A Review of Antioxidants

Rs, Birangane; Dg, Chole; Reddy, K Sathya Prakash; Shivaji,; Kailasam, S

doi:10.5005/jp-journals-10011-1167

Cited by 3 publications

(2 citation statements)

References 6 publications

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“…The enzymatic antioxidant defense is an important system for preventing and reducing oxidative stress in mammalian cells. Primary enzymatic antioxidants of this defense system, including SOD, CAT, and GPx, can enhance cells' ability to resist oxidative damage caused by H 2 O 2 (Birangane et al., 2011 ; Tan et al., 2020 ). Therefore, to examine the effect of CNPE on the antioxidant enzyme activities in our HepG2 cells, the cells were pretreated with CNPE (1–100 μg/mL) or 10 μM C3G (used as a positive control) for 24 h, followed by 300 μM of H 2 O 2 for 24 h. As shown in Figures 7a–c , the H 2 O 2 treatment only significantly decreased the levels of SOD, CAT, and GPx activities compared to the control group.…”

Section: Resultsmentioning

confidence: 99%

Cleistocalyx nervosum var. paniala berry extract and cyanidin‐3‐glucoside inhibit hepatotoxicity and apoptosis

Panritdum,

Muangnoi,

Tuntipopipat

et al. 2024

Food Science & Nutrition

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Excessive oxidative toxicity in liver cells is a significant risk factor that can cause cellular injury, leading to the development of chronic liver disease (CLD). Natural anthocyanins have been shown to prevent the harmful effects of oxidative toxicity in mammalian cells. Ripe Cleistocalyx nervosum var. paniala berry fruits are rich in anthocyanins, which have been reported to possess many health benefits. Therefore, this study examined the protective effect of ethanolic fruit extract of C. nervosum var. paniala (CNPE) against hydrogen peroxide (H2O2)‐induced oxidative damage and cell death in human hepatoma HepG2 cells. Results showed that CNPE had strong antioxidant capabilities and high amounts of total phenolics and anthocyanins. HPLC analysis showed that CNPE consists of cyanidin‐3‐glucoside (C3G). Our investigations found that HepG2 cells pretreated with CNPE or anthocyanin C3G inhibited H2O2‐induced cellular damage and apoptosis by increasing the viability of cells, the expression of antiapoptotic Bcl‐2 protein, and the activities of cellular antioxidant enzymes, namely SOD, CAT, and GPx. Moreover, both CNPE and C3G significantly suppressed expression of apoptotic proteins (Bax and cytochrome c) and the activities of cleaved caspase‐9 and caspase‐3 caused by H2O2. Our results indicate that CNPE and C3G can suppress H2O2‐induced hepatotoxicity and cell death through stimulation of endogenous antioxidant enzyme activities and inhibition of apoptosis pathway in HepG2 cells. These findings might support development of CNPE as an alternative natural product for preventing CLD.

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Section: Resultsmentioning

confidence: 99%

Cleistocalyx nervosum var. paniala berry extract and cyanidin‐3‐glucoside inhibit hepatotoxicity and apoptosis

Panritdum,

Muangnoi,

Tuntipopipat

et al. 2024

Food Science & Nutrition

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“…Antioxidants are substances produced by body cells and body fluids including saliva and play an important role in various physiologic and metabolic processes of the body. Antioxidants are substances that when present at low concentrations as compared to those of an oxidizable substrate (Example-Proteins, Lipids ), help to delay or prevent oxidation of various substances [3].…”

Section: Discussionmentioning

confidence: 99%

Estimation of Salivary Malondialdehyde Levels in People with Adverse Oral Habits

et al. 2024

IJFMR

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Aims and Objectives Aim of this study was to assess the levels of Salivary Malondialdehyde as an oxidative stress biomarker in people with adverse oral habits. Introduction Habit of consumption of various forms of Tobacco such as Gutka, Supari, Bidi, Cigarette a fairly common habit, especially among males. These harmful products cause imbalance between the free radicals and antioxidants , leading to oxidative stress. The levels of this oxidative stress can be measured by a specific oxidative stress biomarker, that is Malondialdehyde. Materials and Methods A total of 40 , medically fit males were selected for the study. Among these, 20 people had no history of any adverse oral habits.The other 20 males reported having a habit of consuming at least one or more of harmful substances such as Paan, Gutka, Supari like substances. The salivary Malondialdehyde level was calculated in these patients and subsequently, a comparison was made between those with adverse oral habits and those without any such habits. Results: The salivary Malondialdehyde levels were found to be increased in people with adverse oral habits as compared to those without any such habits . The maximum contrast and increase was found in people of age group 40- 50 years. Conclusion :Elevated salivary Malondialdehyde levels, as an oxidative stress biomarker is one of the reliable tools to estimate the level of oxidative stress and chance of other potential damage to the oral mucosa due to consumption of various harmful substances like Pan, Gutka, Supari, Smoking and others .

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Exploring multifunctional antioxidants as potential agents for management of neurological disorders

Sindhu

Kaur

Singh

et al. 2022

Environ Sci Pollut Res

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A Review of Antioxidants

Cited by 3 publications

References 6 publications

Cleistocalyx nervosum var. paniala berry extract and cyanidin‐3‐glucoside inhibit hepatotoxicity and apoptosis

Cleistocalyx nervosum var. paniala berry extract and cyanidin‐3‐glucoside inhibit hepatotoxicity and apoptosis

Estimation of Salivary Malondialdehyde Levels in People with Adverse Oral Habits

Exploring multifunctional antioxidants as potential agents for management of neurological disorders

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