A review on wound dressings: Antimicrobial agents, biomaterials, fabrication techniques, and stimuli-responsive drug release

Naseri, Emad; Ahmadi, Ali

doi:10.1016/j.eurpolymj.2022.111293

Cited by 63 publications

(33 citation statements)

References 316 publications

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“…Natural biopolymers deserve special attention, being studied with the aim of overcoming the disadvantages of synthetic materials. The most well-known natural biopolymers used for wound dressing are collagen, gelatin, silk sericin, alginate, chitin, and chitosan, with collagen being by far the most studied [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

Bacterial Cellulose—Carboxymethylcellulose Composite Loaded with Turmeric Extract for Antimicrobial Wound Dressing Applications

Isopencu

Deleanu

Busuioc

et al. 2023

IJMS

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Bacterial cellulose (BC) is a biopolymer whose properties have been intensively studied, especially for biomedical applications. Since BC has no antimicrobial activity, it is necessary to use bioactive substances for developing wound healing applications. Another drawback of BC is the loss if its water retention capacity after dehydration. In order to overcome these problems, carboxymethyl cellulose (CMC) and turmeric extract (TE) were selected for the preparation of BC composites. Citric acid (CA) was used as the crosslinking agent. These composites were tested as potential antimicrobial wound dressing materials. TE-loaded BC–CMC composites were characterized in terms of their morphology, crystallinity, and thermal behavior. Swelling tests and curcumin-release kinetic analysis were also performed. All the composites tested had high swelling degrees, which is an advantage for the exudate adsorption from chronic wounds. The antibacterial potential of such composites was tested against Escherichia coli (E. coli), Staphylococcus aureus (S. aureus), and Candida albicans (C. albicans). The in vitro cytotoxicity toward L929 fibroblast cells was studied as well. The obtained results allow us to recommend these composites as good candidates for wound dressing applications.

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Section: Introductionmentioning

confidence: 99%

Bacterial Cellulose—Carboxymethylcellulose Composite Loaded with Turmeric Extract for Antimicrobial Wound Dressing Applications

Isopencu

Deleanu

Busuioc

et al. 2023

IJMS

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“…[ 1‐3 ] The usage of antibiotics and traditional dressings such as gauzes and bandages is the widespread clinical management. [ 4 ] However, the long‐term use of antibiotics has brought a series of adverse effects including drug‐resistance and organ damage. [ 5‐7 ] The remove or change of gauzes or bandages could also result in the second hurt to the wounds in clinical applications.…”

Section: Background and Originality Contentmentioning

confidence: 99%

Multi‐Functional Supramolecular‐Polymeric Hybrid Hydrogel for Promoting Cutaneous Wound Repair^†

Wei,

Jia,

Wang

et al. 2023

Chin. J. Chem.

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Comprehensive SummarySupramolecular‐polymeric hybrid hydrogels combining advantages of the assembled supramolecular networks and polymeric networks have attracted considerable attention recently. However, they are rarely used as multi‐functional wound dressing materials. In this work, we report a supramolecular‐polymeric hybrid hydrogel consisting of a co‐assembled DBS‐COOH/Naproxen network (DBS/NAP) and a polymeric gelatin (G)/quaternary ammonium group (Q) and phenylboronic acid groups (PBA)‐grafted chitosan (QCS‐PBA) network (G/QCS) for accelerating skin wound healing. The polymeric networks could obviously enhance the mechanical properties of the drug‐derived supramolecular networks. Q groups endowed the hydrogel with enhanced antibacterial properties. Borate ester crosslinking between PBA groups and diol groups in DBS‐COOH could effectively scavenge reactive radicals. The hybrid hydrogel exhibited tunable mechanical and adhesive properties due to the temperature‐responsive gelatin networks. NAP could gradually release from hybrid hydrogel networks thus continuously relieving inflammation. Finally, the biocompatible, adhesive, antibacterial and antioxidant hybrid G/QCS‐DBS/NAP gel could promote the in vivo healing stages in a full‐thickness wounds with increased collagen deposition, upregulated CD31 expression and down‐regulated TNF‐α expression. Overall, this multi‐functional supramolecular‐polymeric hybrid hydrogel exhibited great potential for treating skin defects as promising wound dressing materials.

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“…A wound is an injury on the outside body part tissue that disturbs physical function. 1,2 Approximately 1% of the world's population is believed to be affected by wounds. 3 Meanwhile, the prevalence of wounds in Indonesia based on the proportion of injuries is 20%.…”

Section: Introductionmentioning

confidence: 99%

Wound healing activity and flavonoid contents of purslane (Portulaca grandiflora) of various varieties

et al. 2023

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A review on wound dressings: Antimicrobial agents, biomaterials, fabrication techniques, and stimuli-responsive drug release

Cited by 63 publications

References 316 publications

Bacterial Cellulose—Carboxymethylcellulose Composite Loaded with Turmeric Extract for Antimicrobial Wound Dressing Applications

Bacterial Cellulose—Carboxymethylcellulose Composite Loaded with Turmeric Extract for Antimicrobial Wound Dressing Applications

Multi‐Functional Supramolecular‐Polymeric Hybrid Hydrogel for Promoting Cutaneous Wound Repair^†

Wound healing activity and flavonoid contents of purslane (Portulaca grandiflora) of various varieties

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A review on wound dressings: Antimicrobial agents, biomaterials, fabrication techniques, and stimuli-responsive drug release

Cited by 63 publications

References 316 publications

Bacterial Cellulose—Carboxymethylcellulose Composite Loaded with Turmeric Extract for Antimicrobial Wound Dressing Applications

Bacterial Cellulose—Carboxymethylcellulose Composite Loaded with Turmeric Extract for Antimicrobial Wound Dressing Applications

Multi‐Functional Supramolecular‐Polymeric Hybrid Hydrogel for Promoting Cutaneous Wound Repair†

Wound healing activity and flavonoid contents of purslane (Portulaca grandiflora) of various varieties

Contact Info

Product

Resources

About

Multi‐Functional Supramolecular‐Polymeric Hybrid Hydrogel for Promoting Cutaneous Wound Repair^†