A review of novel dental caries preventive material: Casein phosphopeptide–amorphous calcium phosphate (CPP–ACP) complex

Farooq, Imran; Moheet, Imran Alam; Imran, Z; Farooq, Umer

doi:10.1016/j.ksujds.2013.03.004

Cited by 38 publications

(37 citation statements)

References 15 publications

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“…Dental caries is a complex disease that has multiple contributing factors [1]. One destructive form of tooth decay that commonly affects young children is early childhood caries (ECC) [2].…”

Section: Introductionmentioning

confidence: 99%

Antifungal effectiveness of virgin coconut oil mousse against Candida albicans biofilm in children with early childhood caries

Monica

Fauziah²,

Budiardjo³

et al. 2018

jos

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Introduction: Early childhood caries is defined as the presence of one or more decayed teeth, missing (due to caries) or filled teeth surface in a child 71 months of age or younger. The presence of Candida albicans will increase caries pathogenicity. Objectives: The objective of this study was to analyze the antifungal effectiveness of virgin coconut oil (VCO) mousse against viability of C. albicans biofilm in children with early childhood caries. Material and methods: In this experimental laboratory study, C. albicans biofilm was exposed to three concentrations of VCO mousse, namely 0.8%, 8% and 80%. C. albicans biofilm viability was tested using crystal violet 0.5% and a colony forming unit assay. Statistical analysis was conducted using 1-way ANOVA. Results: VCO mousse 80% showed optical density and total viable colony count (CFU/ml) values significantly different compared to VCO mousse 0.8% and 8% (p < 0.05). Conclusions: VCO mousse exhibited antifungal effect against viability of C. albicans biofilm in children with early childhood caries.

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Section: Introductionmentioning

confidence: 99%

Antifungal effectiveness of virgin coconut oil mousse against Candida albicans biofilm in children with early childhood caries

Monica

Fauziah²,

Budiardjo³

et al. 2018

jos

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“…F r o m m i l k p r o t e i n s m a n y p e p t i d e s (caseinophosphopeptides-CPPs) with mineral (Ca 2+ , Fe 2+ , Zn 2+ ) chelation properties have been reported which also act as antioxidant due to metal chelation. Casein and its derived peptides are most studied and have most potent mineral binding properties in particular CPP's (Farooq et al 2013). CPPs are suitable supplements for fortifying foods, since Fe bound to CPPs presents good bioavailability with increased solubility and the prevention of interactions with other minerals (Lopez and Martos (2004).…”

Section: Introductionmentioning

confidence: 99%

Iron (II)-chelating activity of buffalo αS-casein hydrolysed by corolase PP, alcalase and flavourzyme

et al. 2014

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Iron is a vital substance for human health which participates in many biochemical reactions. It also act as initiator for many harmful oxidative process. Buffalo αS-casein enriched fraction (80 %) was hydrolysed independently by corolase PP (H1), alcalase (H2), flavourzyme (H3) and sequentially by alcalase-flavourzyme (H4). After ultrafiltration (10 and 3 kDa) hydrolysates were analysed for their iron chelation activity using ferrozine. For H1 group of hydrolysates highest iron (II)-chelation activity (265.58 μM Fe(2+/)mg protein) was found after 8 h of hydrolysis for H2 (267.56 μM Fe(2+/)mg protein) and H3 group of hydrolysates (380.68 μM Fe(2+/)mg protein) after 6 h of hydrolysis. Sequential hydrolysis was not effective for iron (II)-chelation activity. 3 kDa fractions show higher iron (II)-chelation activity than 10 kDa fraction. Flavourzyme was more effective for generation of iron (II)-chelating peptides from buffalo αS-casein.

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“…Syarat bahan remineralisasi yang ideal adalah dapat melepaskan ion kalsium dan fosfat, mencegah pembentukan kalkulus, serta bekerja baik pada kondisi saliva yang sedikit dan pada lingkungan yang asam. 6,7 Bahan dengan kriteria tersebut adalah CPP-ACPF (casein phosphopeptide amorphouscalcium phosphate +  uoride 900 ppm). 4,6,8 Lama aplikasi minimal CPP-ACPF sesuai anjuran pabrik adalah 3 menit, kemudian sisa di dalam mulut dapat diludahkan dan dianjurkan untuk menghindari pembilasan.…”

Section: Pendahuluanunclassified

“…6,7 Bahan dengan kriteria tersebut adalah CPP-ACPF (casein phosphopeptide amorphouscalcium phosphate +  uoride 900 ppm). 4,6,8 Lama aplikasi minimal CPP-ACPF sesuai anjuran pabrik adalah 3 menit, kemudian sisa di dalam mulut dapat diludahkan dan dianjurkan untuk menghindari pembilasan. Pasien dianjurkan untuk tidak makan dan minum selama 30 menit setelah pemakaian, efek maksimal didapatkan dengan mempertahankan pasta CPP-ACPF selama mungkin di dalam mulut.…”

