A review on the neural bases of episodic odor memory: from laboratory-based to autobiographical approaches

Saive, Anne-Lise; Royet, Jean-Pierre; Plailly, Jane

doi:10.3389/fnbeh.2014.00240

Cited by 84 publications

(73 citation statements)

References 135 publications

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“…This finding is consistent with the known link between olfaction and the hippocampal memory system [12, 26], and concurrent age-related decline of both olfactory processing and hippocampal-related memory functioning [6–9]. Moreover, FC between the ON and the hippocampus was significantly stronger than FC between the TN and the hippocampus, even after controlling for age effects.…”

Section: Discussionsupporting

confidence: 87%

Age-related resting-state functional connectivity in the olfactory and trigeminal networks

Karunanayaka¹,

Tobia

Yang

2017

NeuroReport

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Brain networks for intranasal chemosensation have been shown to be intrinsically organized in humans [1]. However, little is known about how changes in the intrinsic functional connectivity (FC) in chemosensory networks are related to aging. We, therefore, investigated the impact of age on resting state functional connectivity in the olfactory and trigeminal networks (ON and TN) by combining two freely available resting state fMRI data sets (obtained from the NITRC.org; Atlanta and New York) with data collected in our lab to generate a large sample size (N=103; 51 females) spanning the age range of 20–61 years. Seed regions were defined using MNI coordinates that anchor olfactory and trigeminal networks in activation studies and meta-analyses. The olfactory network (ON) included the piriform cortex and oribtofrontal cortex. The trigeminal network (TN) included the anterior insula and cingulate cortex. Scanner site, sex, and age were used as covariates in group level analyses. The FC between the ON and parahippocampal gyrus was negatively correlated with age. The FC between the TN and parahippocampal gyrus, however, was positively correlated. Similarly, age was positively correlated with the ON FC to the ventral striatum, and the TN FC to the default mode network (DMN). These results reflect divergent age-related alterations of the intrinsic FC of the human chemosensory system.

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Section: Discussionsupporting

confidence: 87%

Age-related resting-state functional connectivity in the olfactory and trigeminal networks

Karunanayaka¹,

Tobia

Yang

2017

NeuroReport

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“…It is well known that the hippocampus is essential for learning and memory retrieval in humans (Miller and D'Esposito, 2012). Specifically, in olfaction, the hippocampus plays a role in creation of mental images of odors, memory, and the formation of complex sensory associations Saive et al, 2014). However, as previously noted by Royet and colleagues (2013), olfactory experts showed lesser involvement of the hippocampus and other key regions involved in olfaction and odor-specific memory or associations with a greater level of expertise.…”

Section: Effective Connectivity Differences Between Sommeliers and Comentioning

confidence: 40%

Olfactory Network Differences in Master Sommeliers: Connectivity Analysis Using Granger Causality and Graph Theoretical Approach

et al. 2017

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Previous studies investigating the differences in olfactory processing and judgments between trained sommeliers and controls have shown increased activations in brain regions involving higher level cognitive processes in sommeliers. However, there is little information about the influence of expertise on causal connectivity and topological properties of the connectivity networks between these regions. Therefore, the current study focuses on addressing these questions in a functional magnetic resonance imaging (fMRI) study of olfactory perception in Master Sommeliers. fMRI data were acquired from Master Sommeliers and control participants during different olfactory and nonolfactory tasks. Mean time series were extracted from 90 different regions of interest (ROIs; based on Automated Anatomical Labeling atlas). The underlying neuronal variables were extracted using blind hemodynamic deconvolution and then input into a dynamic multivariate autoregressive model to obtain connectivity between every pair of ROIs as a function of time. These connectivity values were then statistically compared to obtain paths that were significantly different between the two groups. The obtained connectivity matrices were further studied using graph theoretical methods. In sommeliers, significantly greater connectivity was observed in connections involving the precuneus, caudate, putamen, and several frontal and temporal regions. The controls showed increased connectivity from the left hippocampus to the frontal regions. Furthermore, the sommeliers exhibited significantly higher small-world topology than the controls. These findings are significant, given that learning about neuroplasticity in adulthood in these regions may then have added clinical importance in diseases such as Alzheimer's and Parkinson's where early neurodegeneration is isolated to regions important in smell.

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“…In contrast, the primary olfactory network (ON) is linked to conscious memory processing [10] and shows a high correlation between olfactory sensory impairment and age-related memory decline [11], which is a risk factor for developing dementia [12,13]. The core ON includes the orbitofrontal cortex (OFC) and the piriform region in the anterior temporal cortex, and extends into the amygdala [14] and episodic memory systems [15,16].…”

Section: Introductionmentioning

confidence: 99%

Intrinsic intranasal chemosensory brain networks shown by resting-state functional MRI

2016

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The human brain is organized into functional networks for sensory-motor and cognitive processing. Intrinsic networks are detectable in the absence of stimulation or task demands, whereas extrinsic networks are detectable when stimulated by sensory or cognitive demands. Intranasal chemosensory processing relies on two dissociable networks for processing incoming trigeminal and olfactory stimulation, but it is not known whether these networks are intrinsically organized. The aim of this study was to identify whether brain networks for intranasal chemosensory processing are detectable in functional connectivity resting-state functional MRI (fMRI). Sixteen healthy adults participated in a 5-min resting-state fMRI study. Functional connectivity seeds were defined from coordinates that anchor olfactory (i.e. bilateral piriform and orbitofrontal cortex) and trigeminal (bilateral anterior insula and cingulate cortex) networks in published task activation studies, and the resulting networks were thresholded at P less than 0.001. The olfactory network showed extended functional connectivity to the thalamus, medial prefrontal cortex, caudate, nucleus accumbens, parahippocampal gyrus, and hippocampus. The trigeminal network showed extended functional connectivity to the precuneus, thalamus, caudate, brainstem, and cerebellum. Both networks overlapped in the thalamus, caudate, medial prefrontal cortex, and insula. These results show that brain networks for intranasal chemosensory processing are intrinsically organized, not just extrinsically instantiated in response to task demands, and resemble networks for processing olfactory and trigeminal stimulation. As such, it may be possible to study the functional organization and dynamics of the olfactory network in resting-state fMRI as well as its implications for aging and disease.

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A review on the neural bases of episodic odor memory: from laboratory-based to autobiographical approaches

Cited by 84 publications

References 135 publications

Age-related resting-state functional connectivity in the olfactory and trigeminal networks

Age-related resting-state functional connectivity in the olfactory and trigeminal networks

Olfactory Network Differences in Master Sommeliers: Connectivity Analysis Using Granger Causality and Graph Theoretical Approach

Intrinsic intranasal chemosensory brain networks shown by resting-state functional MRI

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