A review of ligand tethered surface engineered carbon nanotubes

Mehra, Neelesh Kumar; Mishra, Vijay; Jain, Narendra Kumar

doi:10.1016/j.biomaterials.2013.10.032

Cited by 155 publications

(83 citation statements)

References 128 publications

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“…The physical adsorption of polymers or biomolecules onto CNTs can be achieved with the assistance of surfactants and linking molecules [5,19]. A recent study demonstrated 57% enzymatic activity was remained when the enzyme was conjugated to SWCNT via a linker molecule, versus 27% activity upon direct adsorption [36].…”

Section: Non-covalent Immobilizationmentioning

confidence: 99%

“…Carbon nanotubes consist of either a single (singlewalled carbon nanotube, SWCNT), double (double-walled carbon nanotube, DWCNT) or multi (multi-walled carbon nanotube, MWCNT) concentric graphene cylindrical layers, resulting in hollow tubes with high aspect ratios. In addition, CNTs can be functionalized with different chemical groups either covalently or noncovalently, making CNTs biocompatible for conjugation with biomolecules and favorable candidates for bioanalytical applications [5,6]. In particular, SWCNTs possess an ideal combination of biocompatibility and an intrinsic near-infrared, non-blinking, nonphotobleaching fluorescence [7].…”

Section: Introductionmentioning

confidence: 99%

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Protein functionalized carbon nanomaterials for biomedical applications

Oliveira

Bisker

Bakh

et al. 2015

Carbon

191

111

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a b s t r a c tSince the discovery of low-dimensional carbon allotropes, there is increasing interest in using carbon nanomaterials for biomedical applications. Carbon nanomaterials have been utilized in the biomedical field for bioimaging, chemical sensing, targeting, delivery, therapeutics, catalysis, and energy harvesting. Each application requires tailored surface functionalization in order to take advantage of a desired property of the nanoparticles. Herein, we review the surface immobilization of bio-molecules, including proteins, peptides, and enzymes, and present the recent advances in synthesis and applications of these conjugates. The carbon scaffold and the biological moiety form a complex interface which presents a challenge for achieving efficient and robust binding while preserving biological activity. Moreover, some applications require the utilization of the protein-nanocarbon system in a complex environment that may hinder its performance or activity. We analyze different strategies to overcome these challenges when using carbon nanomaterials as protein carriers, explore various immobilization techniques along with characterization methods, and present recent demonstrations of employing these systems for biomedical applications. Finally, we consider the challenges and future directions of this field.

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Section: Non-covalent Immobilizationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Protein functionalized carbon nanomaterials for biomedical applications

Oliveira

Bisker

Bakh

et al. 2015

Carbon

191

111

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“…DTX-CNTs exhibited superior drug release profile especially at acidic pH corresponding to conditions existing at tumorous site. So, carboxylated nanotubes present themselves as potential cargo for anticancer agents and can bring upheaval in the field of cancer therapy but in vivo studies shall be essential to have better insight of their toxicological profile (54)(55)(56)(57). Although, higher hemolytic toxicity of naked CNTs and dendrimer mandates their surface modification by some appropriate strategy (like PEGylation).…”

Section: Resultsmentioning

confidence: 99%

Dendrimer, Liposomes, Carbon Nanotubes and PLGA Nanoparticles: One Platform Assessment of Drug Delivery Potential

Mody¹,

Tekade²,

Mehra³

et al. 2014

AAPS PharmSciTech

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116

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Abstract. Liposomes (LIP), nanoparticles (NP), dendrimers (DEN), and carbon nanotubes (CNTs), represent eminent classes of drug delivery devices. A study was carried out herewith by employing docetaxel (DTX) as model drug to assess their comparative drug delivery potentials. Under optimized conditions, highest entrapment of DTX was observed in CNT-based formulation (DTX-CNTs, 74.70± 4.9%) followed by nanoparticles (DTX-NP, 62.34±1.5%), liposome (49.2±1.51%), and dendrimers (28.26± 1.74%). All the formulations were found to be of nanometric size. In vitro release studies were carried out in PBS (pH 7.0 and 4.0), wherein all the formulations showed biphasic release pattern. Cytotoxicity assay in human cervical cancer SiHa cells inferred lowest IC 50 value of 1,235.09±41.93 nM with DTX-CNTs, followed by DTX-DEN, DTX-LIP, DTX-NP with IC 50 values of 1,571.22±151.27, 1,653.98±72.89, 1,922.75±75.15 nM, respectively. Plain DTX showed higher hemolytic toxicity of 22.48±0.94%, however loading of DTX inside nanocarriers drastically reduced its hemolytic toxicity (DTX-DEN, 17.22±0.48%; DTX-LIP, 4.13±0.19%; DTX-NP, 6.43±0.44%; DTX-CNTs, 14.87±1.69%).

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“…The structures of these two CNTs were indicated in Figure 1. Moreover, MWCNTs can be further divided into two subtypes: doublewalled CNTs (DWCNTs) and triple-walled CNTs (TWCNTs) [33]. MWCNTs consist of several concentric layers of rolled graphite; these concentric layers have an inner diameter of 1 to 3 nm and an outer diameter of 2 to 100 nm [34].…”

Section: Character and Performance Properties Of Cntsmentioning

confidence: 99%

The Advances of Carbon Nanotubes in Cancer Diagnostics and Therapeutics

Zhou

Zhang

Wang

et al. 2017

Journal of Nanomaterials

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Carbon nanotubes (CNTs), one of the unique one-dimensional nanomaterials, have gained great attention because of their specific characters, versatile functionalization chemistry, and biological compatibility in the past few decades. CNTs can be functionalized via different methods to perform their specific functions. CNTs have been used in various areas of biomedicine as nanocarriers, including cancer diagnosis and therapy. Different molecules such as peptide, antigen, and nucleic acid can be delivered to cancer cells by CNTs with high efficiency. In this review, we summarized the properties of CNTs and the method of CNTs functionalization and illustrated their application in cancer diagnosis and therapy.

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A review of ligand tethered surface engineered carbon nanotubes

Cited by 155 publications

References 128 publications

Protein functionalized carbon nanomaterials for biomedical applications

Protein functionalized carbon nanomaterials for biomedical applications

Dendrimer, Liposomes, Carbon Nanotubes and PLGA Nanoparticles: One Platform Assessment of Drug Delivery Potential

The Advances of Carbon Nanotubes in Cancer Diagnostics and Therapeutics

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