A review on mechanism of inhibition of advanced glycation end products formation by plant derived polyphenolic compounds

Anwar, Shehwaz; Khan, Shahper N.; Almatroudi, Ahmad; Khan, Amjad Ali; Alsahli, Mohammed A; Almatroodi, Saleh A.; Rahmani, Arshad Husain

doi:10.1007/s11033-020-06084-0

Cited by 96 publications

(72 citation statements)

References 117 publications

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“…The flavonoids additionally stabilize the HSA structure, which explains the mechanism of their action as antiglycating and antifibrillating agents [ 154 ]. It is assumed that polyphenolic compounds have pleiotropic effects and prevent glycation at different levels, through the regulation of glucose metabolism, metal chelation, trapping of intermediate dicarbonyl compounds, influence on the insulin resistance of cells, and finally, through the activation of the signaling pathway of the insulin-like growth factor receptor [ 300 ].…”

Section: Integrative Properties Of Albumin In Diagnostics and Therapymentioning

confidence: 99%

Serum Albumin in Health and Disease: Esterase, Antioxidant, Transporting and Signaling Properties

Belinskaia

Voronina

Шмурак

et al. 2021

IJMS

161

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Being one of the main proteins in the human body and many animal species, albumin plays a decisive role in the transport of various ions—electrically neutral and charged molecules—and in maintaining the colloidal osmotic pressure of the blood. Albumin is able to bind to almost all known drugs, as well as many nutraceuticals and toxic substances, largely determining their pharmaco- and toxicokinetics. Albumin of humans and respective representatives in cattle and rodents have their own structural features that determine species differences in functional properties. However, albumin is not only passive, but also an active participant of pharmacokinetic and toxicokinetic processes, possessing a number of enzymatic activities. Numerous experiments have shown esterase or pseudoesterase activity of albumin towards a number of endogeneous and exogeneous esters. Due to the free thiol group of Cys34, albumin can serve as a trap for reactive oxygen and nitrogen species, thus participating in redox processes. Glycated albumin makes a significant contribution to the pathogenesis of diabetes and other diseases. The interaction of albumin with blood cells, blood vessels and tissue cells outside the vascular bed is of great importance. Interactions with endothelial glycocalyx and vascular endothelial cells largely determine the integrative role of albumin. This review considers the esterase, antioxidant, transporting and signaling properties of albumin, as well as its structural and functional modifications and their significance in the pathogenesis of certain diseases.

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Section: Integrative Properties Of Albumin In Diagnostics and Therapymentioning

confidence: 99%

Serum Albumin in Health and Disease: Esterase, Antioxidant, Transporting and Signaling Properties

Belinskaia

Voronina

Шмурак

et al. 2021

IJMS

161

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“…The reason is that the purification methods of the drugs studied in these experiments are not uniform, or the way of action of drugs on diabetic cataract is relatively single, so it may be weak for the drugs on the effect of diabetic cataract with complex pathogenesis in actual clinical conditions. PCA is a phenolic compound with anti-proliferative activity, antioxidant activity, protein glycosylation inhibitory activity, 3 , 4 and can prevent the expression of AGEs and TGF-β1 receptors in human lens epithelial cells cultured under diabetic conditions. 5 According to the above studies, it can be found that PCA can improve disease progression through multiple pathways and targets, which is exactly a characteristic of therapeutic drugs for complex diseases.…”

Section: Discussionmentioning

confidence: 99%

“…Protocatechualdehyde (PCA) is a phenolic compound found in the roots of Salvia miltiorrhiza with anti-proliferative and antioxidant activities. 3 , 4 According to reports, protocatechualdehyde has strong protein glycosylation inhibitory activity, 3 , 4 and has an inhibitory effect on the formation of AGEs-BSA in vivo and in vitro, and can inhibit the expression of AGEs and TGF-β1 receptors in human lens epithelial cells cultured under diabetic conditions. 5 In streptozotocin (STZ)-induced diabetic rats, oral PCA for 8 weeks could significantly improve the development of diabetic cataract, 5 which indicated that PCA may be an effective drug for the treatment of diabetic complications.…”

