A review of the most important natural antioxidants and effective medicinal plants in traditional medicine on prostate cancer and its disorders

Basati, Gholam; Ghanadi, Pardis; Abbaszadeh, Sepideh

doi:10.34172/jhp.2020.15

Cited by 21 publications

(21 citation statements)

References 63 publications

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“…Since green tea is one of the most widely consumed beverages in the world [ 18 ] and tea catechins have important antioxidant and anticancer properties [ 7 ], it is imperative that we fully understand the potential metabolic pathways involved in the biotransformation of these substances. Once these metabolites are characterized, further studies can examine their individual bioactive properties or toxicological implications.…”

Section: Discussionmentioning

confidence: 99%

“…These antioxidants include vitamins (C and E), herbs and spices, and natural products from plants [ 1 , 6 ]. They are used as preservatives and bioactive molecules for prevention against diseases such as cancer [ 7 ], obesity [ 8 ], neurological disorders [ 9 ], aging [ 10 ], and cardiovascular diseases [ 11 ]. They are often considered a healthier alternative to synthetic antioxidants [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

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Structural Elucidation of Novel Stable and Reactive Metabolites of Green Tea Catechins and Alkyl Gallates by LC-MS/MS

Ousji

Sleno

2022

Antioxidants

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Synthetic gallic acid derivatives are employed as additives in food, personal care products, and pharmaceutical formulations. Despite their widespread use, little is known about their human exposure, health effects, and metabolism. Green tea catechins are natural antioxidants, known for their health-promoting properties, and are also employed as food additives or in personal care products. The objective of this study was to establish metabolic pathways involved in the biotransformation of green tea catechins and synthetic gallate esters. Liquid chromatography coupled with high-resolution tandem mass spectrometry (LC-HRMS/MS) was used to elucidate oxidative and methylated metabolites, in addition to glutathione conjugates, formed in vitro using human liver microsomal incubations. The developed method was applied to 14 different parent compounds with a wide range of polarities, for the structural elucidation of many known and novel metabolites. These results serve to inform about the wide variety of possible metabolites formed upon exposure to these compounds.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Structural Elucidation of Novel Stable and Reactive Metabolites of Green Tea Catechins and Alkyl Gallates by LC-MS/MS

Ousji

Sleno

2022

Antioxidants

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“…These are the compounds that have been said to improve conditions of mild prostate hypertrophy and enlarged prostate. It was found that oral administration of pygeum inactivates the androgen receptor and inhibits the growth of prostate cancer cells [ 56 , 57 , 58 , 59 , 60 ]. Furthermore, P. africana has antibacterial properties, and it has been proved that different extracts in organic solvents are able to inhibit the growth of varies of bacterial species [ 61 , 62 ].…”

Section: Introductionmentioning

confidence: 99%

Changes in the Mechanical Properties of Alginate-Gelatin Hydrogels with the Addition of Pygeum africanum with Potential Application in Urology

Kurowiak

Kaczmarek-Pawelska

Mackiewicz

et al. 2022

IJMS

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New hydrogel materials developed to improve soft tissue healing are an alternative for medical applications, such as tissue regeneration or enhancing the biotolerance effect in the tissue-implant–body fluid system. The biggest advantages of hydrogel materials are the presence of a large amount of water and a polymeric structure that corresponds to the extracellular matrix, which allows to create healing conditions similar to physiological ones. The present work deals with the change in mechanical properties of sodium alginate mixed with gelatin containing Pygeum africanum. The work primarily concentrates on the evaluation of the mechanical properties of the hydrogel materials produced by the sol–gel method. The antimicrobial activity of the hydrogels was investigated based on the population growth dynamics of Escherichia coli ATCC 25922 and Staphylococcus aureus ATCC 25923, as well as the degree of degradation after contact with urine using an innovative method with a urine flow simulation stand. On the basis of mechanical tests, it was found that sodium alginate-based hydrogels with gelatin showed weaker mechanical properties than without the additive. In addition, gelatin accelerates the degradation process of the produced hydrogel materials. Antimicrobial studies have shown that the presence of African plum bark extract in the hydrogel enhances the inhibitory effect on Gram-positive and Gram-negative bacteria. The research topic was considered due to the increased demand from patients for medical devices to promote healing of urethral epithelial injuries in order to prevent the formation of urethral strictures.

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“…The curious expression that PSMs are natural products underpins the belief that as "natural" products, medicinal plants are "safe" or "safer" than conventional medicines. Indeed, some PSMs in medicinal plants are intrinsically toxic [17,18] or are activated by enzyme systems in humans to toxic compounds [19]. There are also certain classes of PSMs with endocrine-disrupting capabilities [20][21][22].…”

Section: Introductionmentioning

confidence: 99%

Natural Does Not Mean Safe

Afonne¹,

Ifediba²

2022

Medicinal Plants

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Medicinal plants are rich sources of natural products, the principal constituents in herbal medicines, utilized for the treatment and prevention of diseases. High consumer expectations for health care, in the face of soaring cost of conventional pharmaceuticals, have popularized herbal medicines in different regions of the world. The consumption of these botanicals and their products has recently gained much impetus with the assumption that since these active principles in them are natural, they are, therefore, safe. Assertive as this idea could be, scrutinizing the perspectives on which it is premised is critical in minimizing probable risk on human health. Most plant parts are repositories of natural toxins, phytosteroids, and bioaccumulated toxicants, all of which are driven by natural processes. Besides intrinsic toxicity possessed by phytotoxins, some innocuous chemicals in medicinal plants can be biotransformed to toxic components. Some chemicals in medicinal plants that are of safety concerns include the endocrine-disrupting chemicals such as phytoestrogens, bisphenol A, and phthalates, among others. The persistent, bioaccumulative, and toxic metals have also been identified in medicinal plants. Some of these chemicals have been found to cause metabolic derangement and carcinogenicity. It is, therefore, imperative that linking natural products to safety should rather be empirical.

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A review of the most important natural antioxidants and effective medicinal plants in traditional medicine on prostate cancer and its disorders

Cited by 21 publications

References 63 publications

Structural Elucidation of Novel Stable and Reactive Metabolites of Green Tea Catechins and Alkyl Gallates by LC-MS/MS

Structural Elucidation of Novel Stable and Reactive Metabolites of Green Tea Catechins and Alkyl Gallates by LC-MS/MS

Changes in the Mechanical Properties of Alginate-Gelatin Hydrogels with the Addition of Pygeum africanum with Potential Application in Urology

Natural Does Not Mean Safe

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