A Review on Medicinal Properties of Saffron toward Major Diseases

Razak, Saiful Izwan Abd; Hamzah, Mohd Syahir Anwar; Yee, Foong Choi; Kadir, Mohammed Rafiq Abdul; Nayan, Nadirul Hasraf Mat

doi:10.1080/10496475.2016.1272522

Cited by 41 publications

(24 citation statements)

References 49 publications

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“…The immense properties of this spice marks it as a red Gold for any country capable of growing this evocative spice as its commercialization would fetch tangible profits, that would in turn help in uplifting the socio-economic conditions of people and would pave a way to leverage the economy. There are numerous properties attributed to this delicate golden crop ranged including therapeutic medicinal benefits and capacity to be an agent for pharmaceutical industry ( Ferrence and Bendersky, 2004 , Hosseini et al, 2018 , Mir et al, 2020 , Nemati et al, 2014 , Razak et al, 2017 ). However, there are multitude of challenges which the current saffron industry is facing and to overcome these challenges to an extent, biotechnological interventions could play a crucial role to ameliorate this precious crop at the molecular level such as disease, abiotic stress resistant cultivars or cultivars with superior chemical profiling etc.…”

Section: Discussionmentioning

confidence: 99%

Deciphering genetic diversity analysis of saffron (Crocus sativus L.) using RAPD and ISSR markers

Mir

Mansoor

Sugapriya

et al. 2021

Saudi Journal of Biological Sciences

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The existence of genetic diversity in Crocus sativus has globally remained a mystery till date. The study investigated PCR based DNA amplification profile of saffron using ISSR and RAPD based primers. A total of 38 amplicons were generated by ISSR primers in the range from 7 to 12 with an average of 9.50 bands per primer. 20 bands were found to be polymorphic and 18 were monomorphic with an average percentage of polymorphism as 52.48%. RAPD based amplification revealed a total 161 amplicons, 107 as polymorphic and 54 as monomorphic with an average percentage of polymorphism as 66.44%. Cumulative results of RAPD and ISSR demonstrated that Nei-Li’s similarity index ranged between 0.70 and 0.97. The results of AMOVA has revealed 9% of variance among populations and 91% of variance within populations, Φ PT was found as 0.089, which indicates existence of genetic differences though limited. In conclusion, the results indicate that saffron accessions are minimally genetically differentiated, which could be capitalized in future breeding programmes to ameliorate this precious crop.

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Section: Discussionmentioning

confidence: 99%

Deciphering genetic diversity analysis of saffron (Crocus sativus L.) using RAPD and ISSR markers

Mir

Mansoor

Sugapriya

et al. 2021

Saudi Journal of Biological Sciences

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“…Saffron, in addition to being used in foods as flavoring and coloring, has been used as a natural preservative and for its possible pharmacological properties [6,36,76,77]. There are numerous scientific studies in the last 10 years that highlight the biomedical and pharmacological properties of saffron or some of its metabolites in the prevention and development of various chronic diseases [8,76,77,78,79,80].…”

Section: Bioactivity Of Crocus Sativus L Compoundsmentioning

confidence: 99%

Bioactivity and Bioavailability of the Major Metabolites of Crocus sativus L. Flower

et al. 2019

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Crocus sativus L. has been cultivated throughout history to obtain its flowers, whose dried stigmas give rise to the spice known as saffron. Crocetin esters, picrocrocin, and safranal are the main metabolites of this spice, which possess a great bioactivity, although the mechanisms of action and its bioavailability are still to be solved. The rest of the flower is composed by style, tepals, and stamens that have other compounds, such as kaempferol and delphinidin, which have an important antioxidant capacity, and these can be applied in foods, phytopharmaceuticals, and cosmetics. The aim of this work was to provide an updated and critical review of the research on the main compounds of Crocus sativus L. flower, including the adequate analytical methods for their identification and quantification, with a focus on their bioactivity and bioavailability.

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“…However, the medicinal and pharmaceutical use of saffron disappeared with the advent of synthetic chemistry-derived drugs. More recently, however, scientific interest in revisiting saffron’s known bioactivity has been growing [ 11 , 12 ]. The bioactive properties observed in recent scientific publications are attributed to the main components, mentioned above, but also to the synergistic activity of all the compounds present in the spice.…”

Section: Chemical Composition Of Saffronmentioning

confidence: 99%

Saffron: An Old Medicinal Plant and a Potential Novel Functional Food

et al. 2017

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The spice saffron is made from the dried stigmas of the plant Crocus sativus L. The main use of saffron is in cooking, due to its ability to impart colour, flavour and aroma to foods and beverages. However, from time immemorial it has also been considered a medicinal plant because it possesses therapeutic properties, as illustrated in paintings found on the island of Santorini, dated 1627 BC. It is included in Catalogues of Medicinal Plants and in the European Pharmacopoeias, being part of a great number of compounded formulas from the 16th to the 20th centuries. The medicinal and pharmaceutical uses of this plant largely disappeared with the advent of synthetic chemistry-produced drugs. However, in recent years there has been growing interest in demonstrating saffron’s already known bioactivity, which is attributed to the main components—crocetin and its glycosidic esters, called crocins, and safranal—and to the synergy between the compounds present in the spice. The objective of this work was to provide an updated and critical review of the research on the therapeutic properties of saffron, including activity on the nervous and cardiovascular systems, in the liver, its antidepressant, anxiolytic and antineoplastic properties, as well as its potential use as a functional food or nutraceutical.

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A Review on Medicinal Properties of Saffron toward Major Diseases

Cited by 41 publications

References 49 publications

Deciphering genetic diversity analysis of saffron (Crocus sativus L.) using RAPD and ISSR markers

Deciphering genetic diversity analysis of saffron (Crocus sativus L.) using RAPD and ISSR markers

Bioactivity and Bioavailability of the Major Metabolites of Crocus sativus L. Flower

Saffron: An Old Medicinal Plant and a Potential Novel Functional Food

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