A Review of Candidate Genes for Development of Equine Recurrent Uveitis

Kulbrock, Maike; Distl, O.; Ohnesorge, Bernhard

doi:10.1016/j.jevs.2013.01.005

Cited by 5 publications

(4 citation statements)

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“…can be detected in about 60 percent of the patients [12][13][14][15]. Whether those pathogens cause the destruction of the blood-retina barrier or the barrier is destroyed first, thus enabling pathogens to enter the immune-privileged organ, is under discussion [16]. The treatment options range from immunosuppressive medication to different surgical procedures, for instance, vitrectomy.…”

Section: Introductionmentioning

confidence: 99%

Neutrophil Extracellular Traps in the Pathogenesis of Equine Recurrent Uveitis (ERU)

Fingerhut

Ohnesorge

Borstel

et al. 2019

Cells

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Equine recurrent uveitis (ERU) is considered one of the most important eye diseases in horses and typically appears with relapsing inflammatory episodes without systemic effects. Various disorders have been described as an initial trigger, including infections. Independent of the initiating cause, there are numerous indications that ERU is an immune-mediated disease. We investigated whether neutrophil extracellular traps (NETs) are part of the ERU pathogenesis. Therefore, vitreous body fluids (VBF), sera, and histological sections of the eye from ERU-diseased horses were analyzed for the presence of NET markers and compared with horses with healthy eyes. In addition, NET formation by blood derived neutrophils was investigated in the presence of VBF derived from horses with healthy eyes versus ERU-diseased horses using immunofluorescence microscopy. Interestingly, NET markers like free DNA, histone-complexes, and myeloperoxidase were detected in higher amounts in samples from ERU-diseased horses. Furthermore, in vitro NET formation was higher in neutrophils incubated with VBF from diseased horses compared with those animals with healthy eyes. Finally, we characterized the ability of equine cathelicidins to induce NETs, as potential NET inducing factors in ERU-diseased horses. In summary, our findings lead to the hypothesis that ERU-diseased horses develop more NETs and that these may contribute to the pathogenesis of ERU.

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Section: Introductionmentioning

confidence: 99%

Neutrophil Extracellular Traps in the Pathogenesis of Equine Recurrent Uveitis (ERU)

Fingerhut

Ohnesorge

Borstel

et al. 2019

Cells

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“…3,4 One study found a higher prevalence of ERU in geldings compared with mares and stallions. 5 However, this finding has not been shown in other studies 6,7 and therefore may be a reflection of the general sex distribution in that particular horse population rather than a true sex-specific distribution. Anecdotally, the prevalence of ERU is believed to be higher in areas of continental Europe prone to flooding.…”

Section: Introductionmentioning

confidence: 77%

Risk factors for a first episode of primary uveitis in the UK and proportion of cases that experience recurrence following this first episode

Malalana

Ireland

Pinchbeck

et al. 2022

Equine Veterinary Journal

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Background: Risk factors for a first episode of primary uveitis in horses have not been determined. In addition, disease progression and the proportion of horses that develop recurrence following the original episode are not known. Objectives:To determine the risk factors for the development of a first episode of primary uveitis in horses in the UK and to document the proportion of cases that experience recurrence following this first episode. Study design:Prospective case-control longitudinal study. Methods:Horses with a first episode of primary uveitis between July 2014 and August 2018 were recruited to the study. For each case, two controls were selected.A questionnaire was completed for each horse and multivariable logistic regression analysis was carried out to identify associations between horse and managementlevel variables and the risk of uveitis. Each case was then followed longitudinally to determine the rate of recurrence of uveitis.Results: Twenty-three cases and 46 controls were recruited. Being close to a pig farm (OR 27.8,) and a recent history of flooding of the pasture (OR 15.43, CI 2.80-84.98) was associated with increased risk of uveitis. Being in the same owner's possession for a longer amount of time had a protective effect (OR 0.79, CI 0.68-0.93).Horses recovered uneventfully following treatment and showed no evidence of recurrence in 59.1% of the cases (n = 13). In five horses (22.7%), the initial episode of uveitis could not be controlled and required surgical therapy. Recurrence was observed in four horses (18.2%).Main limitations: Small sample size. Recall bias from owners for some of the data.

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“…Higher prevalence in geldings compared to mares and stallions has been reported (Szemes & Gerhards, 2000). No particular sex related differences in prevalence have been reported (Gilger & Deeg, 2011;Kulbrock et al, 2013). Age of presentation has been reported to vary in different studies (Dwyer et al, 1995;Szemes & Gerhards, 2000).…”

Section: Equine Recurrent Uveitis (Eru)mentioning

confidence: 99%