP is described. Relevant studies were identified following a literature search of PubMed using the terms “aceclofenac” and “clinical trials” published from 1 Jan 1992 to 1 Jan 2020. Aceclofenac is at least as effective as other NSAIDs in reducing pain and/or improving functional capacity in chronic pain conditions (OA, AS, RA, and LBP). It is generally well tolerated and appears to have a more favorable GI profile than other NSAIDs. Thus, current evidence indicates that aceclofenac is a useful option for the management of pain and inflammation across a wide range of painful conditions.

Analgesics in rheumatic diseases – a necessary component of therapy aimed at improving the quality of life

“…Одним из наиболее сбалансированных по соотношению выраженности лечебного действия, относительно низкого риска развития серьезных НР и общей переносимости НПВП представляется ацеклофенак [41]. Он широко используется во многих странах мира, хорошо известен и востребован российскими врачами, занимающимися ведением больных со скелетно-мышечной патологией.…”

Effect of Andrographis paniculata extract and Andrographolide on the pharmacokinetics of Aceclofenac and Celecoxib in rats

“…Aceclofenac is a phenylacetic acid derivative nonsteroidal anti-inflammatory drug (NSAID). It is a potent inhibitor of cyclooxygenase and possesses anti-inflammatory and analgesic properties [ 1 ]. Celecoxib is an effective COX 2 inhibitor NSAID and act as analgesic.…”

Pathway to Construct α-Acyloxy Esters by B(C6F5)3-Catalyzed O–H Insertion of Carboxylic Acids with Sulfoxonium Ylides

“…For instance, Sheha reported a kind of brain site-specific delivery NAP prodrug (Scheme a), which is a promising candidate for safe and chronic nonsteroidal anti-inflammatory drug (NSAID) in the treatment of neurodegenerative diseases . Aceclofenac, a popular analgesic and NSAID, is used for prolonged treatment of musculoskeletal disorders . But it has several limitations such as poor water solubility, low oral bioavailability, and gastric toxicity.…”

“…3 Aceclofenac, a popular analgesic and NSAID, is used for prolonged treatment of musculoskeletal disorders. 4 But it has several limitations such as poor water solubility, low oral bioavailability, and gastric toxicity. To overcome these drawbacks, Maria Grazia Rimoli group designed and synthesized an orally administrable prodrug ACEgal (Scheme 1a).…”