A Review of the Genomics of Gastric Cancer

Hamilton, James P.; Meltzer, Stephen J.

doi:10.1016/j.cgh.2006.01.019

Cited by 98 publications

(87 citation statements)

References 138 publications

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“…Genetic and epigenetic alterations play important roles in the development and progression of gastric cancer [1,2] . Considerable attention has been given to the potential role of tyrosine kinases in gastric cancer [3][4][5][6] .…”

Section: Introductionmentioning

confidence: 99%

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Overexpression of the receptor tyrosine kinase EphA4 in human gastric cancers

Oki¹,

Yamamoto²,

Taniguchi³

et al. 2008

WJG

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recurrence. EphA4 overexpression was also correlated with FGFR1 overexpression. Patients with EphA4-positive cancer had significantly shorter overall survival periods than did those with EphA4-negative cancer (P = 0.0008). The mRNAs for ephrin ligands were coexpressed in various combinations in gastric cancer cell lines and cancer tissues. Downregulation of EphA4 expression by siRNA in EphA4-overexpressing gastric cancer cell lines resulted in a significant decrease in cell growth. CONCLUSION: Our results suggest that overexpression of EphA4 plays a role in gastric cancer.

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Section: Introductionmentioning

confidence: 99%

“…Gastric cancer is the fourth most common cancer and the second leading cause of cancer-related death in the world [1] . Genetic and epigenetic alterations play important roles in the development and progression of gastric cancer [1,2] .…”

Section: Introductionmentioning

confidence: 99%

Overexpression of the receptor tyrosine kinase EphA4 in human gastric cancers

Oki¹,

Yamamoto²,

Taniguchi³

et al. 2008

WJG

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“…These systems agree that the intestinal/differentiated/ expending type and diffuse/undifferentiated/infiltrative type differ greatly in terms of epidemiology, pathogenesis, genetic profile, and clinical outcome [8,[43][44][45][46] . Signet-ring cell carcinoma belongs to the diffuse/undifferentiated/infiltrative type group.…”

Section: Discussionmentioning

confidence: 90%

“…As a result, the diffuse type now accounts for about 30% of gastric carcinomas in some reported series [7] . Intestinal-type and diffuse-type gastric cancer differ in their epidemiology, pathogenesis, genetic profile, and clinical outcome [8] .…”

Section: Introductionmentioning

confidence: 99%

LINE-1 family member GCRG123 gene is up-regulated in human gastric signet-ring cell carcinoma

Wang

Wang²,

Wu³

et al. 2008

WJG

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AIM:To analyze the expression profiles of a human gastriccancer-related gene, GCRG123 , in human gastric signetring cell carcinoma tissues, and to perform bioinformatics analysis on GCRG123 . METHODS:In situ hybridization was used to explore the GCRG123 expression pattern in paraffin-embedded gastric tissues, including 15 cases of signet-ring cell carcinoma, 15 of intestinal-type adenocarcinoma, and 15 of normal gastric mucosa. Northern blotting was used to analyze the differences in GCRG123 expression between stomach signet-ring cell carcinoma and intestinal-type adenocarcinoma tissues. Online software, including BLAST, Multalin and BLAT, were applied for bioinformatics analysis. National Center for Biotechnology Information (NCBI) and the University of California Santa Cruz (UCSC) databases were used for the analyses. RESULTS:The in situ hybridization signal appeared as blue precipitates restricted to the cytoplasm. Ten out of 15 cases of gastric signet ring cell carcinoma, normal gastric mucosal epithelium and pyloric glands showed high GCRG123 expression. Low GCRG123 expression was observed in gastric intestinal-type adenocarcinoma and normal gastric glands. Northern blotting revealed that GCRG123 was up-regulated in signet-ring cell carcinoma tissue but down-regulated in intestinal-type adenocarcinoma tissue. BLAST and Multalin analyses revealed that the GCRG123 sequence had 92% similarity with the ORF2 sequence of human long interspersed nuclear element retrotransposons (LINE-1, L1).BLAT analysis indicated that GCRG123 mapped to all chromosomes. GCRG123 was found to integrate in the intron-17 and -23 of Rb, 5' flanking region of IL-2 and clotting factor Ⅸ genes. LINE-1 family member GCRG123 gene is up-regulated in human gastric signet-ring cell carcinoma. World

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“…Tumorigenesis is a multi-step process accompanied with genetic alterations of precancerous cells and the simultaneous microenvironment building up, which promotes transformation [13] . CA is a type of zinccontaining metalloenzyme.…”

Section: Discussionmentioning

confidence: 99%

Reduction of CAII expression in gastric cancer: Correlation with invasion and metastasis

Xie

Lei

et al. 2012

Chin. J. Cancer Res.

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Objective: Human carbonic anhydrases II (CAII) gene plays an important role in different cancer. However, its relevance to gastric cancer (GC) remains unclear. In the present study, we aimed to investigate the expression of CAII in GC and explore its correlation with some clinicopathologic characteristics of GC.Methods: The expression of CAII in 20 specimens of normal gastric mucosa, 38 specimens of intraepithelial neoplasia and 112 specimens of gastric carcinoma were detected by immunohistochemical techniques. Survival in GC with CAII expression was studied.Results: The positive rate of CAII protein in normal gastric mucosa was significantly higher than that in intraepithelial neoplasia and gastric carcinoma (100% vs. 63.16% and 28.57%, P<0.001). The positive rate of CAII protein was significantly higher in gastric carcinoma at early stages than that at advanced stages (70.0% vs. 19.57%, P<0.001). The positive rate of CAII protein was significantly lower in gastric carcinoma with lymph node metastases than that without lymph node metastases (10.81% vs. 37.33%, P<0.05). Furthermore, the positive rate of CAII protein was significantly lower in poorly-differentiated gastric carcinoma than in moderately-or well-differentiated gastric carcinoma (15.94% vs. 31.03% or 60.00%, P<0.05). Moreover, CAII expression was not related with sex, age and tumor size. The patients with CAII-positive tumors showed a better survival rate than those with CAII-negative tumors (P=0.024, log-rank test).Conclusion: CAII expression was related with stages and lymph node metastases in gastric carcinoma. The reduction of CAII expression in GC might promote tumor cell motility and contribute to tumor growth and metastasis.

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A Review of the Genomics of Gastric Cancer

Cited by 98 publications

References 138 publications

Overexpression of the receptor tyrosine kinase EphA4 in human gastric cancers

Overexpression of the receptor tyrosine kinase EphA4 in human gastric cancers

LINE-1 family member GCRG123 gene is up-regulated in human gastric signet-ring cell carcinoma

Reduction of CAII expression in gastric cancer: Correlation with invasion and metastasis

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