Section: Introductionmentioning

confidence: 99%

A Network Pharmacology Study on the Molecular Mechanism of Protocatechualdehyde in the Treatment of Diabetic Cataract

Cheng

Song

Wang

et al. 2021

DDDT

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Purpose Protocatechualdehyde (PCA) is a phenolic compound found in the roots of Salvia miltiorrhiza with anti-proliferative and antioxidant activities. At present, there are few studies on protocatechualdehyde against diabetic cataract (DC), and there is also lack of systematic research on the mechanism of protocatechualdehyde. Therefore, this study tried to comprehensively clarify the targets and complex mechanisms of PCA against DC from the perspective of network pharmacology. Materials and Methods Through collecting relevant targets from the databases, GO and KEGG enrichment analysis were performed on the potential targets. Moreover, core genes were identified by topological analysis of protein–protein interaction (PPI) network and gene–phenotype correlation analysis. Results The results indicated that protocatechualdehyde may be closely related to targets such as AKT1, MAPK3 and HDAC3, as well as signal pathways such as MAPK signaling pathway, PI3K-Akt signaling pathway and AGE-RAGE signaling pathway in diabetic complications. Conclusion Together, the present study systematically clarified the possible mechanisms of protocatechualdehyde in the treatment of diabetic cataract and provided new ideas for the drug research of this disease.

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“…The AGEs formation affects insulin action pathways producing insulin resistance and tissue damage to many organs such as the pancreas, liver, and kidney. Bioactive compounds prevent AGES formation through as follows the mechanism of actions: 1) eliminating ROS formation during glycation, 2) inhibiting Schiff base, Amadori products, and their subsequent formation of dicarbonyl groups, 3) chelating metal ions to trap intermediate dicarbonyl compounds in the formation of AGES, 4) blocking AGE‐RAGE interaction (Wu et al., 2011; Lin et al., 2016; Yeh et al., 2017; Anwar et al., 2021). Mechanisms of action that delay or prevent the glycation process may be a pathway that retard the development of T2DM.…”

Section: The Alternative In the Prevention Of T2dm: Functional Foods And Bioactive Compoundsmentioning

confidence: 99%

Cabbage (Brassica oleracea var. capitata): A food with functional properties aimed to type 2 diabetes prevention and management

Narvaez

Campos

2021

Journal of Food Science

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Type 2 diabetes mellitus (T2DM) is increasing the prevalence worldwide at an alarming rate, becoming a serious public health problem that mainly affects developing countries. Functional food research is currently of great interest because it contributes to developing nutritional therapy strategies for T2DM prevention and treatment. Bioactive compounds identified in some plant foods contribute to human health by mechanisms of action that exert biological effects on metabolic pathways involved in the development of T2DM. Hence, vegetables with high bioactive compounds content may be a source of functional value for the control of T2DM. Cabbages varieties (Brassica oleracea var. capitata) such as green (GCB), white (WCB), and red (RCB) are foods consumed (raw or cooked) and cultivated in different regions of the world. Scientific evidence shows that cabbage has multi-target effects on glucose homeostatic regulation due to its high content of bioactive compounds. It has also been shown to decrease damage to organs affected by T2DM complications, such as the liver and kidney. Additionally, it could contribute as a preventive by attenuating problems underlying the development of T2DM as oxidative stress and obesity. This review highlights the functional properties of cabbage varieties involved in glucose regulation and the main mechanisms of the action exerted by their bioactive compounds. In conclusion, cabbage is a valuable food that can be employed as part of nutritional therapy or functional ingredient aimed at the prevention and treatment of T2DM.

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A review on mechanism of inhibition of advanced glycation end products formation by plant derived polyphenolic compounds

Cited by 96 publications

References 117 publications

Serum Albumin in Health and Disease: Esterase, Antioxidant, Transporting and Signaling Properties

Serum Albumin in Health and Disease: Esterase, Antioxidant, Transporting and Signaling Properties

A Network Pharmacology Study on the Molecular Mechanism of Protocatechualdehyde in the Treatment of Diabetic Cataract

Cabbage (Brassica oleracea var. capitata): A food with functional properties aimed to type 2 diabetes prevention and management

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