A review of the Chido/Rodgers blood group

Abstract

These antibodies are high-titered and have low avidity, they are red cell, white cell antibodies, they are clinically insignificant, are not reactive with enzyme-treated red cells, and can be absorbed with white cells!" Then the chorus of other blind, wise blood bankers said, "NO, THEY ARE NOT!" based on memories of discussions about these antibodies back in the 1970s and the fable of the elephant and blind wise men-r. mougey

Simulated RBC antibody identification training panels created using SARS‐CoV‐2 kodecytes and immune plasma

“…1 Secondarily acquired antigens, for example Lewis, 6 Chido/Rodgers, 7 some drugs, 8 and Kode Technology constructs once attached to the membrane behave like intrinsic RBC antigens and react accordingly when the corresponding antibody is present. [1][2][3][5][6][7]9 Normally reagent cells in an antibody screening or identification panel contain a range of different RBCs selected as a set for their complementary antigenic profiles. However, here with SASID panels, kodecytes and unmodified cells were organized as reagent cell panels (screening and identification) to mimic antigenic variations (see exemplars, Figures 2 & S1-S8).…”

“…The antigen on the RBCs in the SASID panels is not a natural RBC antigen, but is instead a conserved viral peptide antigen sequence of SARS‐CoV‐2 secondarily attached to the RBC membrane using Kode technology. 1 Secondarily acquired antigens, for example Lewis, 6 Chido/Rodgers, 7 some drugs, 8 and Kode Technology constructs once attached to the membrane behave like intrinsic RBC antigens and react accordingly when the corresponding antibody is present. 1 , 2 , 3 , 5 , 6 , 7 , 9 …”

“… 1 Secondarily acquired antigens, for example Lewis, 6 Chido/Rodgers, 7 some drugs, 8 and Kode Technology constructs once attached to the membrane behave like intrinsic RBC antigens and react accordingly when the corresponding antibody is present. 1 , 2 , 3 , 5 , 6 , 7 , 9 …”

Novel Associations Between Major Histocompatibility Complex and Pediatric‐onset Inflammatory Bowel Disease

“…C4B protein is thought to bind preferentially to hydroxyl groups, such as those commonly present on carbohydrates on bacterial surfaces. C4B thus participates in host defense against microbes (11). Accordingly, it is possible that a C4B ‐deficient patient may have a decreased defense against intestinal microbes and may be more prone to develop complications after surgery.…”

“…C4 gene products are involved in the activation of the complement cascade in the classical and mannose-binding lectin pathways, making them important in both innate immunity and adaptive humoral immune reactions. The deficiencies of C4 have been associated with susceptibility to systemic lupus erythematosus, infectious diseases, and autoimmune conditions (10,11).…”