Section: Pendahuluanunclassified

“…9,10 Berbagai penelitian mengindikasikan bahwa CPP-ACPF dapat meningkatkan kekerasan email, tetapi pengaruh aplikasi pasta CPP-ACPF dalam waktu aplikasi yang lebih lama, dan total waktu yang dibutuhkan oleh CPP-ACPF dalam proses remineralisasi masih belum diketahui. 6 Penelitian ini bertujuan untuk mengetahui pengaruh variasi lama aplikasi bahan remineralisasi CPP-ACPF terhadap kekerasan email.…”

Section: Pendahuluanunclassified

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Pengaruh lama aplikasi bahan remineralisasi casein phosphopeptide amorphous calcium phosphate fluoride (CPP-ACPF) terhadap kekerasan email

Wiryani

Sujatmiko

Bikarindrasari

2016

Majalah Kedokteran Gigi Indonesia

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The effect of application time of CPP-ACPF on enamel hardness. Remineralization process can increase the hardness of enamel due to demineralization process. CPP-ACPF is a material used for enhancing remineralization. However, the application time of CPP-ACPF remain controversial among previous studies. This study was aimed to investigate the effect of various application times of CPP-ACPF on enamel hardness. Thirty premolar teeth were mounted on self cure acrylic resin, and were divided into 5 groups. Demineralization process was performed, and enamel hardness (pre-est) was measured by Vickers Hardness Tester. Remineralization was performed using CPP-ACPF in various application times: 3, 15, 30, 60 minutes, and the control group was only immersed in artificial saliva for 60 minutes, then enamel hardness was measured (posttest). Data were analyzed using paired t-test, one-way ANOVA, and post-hoc Bonferroni. The result of paired t-test showed that all the groups, except the control group, have an increasing enamel hardness that was statistically significant. One-way ANOVA results showed no statistically significant difference among the groups at pretest, but one-way ANOVA results showed statistically significant difference at posttest. Post hoc Bonferroni showed that the significantly difference at posttest occurred between all the treatment groups against the control group, but there were no significant differences between the 3 minutes group to 15 minutes group, between 15 minutes group to 30 minutes group, and between 30 minutes group to 60 minutes group. It was concluded that various application times of CPP-ACPF had an effect on increasing enamel hardness. ABSTRAKProses remineralisasi dapat meningkatkan kekerasan email yang menurun akibat demineralisasi. Bahan remineralisasi yang ideal adalah CPP-ACPF. Terdapat perbedaan lama aplikasi CPP-ACPF dalam berbagai penelitian, selain itu total lama aplikasi yang dibutuhkan CPP-ACPF dalam mekanisme remineralisasi belum diketahui. Penelitian ini dilakukan untuk mengetahui pengaruh lama aplikasi CPP-ACPF terhadap kekerasan email. Tiga puluh mahkota gigi premolar yang ditanam dalam resin akrilik self cure dibagi menjadi lima kelompok, kemudian dilakukan proses demineralisasi. Kekerasan email kemudian diukur menggunakan alat Vickers Hardness Tester. Proses remineralisasi menggunakan CPP-ACPF dilakukan pada masing-masing kelompok dalam berbagai lama aplikasi yaitu 3 menit, 15 menit, 30 menit, 60 menit, serta perendaman dalam saliva buatan selama 60 menit (kontrol). Kekerasan email kemudian diukur kembali (posttest). Data diuji secara statistik menggunakan t-test berpasangan, one-way ANOVA dan post hoc Bonferroni. Hasil paired t-test menunjukkan bahwa seluruh kelompok, kecuali kelompok kontrol, mengalami peningkatan rata-rata kekerasan email secara signifikan. Hasil uji one-way ANOVA pada pretest menunjukkan tidak ada perbedaan kekerasan email yang signifikan. Hasil uji one-way ANOVA pada posttest menunjukkan terdapat perbedaan kekerasan email yang signifikan. Hasil uji post Hoc Bonferroni menunjukkan bahwa terdapat perbedaan kekerasan email yang signifikan pada seluruh kelompok perlakuan terhadap kelompok kontrol, tetapi perbedaan kekerasan email antara kelompok lama aplikasi 3 menit dengan 15 menit, antara lama aplikasi 15 menit dengan 30 menit, serta antara lama aplikasi 30 menit dengan 60 menit tidak menunjukkan perbedaan kekerasan email yang signikan. Kesimpulan penelitian ini adalah berbagai lama aplikasi CPP-ACPF berpengaruh terhadap peningkatan kekerasan email.

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A review of novel dental caries preventive material: Casein phosphopeptide–amorphous calcium phosphate (CPP–ACP) complex

Cited by 38 publications

References 15 publications

Antifungal effectiveness of virgin coconut oil mousse against Candida albicans biofilm in children with early childhood caries

Antifungal effectiveness of virgin coconut oil mousse against Candida albicans biofilm in children with early childhood caries

Iron (II)-chelating activity of buffalo αS-casein hydrolysed by corolase PP, alcalase and flavourzyme

Pengaruh lama aplikasi bahan remineralisasi casein phosphopeptide amorphous calcium phosphate fluoride (CPP-ACPF) terhadap kekerasan email

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