A Review of antihyperlipidemic effect of synthetic phenolic compounds

Nawaz, Shah; Shareef, Muhammad; Shahid, Hina; Mushtaq, Misbah; Sarfraz, Maliha

doi:10.26480/msm.01.2017.22.26

Cited by 11 publications

(11 citation statements)

References 28 publications

(30 reference statements)

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“…Alloxan causes time and concentration dependent degradation lesions of the pancreatic beta cells leading to hyperglycemia. A standard antidiabetic drug glibenclamide is most frequently used in alloxan-induced diabetes to compare the efficacy of variety of hypoglycemic agents ( Baldi and Goyal, 2011 , Nawaz et al, 2017a , Nawaz et al, 2017b ).…”

Section: Discussionmentioning

confidence: 99%

“…Diabetes mellitus has become a global problem in recent decades: it is a leading cause of blindness, end stage renal disease and non-traumatic amputation. Its prevalence increased day by day worldwide without any plateau ( Spanou and Tziomalos, 2013 , Nawaz et al, 2017a , Nawaz et al, 2017b ). So, there is need of healthy natural products to cure this disease ( Abbas et al, 2017 , Gohar et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

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Effect of aqueous extract of black pepper and ajwa seed on liver enzymes in alloxan-induced diabetic Wister albino rats

Sarfraz

Khaliq

Khan

et al. 2017

Saudi Pharmaceutical Journal

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The aim of the present study was to investigate the effects of aqueous extract of black pepper and ajwa seed on liver enzymes in alloxan-induced diabetic Wister albino rats to show the preventive and ameliorating effects in hyperglycemic rats. Rats were divided into 6 groups; normal control rats, diabetic control rats, glibenclamide treated rats, black pepper treated rats, ajwa seed treated rats and black pepper plus ajwa seed treated rats. Hyperglycemia was induced in the treatments groups by a single intraperitoneal injection of alloxan at 150 mg/kg body weight. The extracts were administered via oral incubation, doses were glibenclamide 10 mg/kg, black pepper 50 mg/kg, ajwa seed 500 mg/kg and their mixture 500 mg/kg body weight for a period of 8 weeks. Serum glucose, AST, ALT and ALP were assayed using spectrophotometric method. Results showed that ajwa seed and mixture significantly reduced glucose level. AST level was significantly reduced by mixture treated group. No significant difference was observed between different aqueous extract treated group in ALT and ALP level. The study indicates that black pepper and ajwa seed extract to some extend normalized the glucose and liver enzyme activities in alloxanized diabetic rats.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effect of aqueous extract of black pepper and ajwa seed on liver enzymes in alloxan-induced diabetic Wister albino rats

Sarfraz

Khaliq

Khan

et al. 2017

Saudi Pharmaceutical Journal

Self Cite

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“…alpha.,4a,8-tetramethyl-, (2R-cis)-can inhibit the growth of Staphylococcus aureus and Escherichia coli. It is used as an additive to cosmetics and food in industrial production (Nawaz et al, 2017). Cryptomeridiol is a natural product of anti-Alzheimer's disease and antispasmodic nature, and has a significant medicinal value (Olsson and Salmén, 2004).…”

Section: Resultsmentioning

confidence: 99%

“…It is useful for human health. Traditional Chinese medicine pointed out that the aroma of Pterocarpus pedatus Pierre can promote human blood circulation, enhance human immunity and sterilizing itching (Nawaz et al, 2017). Thus, Pterocarpus pedatus Pierre powder before and after extraction with methanol, ethyl acetate and ethanol/benzene solution is subjected to compound or functional group analysis by FT-IR.…”

Section: Introductionmentioning

confidence: 99%

GC–MS explores the health care components in the extract of Pterocarpus pedatus Pierre

Chen

2018

Saudi Journal of Biological Sciences

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Pterocarpus a high-end, expensive furniture materials collectively. Pterocarpus and Pterocarpus products have a certain human health function. Therefore, this paper to Pterocarpus pedatus Pierre as an example, to study its extract on human health beneficial health care ingredients. FT-IR analysis showed that the infrared transmittance of Pterocarpus pedatus Pierre powder after ethanol/benzene extraction was the highest in the infrared spectrum of 400 cm-800 cm, 2750 cm-3200 cm wave number. In the 1750 cm-2400 cm wave segment, methanol, ethyl acetate and ethanol/benzene after the extraction of Pterocarpus pedatus Pierre powder infrared transmittance increased values are basically the same. GC-MS analysis, the health care ingredients in the Pterocarpus pedatus Pierre have cough and phlegm, heat detoxification, enhance human immunity, analgesic and anti-inflammatory and so on. Among them, Homopterocarpin is excellent in inhibiting and killing cancer cell activity; Cryptomeridiol is a natural product with anti-Alzheimer's disease and antispasmodic nature, and its medicinal value is remarkable. Scoparone has a wide range of pharmacological values.

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“…Currently the main use of hormone replacement therapy (HRT) for the treatment of MPS, direct supplement estrogen, long-term HRT can cause vaginal bleeding, breast tenderness, endometrial cancer, breast cancer and other adverse effects. In addition, the effect is not yet with satisfaction—the dose of estrogen on the immune system still has inhibited effect (Ma et al, 2016, Nawaz et al, 2017). Especially the recent discovery shows that it can increase the risk of cardiovascular and cerebrovascular disease and other serious side effects significantly limiting the clinical application.…”

Section: Introductionmentioning

confidence: 99%

Phenylethanoid Glycosides of Cistanche on menopausal syndrome model in mice

Tian

Miao

Bai

et al. 2017

Saudi Pharmaceutical Journal

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Cistanche is the traditional and precious Chinese herbal, with two thousand years of use history in China. It has the effect on tonifying kidney, strong supplement to the liver and kidney, and replenishing essence and blood, known as the "desert ginseng". Here, we explored the mechanism of Phenylethanoid Glycosides of Cistanche (PGC) to the model mice of menopausal syndrome, as well as the therapeutic effect and characteristics of PGC to the menopausal syndrome. In this study, KM mice were reproduced by the complete resection of the ovaries on both sides of the back to establish the model mice of menopausal syndrome (MPS), and received distilled water or drugs, respectively. Model mice received distilled water. Mice received 200 mg/(kg day) high doses of Phenylethanoid Glycosides of Cistanche (HPGC), and 100 mg/(kg day) medium doses of Phenylethanoid Glycosides of Cistanche (MPGC), and 50 mg/(kg day) low doses of Phenylethanoid Glycosides of Cistanche (LPGC). After 21 days, it could determine the number of independent activities and the number of standing, the latent period of first entering the dark room, and the electric number. It also calculated the viscera index of uterus, thymus, spleen, measured the levels of estradiol (E2), testosterone (T), luteinizing hormone (LH), and follicle-stimulating hormone (FSH) in the serum. Furthermore, it observed the pathological changes of uterus, thymus, spleen and pituitary of mice. The results showed that behavioral indicators: Compared with the model group (MG), HPGC, MPGC, LPGC could increase the independent activities ( < 0.01); HPGC, MPGC could increase the number of standing, the latent period of first entering the dark room, and reduce the electric number ( < 0.01); LPGC could increase the number of standing ( < 0.05); Viscera index: Compared with MG, HPGC, MPGC could increase the viscera index of uterus, thymus, spleen ( < 0.01); LPGC could increase the viscera index of uterus ( < 0.05); Serum index: Compared with MG, all groups could decrease the levels of LH in the serum ( < 0.01); HPGC, MPGC could improve the levels of E, T and decrease the levels of LH, FSH in the serum ( < 0.01); LPGC could improve the levels of E and decrease the levels of FSH in the serum ( < 0.05). Meanwhile, it had the trend to improve the levels of T in the serum. Pathological changes: Compared with MG, HPGC could significant improve the pathological changes of uterus, thymus, spleen and pituitary of mice; other groups also has a certain effect. The results indicated that PGC could improve the sex hormone disorder of MPS, and restore the function of uterus, thymus and spleen, with better therapeutic effect on MPS.

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A Review of antihyperlipidemic effect of synthetic phenolic compounds

Cited by 11 publications

References 28 publications

Effect of aqueous extract of black pepper and ajwa seed on liver enzymes in alloxan-induced diabetic Wister albino rats

Effect of aqueous extract of black pepper and ajwa seed on liver enzymes in alloxan-induced diabetic Wister albino rats

GC–MS explores the health care components in the extract of Pterocarpus pedatus Pierre

Phenylethanoid Glycosides of Cistanche on menopausal syndrome model in mice

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